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Doctor insights on: Benadryl Maximum Strength Medication

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Can I take two extra strength Benadryl (diphenhydramine) night time?

Can I take two extra strength Benadryl (diphenhydramine) night time?

50 mg total: You can take a total of 50 mg up to every 4 hours. I've never heard of extra strength Benadryl (diphenhydramine) (they do make a 50 mg tablet, but I've always seen it behind the counter at a pharmacy). All the over-the-counter strengths I've ever seen are 25 mg, so you can take 2 of those. ...Read more

Dr. John Chiu
1,049 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Is it okay to mix Benadryl (diphenhydramine) with my other medications?

Is it okay to mix Benadryl (diphenhydramine) with my other medications?

Avoid these: Older antihistamines like Benadryl (diphenhydramine) interact with many drugs. Don't mix it with alcohol, sleeping pills, sedatives, antidepressants, potassium supplements, sodium or potassium phosphate, antipsychotics, MAO inhibitors, symlin (pramlintide), sodium oxybate, Precedex (dexmedetomidine) & abilify (aripiprazole). Loratidine and fexofenadine are as effective & much safer. Discuss this with your doctor. ...Read more

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I am having a reaction to insect bites. I have Extra Strength Benadryl (diphenhydramine) Nighttime, 1 50mg pill isn't working can I take 2?

I am having a reaction to insect bites. I have Extra Strength Benadryl (diphenhydramine) Nighttime, 1 50mg pill isn't working can I take 2?

Benadryl (diphenhydramine): 50mg is the recommended dose but adults can take 400mg in 24 hours. Take 50mg 30 minutes before bedtime and if not effective by 30 minutes repeat the dose. If this is making you drowsy the following day you know it is too much. Your size and weight may have a lot to do with your dose. All the best. ...Read more

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Will Benadryl (diphenhydramine) regular strength make my asthma worse?

Will Benadryl (diphenhydramine) regular strength make my asthma worse?

Use with caution: The antihistamine products like benedryl will thicken your mucous secretions which can be a problem for those on the margins with asthma. Asthma patients tend to have problems with excess secretions already & thickening them lakes it harder for them to be cleared from the airways. Benedryl can often be used during periods of good control, but I avoid it during flares. ...Read more

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Can you take Benadryl (diphenhydramine) if you are taking other types of medication for allergies?

Can you take Benadryl (diphenhydramine) if you are taking other types of medication for allergies?

Yes: The limiting factor as to how much antihistamine one can take is generally what the side-effects are. If it makes you too sleepy when combined with other anti-histamines then you should be careful about combining them. ...Read more

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Can extra strength Benadryl (diphenhydramine) gel cause drowsiness?

Can extra strength Benadryl (diphenhydramine) gel cause drowsiness?

Very unlikely: Unless you are covering a large area for an extended period of time or areas with breaks in the skin, it's highly unlikely this would be absorbed systemically to cause drowsiness. ...Read more

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Can you take corricidin maximum strength flu and Benadryl (diphenhydramine) together?

Can you take corricidin maximum strength flu and Benadryl (diphenhydramine) together?

NO: Using chlorpheniramine (the antihistamine in corricidin) together with Diphenhydramine (benadryl (may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, rapid heart beats, confusion, and memory problems. They are both similar acting drugs. Do not take together. ...Read more

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Are there any immediate acting allergy medications I can take other than Benadryl (diphenhydramine)?

Are there any immediate acting allergy medications I can take other than Benadryl (diphenhydramine)?

Several: OTC second generation antihistamines as cetirizine and loratadine, but read the labels and instructions carefully ...Read more

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Might I use Benadryl (diphenhydramine) itch cream (extra strength) with Benadryl (diphenhydramine) allergy pills?

Might I use Benadryl (diphenhydramine) itch cream (extra strength) with Benadryl (diphenhydramine) allergy pills?

Benadryl (diphenhydramine): Not sure what you are treating. The cream works best to relieve itchy insect bites. The pill is for more systemic allergies. You can use them together but I don't see what for. ...Read more

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If Benadryl's plasma clearance is about 9 hours x 5, how long would it remain active to affect the brain and interact with other medications?

If Benadryl's plasma clearance is about 9 hours x 5, how long would it remain active to affect the brain and interact with other medications?

Less than 12 hrs: It may take a long time for a drug to completely clear from the body, the biochemical effect occurs only with a certain blood level. I have yet seen anyone getting drowsy from Benadryl (diphenhydramine) for more than 12 hours. It is the drug level that matters. ...Read more

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I have asthma, allergies and pnd. I believe Benadryl (diphenhydramine) will curb my pnd, yet may harm asthma. Should I use it here and there at regular strength? Thank

Maybe maybe not: Often asthmatics do use antihistamines in cinjunctinwith their routine asthma meds. Discuss using a non-sedating antihistamine like Claritin with your phsyician. Have you tried nasal saline which does not affect your asthma and may reduce your pnd. ...Read more

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Can my baby 4 month old take allergy medication as Benadryl (diphenhydramine) or claritin?

Can my baby 4 month old take allergy medication as Benadryl (diphenhydramine) or claritin?

Not likely: At 4 months you should not be giving your child allergy meds. Take him to the pediatrician and see what is going on. ...Read more

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Do anticholinergic medications like Benadryl (diphenhydramine) have a link with mild cognitive impairment?

