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Doctor insights on: Bcr Abl1 Kinase Domain Mutation

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Years of persistent unknown luekocytosis (15-25k)&thrombosis (465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Years of persistent unknown luekocytosis (15-25k)&thrombosis (465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more

Mutation (Definition)

In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more


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In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?

In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?

CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck!

Of note, this can also occur in ALL. ...Read more

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If a person had bcr-abl in low amount in blood. Do they have cml?

If a person had bcr-abl in low amount in blood. Do they have cml?

Maybe not: It depends on the test. With fish a few positive cells out of 200 can be expected based on overlapping signal and the way the test is done. If the technique was pcr very low level positives have been seen in people without cml. ...Read more

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Years of persistent unknown luekocytosis (15-25k)&thrombosis (465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more

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If a person had bcr-abl in low amount in blood. Do they have cml?

Maybe not: It depends on the test. With fish a few positive cells out of 200 can be expected based on overlapping signal and the way the test is done. If the technique was pcr very low level positives have been seen in people without cml. ...Read more

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Can chronic myelogenous leukemia (bcr/abl) have any effect on cellular metabolism?

Why this question???: Unless you are doing some research yourself, this question has zero relevance for your/anyone's treatment for cml. So let us keep life simple and straightforward and not complicate it for all of us who are trying to help patients in desperate need for quick and simple guidance! ...Read more

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In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?

CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck!

Of note, this can also occur in ALL. ...Read more

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WBC Count is high, BCR-ABL Translocation ratio is 56.31% in bone marrow test. What is the exact problem? Please provide the solution

WBC Count is high, BCR-ABL Translocation ratio is 56.31% in bone marrow test. What is the exact problem? Please provide the solution

Demand an answer: You have chronic granulocytic leukemia or one of its close relatives and you should have been told. There's no "solution" in terms of an easy cure, but this is a manageable illness. You owe it to yourself both to get the full picture from your physicians, and read up on this family of illnesses and the treatment options -- medication versus (at your young age) possible curative transplant Rx. ...Read more

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What does a creatine kinase of 137 mean?

Ck: By itself a lab test has little meaning. Tests are ordered and interpreted in the context of the individual patient extrapolating from study data obtained from similar patients. If no such data is available, interpreting the study value is speculative. ...Read more

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What is the definition or description of: creatine kinase?

What is the definition or description of: creatine kinase?

Enzyme in muscle: Creatine kinase is an enzyme found in muscles throughout the body. There are different subtypes of the enzyme, called isoforms, which predominate in different organs. For instance, the isoform in skeletal muscles is different from that which is most heavily found in the heart muscle.

A blood tests detects levels of this in the body, for example if one suspects muscle inflammation. ...Read more

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How to reduce creatine kinase in the blood?

How to reduce creatine kinase in the blood?

Hydrate: Rest and hydration can reduce cpk. It would be advisable to stop the offending drugs! ...Read more

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How to reduce creatine kinase in the blood?

How to reduce creatine kinase in the blood?

Depends on cause: Creatinine kinase is released from injured muscle of all kinds, skeletal, cardiac and smooth muscles, under varying circumstances. The issue would be to determine the cause of the elevation and treat the underlying pathology. ...Read more

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Why would need a serum creatine kinase measurement?

Why would need a serum creatine kinase measurement?

Muscel injury: Ck levels are elevated with muscle injury. All muscles, skeletal, cardiac and smooth muscles release ck on injury. Some drugs and alcohol can also damage muscle and cause high ck. ...Read more

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What does the creatine kinase blood test looking for?

What does the creatine kinase blood test looking for?

Muscle injury: Creatine kinase is present in all types of muscles: skeletal, heart and smooth muscles. Any injury to the muscles will raise the level of this enzyme. Some drugs, e.g., statin can also increase the level. The level cannot be too low. ...Read more

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What supplements would lower creatine kinase levels.?

What supplements would lower creatine kinase levels.?

