Doctor insights on:
Bcr Abl1 Kinase Domain Mutation
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more
Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?
Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more
With bipolar ii, adhd, & c ptsd, what additional tests are beneficial? Ie: hormone, neurotransmitter , DNA mutation (mthfr, a1at ...) methylation etc.
Yes: I would definitely check mthfr and comt. Both these are involved in methylation. One is involved in neurotransmitter synthesis, and the other in breakdown. Therefore polymorphisms can impact mood, etc, and if so, vitamins and supplements can help the methylation cycle. I check mthfr in most of my patients. ...Read moreSee 4 more doctor answers
Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more
Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?
Asking what?: If your are requesting a diagnosis online, this is not the appropriate venue. Though the flow cytometry results are not totally normal, your results should be reviewed with the physician who ordered it. This format does not give us the ability to determine if your clinical presentation and lab results are consistent with a specific diagnosis. ...Read more
Yes: It is a factor XII issue which is encoded in your genome. ...Read more
LDH Isoenzymes lab test results:
LDH total- 153. LD1- 32, LD2-30, LD3, 20, LD4- 8, LD5- 10. Are these results normal? Is the LD1&LD2 ratio abnormal?
Historic test: Matthew, the LDH isoenzyme test is ancient history, almost never ordered nowadays. And your LDH is normal. The old 1-2 ratio is an antique screen for a heart attack, and it's neither sensitive nor specific. I know you're obsessing over the idea that you have lymphoma, and a few websites suggest this as a screening test -- but it's not. Focus on building a life for yourself. ...Read more
Probably: but most patients have many other reasons to have a high LDH ...Read more
Slightly elevated beta fraction from serum protein electrophoresis. Beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen. Immunofixation normal.
Chronic osteomylitis, bone marrow biopsy normal, jak-2 mutation negative, erythropoitin level normal, s.Ferritin level 5 but hb.17.8.What is its reason ?
Many possibilities: Your question is why your hemoglobin is at the top-of-normal (or maybe a tiny bit above) for a person of your age and gender. I'm much, much more concerned about your chronic osteomyelitis. I'd consider a right-to-left cardiac shunt, osler-weber-rendu lung shunt, sleep apnea, high-affinity hemoglobin, an obscure mutation. It's not dangerous in itself & could "just be you.". ...Read more
Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?
Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets
Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more
-incom. Rt. Bundle branch block
-cholesterol (total), serum by enzymatic method 208
-biochemistry lipid profile : LDL cholesterol, serum 133
Unlikely 2B related: Total and LDL cholesterol look ok, unless you have heart disease or multiple risk factors for heart disease, then LDL goal is <100. Inocmplete rbbb can be normal. Sometimes is just actually a "r s r-prime" pattern in certain electrocardiogram leads- many times a normal finding seen in healthy young military recruits. Incomplete rbbb can progress to a complete right bundle block. ...Read moreSee 1 more doctor answer
Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??
Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more
SPEP test: High Alapha1 .27 (.10-.20) High Alpha1% 3.6% (1.4-2.7%) High Gama 1.23 (.6-.1.2) Low Beta 5.9% (6-9%) and IFE tested positive. Cancer?
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, none of the information you provided suggests cancer. Ife was positive for what? For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. Get HPV vaccine. ...Read more