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Doctor insights on: Benadryl Dosage Insomnia

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I took 75 mg of benadryl (diphenhydramine). I usually take 50 mg but I wanted to up the dose for my insomnia. Would anything bad happen?

I took 75 mg of benadryl (diphenhydramine). I usually take 50 mg but I wanted to up the dose for my insomnia. Would anything bad happen?

Bad: Benadryl (diphenhydramine) can make you sleepy, but it can have after effects. Studies show that using too much of it can lessen your responses similar to drinking alcohol. It is found in many over the counter sleep medications but I do not believe that most doctors would recommened them. Would check with your doctor. ...Read more

Dr. Heidi Fowler
1,704 Doctors shared insights

Insomnia (Definition)

A sleep disorder in which you cannot fall or stay asleep. It usually accompanies another sleep, medical, or psychiatric disorder, and can lead to memory impairment, mood changes, and increased risk of ...Read more


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What is the highest legal prescription dose of diphenahydramine? I have insomnia, and when I didn't have money for my prescription flurazepam 30 mg, I took benadryl. Reading somewhere that 200 mg was the max prescription dose, I've been taking it for mont

What is the highest legal prescription dose of diphenahydramine? I have insomnia, and when I didn't have money for my prescription flurazepam 30 mg, I took benadryl. Reading somewhere that 200 mg was the max prescription dose, I've been taking it for mont

There: There is no "legal" dose of any medication. Recommended maximum doses are listed in plain view on medicine containers. Exceeding those recommended doses significant increases the chances of experiencing an adverse side effects which could include death. You need to be discussing your medication use with you physician as exceeding recommended does or combining medications can have unintended consequences even in the healthiest individuals. ...Read more

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My dr is allowing me to stop geodon (ziprasidone). I reduced dosage and cannot sleep at all. This happened b4. Benadryl doesn't help. How do I sleep. Will it return?

My dr is allowing me to stop geodon (ziprasidone). I reduced dosage and cannot sleep at all. This happened b4. Benadryl doesn't help. How do I sleep. Will it return?

Call doctor: You need to contact your doctor regarding prescribing something to help you sleep during the transition phase or try tapering off the Geodon (ziprasidone) dose. ...Read more

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What to do? I am sleepless and frustrated. I am getting so frustrated. I was prescribed Benadryl for my insomnia and it worked.......For 2 days. Now, I am always awake. The last couple nights I have gone to bed at 1030. Gotten up at 1257am, gone to bed a

What to do? I am sleepless and frustrated. I am getting so frustrated. I was prescribed Benadryl for my insomnia and it worked.......For 2 days. Now, I am always awake. The last couple nights I have gone to bed at 1030. Gotten up at 1257am, gone to bed a

You: You need an evaluation by a sleep specialist. During the evaluation you lifestyle, habits, medication and medical history will be reviewed to determine the source of your insomnia. The insomnia may or may not be related to your pregnancy, but one this is for sure, if you do not take care of yourself then your baby will suffer. Have you discussed this with your OB physician? If not that is the place to start. ...Read more

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Is it okay to mix ambien and benadyrl to treat insomnia? I took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didn't work, are there side effects?

Is it okay to mix ambien and benadyrl to treat insomnia? I took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didn't work, are there side effects?

No don't mix drugs: Please don't mix ambien with benadryl (diphenhydramine). I would first suggest you speak with your doctor who prescribed you ambien and him/her that you are still experiencing insomnia. Mixing prescription medication with drugs like benadryl (diphenhydramine) can be dangerous. Perhaps you should improve your sleep hygiene first. Sleep same time every night, bed is used only for sleep, cool dark room, no distractions (TV) etc. ...Read more

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Is Benadryl (diphenhydramine) or simply sleep good for insomnia?

Is Benadryl (diphenhydramine) or simply sleep good for insomnia?

Temporarily: Taking otc meds and even prescription pills are ok for a short term basis. Insomnia is often a multifaceted issue that needs proper evaluation and treatment. Often proper sleep hygiene is enough to correct the problem without the need for medications. As with any sleep aid, physical dependence is possible so avoid regular use. It is best to consult with a sleep specialist. ...Read more

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I took 10mg Valium 4 hrs ago. A Benadryl (diphenhydramine) about 30 min ago for allergy. Can I still smoke marajuana for my insomnia?