Do anticholinergic medications like Benadryl (diphenhydramine) have a link with mild cognitive impairment?

No: Unlikely; Benadryl (diphenhydramine) has drowsy effects, but clears out after few hours. Interestingly can cause paradoxical stimulation as a side effect. A chronic mild cognitive impairment could be something else. ...Read more

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Can the any of these medications be causing high blood pressure? Benadryl? Phenagran? And or reglan (metoclopramide)?

Can the any of these medications be causing high blood pressure? Benadryl? Phenagran? And or reglan (metoclopramide)?

All could be: If you look at the possible side effect profile for each of the drugs you mentioned, high blood pressure is listed as a possible side effect for each one. Side effect profiles for drugs are very patient dependent and very hard to predict. Sometimes starting and stopping medications in an orderly fashion can determine if one is causing the undesired side effect. Talk with your doc. ...Read more

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I've been trying to get pregnant and I am currently taking Zantac (acid reflux) and Benadryl. Could these medications keep me from conceiving? Thanks!

I've been trying to get pregnant and I am currently taking Zantac (acid reflux) and Benadryl. Could these medications keep me from conceiving? Thanks!

Possibly: Ranitidine has not been known to cause any problems with fertility or pregnancy, however diphenhydramine/Benadryl and other antihistamines theoretically can affect the implantation of the egg in the womb by decreasing bloodflow to the uterus. It is still debatable, (and there aren't any good studies on the subject), but it might be good to stop taking benadryl unless you REALLY need it. ...Read more

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I broke out with red like sunburn rash today all over body, took 50mg benadryl (diphenhydramine) and doesn't seem to help. Two days ago I was in bed all day because every joint in my body hurt and had no energy or strength... Not sure if it's related.

I broke out with red like sunburn rash today all over body, took 50mg benadryl (diphenhydramine) and doesn't seem to help. Two days ago I was in bed all day because every joint in my body hurt and had no energy or strength... Not sure if it's related.

Viral Illness: If your rash is red, raised, and itchy you could be suffering from acute hives (urticaria). Hives is a common manifestation during are shortly after a viral infection which it sounds like you are suffering from. Try treating with OTC nonsedating antihistamine like Zyrtec (cetirizine) 1-2 per day and symptomatic management (increased fluids, rest). If rash not responding see doctor to have evaluated. ...Read more

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I have red patches all over my body they itch. I went to the hospital and the gave me benadryl, (diphenhydramine) prednisone, &cimetidine these medications did nothing!?

I have red patches all over my body they itch. I went to the hospital and the gave me benadryl, (diphenhydramine) prednisone, &cimetidine these medications did nothing!?

Foolish: ER people treat heart attacks, accidents, emergencies. That's why we call it the emergency room. They are poor at treating "red patches all over". What did they call it? Stop this foolishness and see a dermatologist. When you call, indicate if it is urgent. Is your water safe yet? Do not take Benadryl (diphenhydramine) except bedtime. It is a sleeping pill. Cimetidine is for acid stomach, not for skin. You need a p ...Read more

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Can you take 5 mg of Vicodin and 25 mg of Benadryl together? I weigh 113 pounds and I'm a female. I have an ovarian cyst and I hardly ever take pain medications so I'm a little afraid and my allergies are killing me.

Can you take 5 mg of Vicodin and 25 mg of Benadryl together? I weigh 113 pounds and I'm a female. I have an ovarian cyst and I hardly ever take pain medications so I'm a little afraid and my allergies are killing me.

Nasal steroid?: Whether you can take these medications depend greatly on their adverse effects. Both Benadryl and Vicodin have sedating effect and Vicodin may cause abdominal upset for some people. However if the pain is bad, you may have little choice. If you are referring to nasal congestion, a nasal steroid will likely work better than an antihistamine. ...Read more

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Now off psych medications, like geodon, (ziprasidone) klonopin, ativan, trazodone, that put me to sleep. Am now using Benadryl evernight4 sleep no relaxation or wood

Now off psych medications, like geodon, (ziprasidone) klonopin, ativan, trazodone, that put me to sleep. Am now using Benadryl evernight4 sleep no relaxation or wood

Sleep: Since you have tried many medications for sleep it may be useful to change your lifestyle if you have not already. Daily exercise before 3pm, no caffeine after 3pm, no alcohol in the evening. If these methods do not work consult with a clinical psychologist who can help uncover the difficulties preventing sleep and how to develop better coping skills. My best. ...Read more

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What allergy medication is safe to take if have a history of kidney stones? Allegra, Zyrtec, Benadryl, (diphenhydramine) Claritin?

What allergy medication is safe to take if have a history of kidney stones? Allegra, Zyrtec, Benadryl, (diphenhydramine) Claritin?

All of them: Is unlikely any of these would have an adverse event on your kidney stones. Your physician can clearly help you with this decision ...Read more

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Can some drug you with benadryl (diphenhydramine)?

Can some drug you with benadryl (diphenhydramine)?

Yes: One can be drugged with anything. Benadryl (diphenhydramine) can cause drowsiness, dizziness, confusion, nausea, urinary retention and more if given high doses or to susceptible individuals. ...Read more

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What type of drug is Benadryl (diphenhydramine) and what are its uses?

Benadryl (diphenhydramine): It is a first generation antihistamine. Very powerful but has side effects that many 2nd generation otc antihistamines do not have. Among it uses are for allergies and in otc sleep aides. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more