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Doctor insights on: Bcr Abl1 Kinase Domain Mutation

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Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more

Mutation (Definition)

In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more


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In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?

In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not  please provide the corresponding treatment for the result?

CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck! Of note, this can also occur in ALL. ...Read more

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If a person had bcr-abl in low amount in blood. Do they have cml?

If a person had bcr-abl in low amount in blood. Do they have cml?

Maybe not: It depends on the test. With fish a few positive cells out of 200 can be expected based on overlapping signal and the way the test is done. If the technique was pcr very low level positives have been seen in people without cml. ...Read more

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Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more

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If a person had bcr-abl in low amount in blood. Do they have cml?

Maybe not: It depends on the test. With fish a few positive cells out of 200 can be expected based on overlapping signal and the way the test is done. If the technique was pcr very low level positives have been seen in people without cml. ...Read more

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Can chronic myelogenous leukemia (bcr/abl) have any effect on cellular metabolism?

Why this question???: Unless you are doing some research yourself, this question has zero relevance for your/anyone's treatment for cml. So let us keep life simple and straightforward and not complicate it for all of us who are trying to help patients in desperate need for quick and simple guidance! ...Read more

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In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?

CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck! Of note, this can also occur in ALL. ...Read more

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WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution

WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution

Demand an answer: You have chronic granulocytic leukemia or one of its close relatives and you should have been told. There's no "solution" in terms of an easy cure, but this is a manageable illness. You owe it to yourself both to get the full picture from your physicians, and read up on this family of illnesses and the treatment options -- medication versus (at your young age) possible curative transplant Rx. ...Read more

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What does a creatine kinase of 137 mean?

Ck: By itself a lab test has little meaning. Tests are ordered and interpreted in the context of the individual patient extrapolating from study data obtained from similar patients. If no such data is available, interpreting the study value is speculative. ...Read more