None: No supplements will lower creatine kinase which signifies potential muscle breakdown when elevated. In past, we tested CK when we suspected a heart attack. Levels can also be elevated when muscles are damaged (rare condition = rhabdomyolysis). Check out http://labtestsonline. Org/understanding/analytes/ck/tab/test/ & http://www. Mayomedicallaboratories. Com/test-catalog/Clinical+and+Interpretive/8336 ...Read more

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Is there treatment for phosphorylase and kinase deficiency?

Is there treatment for phosphorylase and kinase deficiency?

Not really: This is one of the glycogen storage diseases. Avoiding fasting and keeping food intake even, steady and moderate may make things easier. ...Read more

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Should I stop Lipitor (atorvastatin) 10mg since creatine kinase level shot up > 300...I'm 60, male.?

Should I stop Lipitor (atorvastatin) 10mg since creatine kinase level shot up > 300...I'm 60, male.?

Yes: I assume your doctor gave you those results - did he/she have any recommendations? If you have any muscle pain, chest pain, shortness of breath or other worriesome symptoms go to the ER. ...Read more

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I've done blood test today and my Creatine Kinase level shown is 322 IU/L. What does that indicate? How can I reduce this CK level to normal range?

I've done blood test today and my Creatine Kinase level shown is 322 IU/L. What does that indicate? How can I reduce this CK level to normal range?

Muscle issue: Creatine Kinase is an enzyme in muscles and any issue affecting the muscles, including exercise, can raise CK levels. You need to address the cause of the elevation. You may consult this site and then discuss the matter with your doctor who ordered the test.
http://www. Mayomedicallaboratories. Com/test-catalog/Clinical+and+Interpretive/8336 ...Read more

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How long does it take for creatin kinase levels to go down?

How long does it take for creatin kinase levels to go down?

Depends on cause: CPK levels are elevated due to injury to the muscles, it gets elevated with myocardial injury during heart attack and injury to the sleletal muscles as well. So it depends how much damage to the muscles is and the cause of the damage and responce to treatment of the underlying condition
it can take from few days to several days. ...Read more

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What does high protein kinase mean?

What does high protein kinase mean?

Unclear question: There are many enzymes called kinases. You may wish to discuss the matter with your doctor with the actual results. ...Read more

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What are the symptoms of high creatine kinase?

What are the symptoms of high creatine kinase?

None: In my series of medical students, almost all the men and a majority of the women who were even moderately focused on physical fitness had creatine kinase levels above reference range. Right or wrong, the lab's reference range assumes the person does not exercise. ...Read more

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How to reduce my creatine kinase what can I eat?

Start over: How high? Why was it checked? But no it's generally not a dietary issue. ...Read more

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What does a creatine kinase level of 322 indicate?

What does a creatine kinase level of 322 indicate?

Muscle injury: Ck level of 322 is elevated but not too high. Elevated levels of ck indicate muscle injury, however strenous physical activity will raise ck levels, especially if activity is done prior to blood draw. Some medications and alcohol can casue ck elevation. ...Read more

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What could cause an elevated creatine kinase test?

What could cause an elevated creatine kinase test?

Muscle injury: Creatinine kinase is released from injured or dead muscle cells, be those skeletal, cardiac of smooth muscle cells. Renal failure is also associtated with modestly elevated levels. ...Read more

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Should I be worried about my creatine kinase level?

What is the level?: Elevated creatinine kinase level indicated muscle injury. If it is elevated, please consult your doctor to determine the cause and determination of the need for a treatment and the proper treatment. ...Read more

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My creatine kinase level is 465 what does that indicate?

My creatine kinase level is 465 what does that indicate?

CPK: Hi, Ck or CPK is found in striated muscle, heart tissue, and brain, damage to either can increase the level in blood, also thyroid imbalance could increase CK due to muscle damage, CK clearance from body decreases in kidney disease.
Your level is mildly elevated which could be 2/2 exercise, trauma to muscle, accident. ...Read more