I took 10mg Valium 4 hrs ago. A Benadryl (diphenhydramine) about 30 min ago for allergy. Can I still smoke marajuana for my insomnia?

Unpredictable mix: I'm going to sound like an old dad, but I wouldn't recommend that at all. You're putting a lot of things in your body that, when combined, have an unpredictable outcome. Talk to your doctor about what's going on. Some people actually get more awake after taking benadryl (diphenhydramine). ...Read more

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Severe insomnia. Have tried everything. Have taken two benadryl and 2 Ambien so far. Still can't sleep. Valerian root and melatonin don't work.

Severe insomnia. Have tried everything. Have taken two benadryl and 2 Ambien so far. Still can't sleep. Valerian root and melatonin don't work.

Have you seen a: Sleep specialist? In the meantime - how is your sleep hygiene? Retire & rise same time each day. Bedroom should be dark & cool - used only for sex & sleep. Turn off tv. No naps. Exercise regularly but not in late evening. No caffeine for 6 hrs & no alcohol or tobacco w/i 2 hrs of sleep. Dinner should be moderate sized & finished at least 2 to 3 hours before sleep. Can try warm milk, chamomile ...Read more

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Can my wife take Benadryl (diphenhydramine) for insomnia if she is breast feeding?

Can my wife take Benadryl (diphenhydramine) for insomnia if she is breast feeding?

Alternative: First, its great that she is breastfeeding. Appreciate her a lot for that. She could take a couple of doses of Benadryl (diphenhydramine) without sig risk neg effect on baby (10% irritability, . ...Read more

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I have severe insomnia caused by lexapro. What can I take together to make me sleep: zzzquil, nyquil, benadryl, (diphenhydramine) melatonin, clonidine?

I have severe insomnia caused by lexapro. What can I take together to make me sleep: zzzquil, nyquil, benadryl, (diphenhydramine) melatonin, clonidine?

Call doctor: In my practice, with my patients, I have rarely seen anyone develop severe insomnia because of lexapro (escitalopram). They may have had insomnia previously, and it's more noticeable as the depression improves. In any event, if you are experiencing side effects from a medicine, call your doctor for an appointment to discuss this in person and in detail. ...Read more

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Is it safe to take one 25mg Benadryl (diphenhydramine) capsule solely as a sleep aid? Insomnia for a week, taking a toll on my physical and emotional well being.

Yes: One week should be okay. As long as the package inserts are followed. In the long term you'll benefit most from educating yourself about proper sleep hygiene as opposed to a quick fix with pills. ...Read more

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Was put on remeron 30 mg, 4 mg Valium, . 2 mg clonidine, 6 mg melatonin and 50 mg Benadryl (diphenhydramine) for chronic insomnia spaced apart by an hour. Is this a lot?

Was put on remeron 30 mg, 4 mg Valium, . 2 mg clonidine, 6 mg melatonin and 50 mg Benadryl (diphenhydramine) for chronic insomnia spaced apart by an hour. Is this a lot?

Yes: It is not a good idea to mix all these drugs together since no one really knows what the outcome of the interaction may be given some many variables. If you have had so much problem falling asleep, consider getting a sleep study which may reveal the cause. ...Read more

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Can psychiatric meds rewire the brain to create a neverending insomnia? I can only sleep using Benadryl (diphenhydramine) & am worried for my future. Everyones sleeping

Can psychiatric meds rewire the brain to create a neverending insomnia? I can only sleep using Benadryl (diphenhydramine) & am worried for my future. Everyones sleeping

Insomnia: Insomnia may be caused by multiple conditions. Disrupted sleeping cycle by changing sleeping and waking up hours (shift work sleeping disorder) or hyperactive states (bipolar, adhd, drug abuse) or depression may be common reasons for that problem. Anxiety and ptsd, breathing disorders like COPD or sleep apnea can contribute. Benadryl (diphenhydramine) is helpful and not addictive. Make a consultation now! ...Read more

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Can taking diphenhydramine for a long time cause insomnia or sleeplessness?

Can taking diphenhydramine for a long time cause insomnia or sleeplessness?

Antihistamines: Although Diphenhydramine can allow for sleep, it can lead to rebound insomnia if used for very long. I would encourage you to consider working with your sleep hygiene first. Retire & rise same time each day. Keep bedroom dark & cool & use only for sex & sleep. Turn off tv. No naps. Exercise regularly but not in late evening. No caffeine for 6 hrs & no alcohol or tobacco w/i 2 hrs of sleep. Keep >. ...Read more

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Is there a difference between Dimenhydrinate and Diphenhydramine? Which one would be better to take occasionally for insomnia?

Is there a difference between Dimenhydrinate and Diphenhydramine? Which one would be better to take occasionally for insomnia?

Both antihistamines: Both of these medications have drowsiness as a side effect. Dimenhydrinate also known as Dramamine works better for dizziness, nausea, motion sickness, or vertigo. Once in the body it GIFs converted to diphenhydramine so the effects may be similar except that The half-life of diphenhydramine (Benadryl) is shorter than the Dimenhydrinate. ...Read more

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I have a severe case of insomnia, how much Diphenhydramine is necessary for me to fall asleep ASAP? I'm 190lb

Try 50 mg: But there is no guarantee that any dose of Benadryl (diphenhydramine) would help since there are many causes for insomnia. If your problem is this bad, you need to check with your doctor who may refer you for a sleep study if the problem is chronic. ...Read more

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Is stopping diphenhydramine for sleep going to cause any rebound insomnia or other symptoms? If so how long to overcome rebound symptoms?

Is stopping diphenhydramine for sleep going to cause any rebound insomnia or other symptoms? If so how long to overcome rebound symptoms?

Dependance: I am not aware of any dependance related to this drug (antihistamine), but the symptome of insomnia probably needs to be addressed probably with some lifestyle changes and some physical activity during the day to make you feel more tired and desiring to sleep without medications. Hope this is somewhat helpful. ...Read more

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Which medication is more effective in treating insomnia, promethazine or diphenhydramine? Which one causes more sedative effect?

Which medication is more effective in treating insomnia, promethazine or diphenhydramine? Which one causes more sedative effect?

It depends: The best way to treat insomnia most of the time is with improved sleep hygiene - avoid late day naps or caffeine, only use your bed for sleeping, and ensure you have a proper diet and exercise. Sedation is a side effect of the medicines you mentioned, patients may feel more sedate from either one depending on many things. ...Read more

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If diphenhydramine is a sleeping pill and an antihistamine, then why is it safe to take daily for allergy but not when insomnia is the issue?

If diphenhydramine is a sleeping pill and an antihistamine, then why is it safe to take daily for allergy but not when insomnia is the issue?

Good question.: As long as you don't exceed the dose or frequency on the label - they are equally risky/safe. Perhaps the concern more with insomnia than allergy is that sleep is a combo of physical and behavioral causes while allergy is considered all physical. So, some may think you should 1st try good sleep habits/hygiene before pills. Also they may fear dependence more w/ insomnia. Sharp thinking! ...Read more

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Itchy red blotches started on arms. Spread to neck, head, body, and legs. Benadryl (diphenhydramine) did not help. Difficulty sleeping. Ideas to help or what could be?

Itchy red blotches started on arms. Spread to neck, head, body, and legs. Benadryl (diphenhydramine) did not help. Difficulty sleeping. Ideas to help or what could be?

? HIVES: Sounds like hives/urticaria, but tough to diagnose rashes over the computer. See derm or your PCP for diagnosis and proper treatment. Good luck. ...Read more

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I have severe insomnia with no sleep at all. Diphenhydramine+melatonin and ambien (zolpidem) both work for me, but both are giving me chest pain. What to do?

I have severe insomnia with no sleep at all. Diphenhydramine+melatonin and ambien (zolpidem) both work for me, but both are giving me chest pain. What to do?

See your doctor: There are many causes of insomnia. It is important to contact your doctor to get a proper assessment, appropriate testing and referral to specialists if needed. In some cases there may be multiple causes going on simultaneously. There are many over the counter and prescription medications used to help with sleep, but the most effective approach is to diagnose and treat underlying cause (s). Best. ...Read more

Dr. John Chiu
1,047 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more