Doctor insights on:
Bcr Abl Rearrangement W Reflex
Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more
Is a simple coagulation lab test (PT/PTT INR & Fibrinogen) sufficient to diagnose Protein C,
&/or Factor V leidmen mutation disorders?
Normal C-RP, Sed Rate, CBC, CMP, Rheumatoid fac., C3/C4 Complement and Cyclic Citrul peptide. ANA was negative. Does this rule out any auto-immune?
Not necessarily: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Lab test do not equate to disease or the lack of it. It is good that all the test results are negative. It reduces your risk of an auto-immune disease to very very low, but does not exclude it 100%. ...Read more
Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?
Asking what?: If your are requesting a diagnosis online, this is not the appropriate venue. Though the flow cytometry results are not totally normal, your results should be reviewed with the physician who ordered it. This format does not give us the ability to determine if your clinical presentation and lab results are consistent with a specific diagnosis. ...Read more
Heterozygous for MTHFR, have high Protein C & Fact, VIII. Taking 3mg methylfolate for 3 mo, homocysteine normal . Reason to follow up w. hematologist?
No: Forgive my frankness. Most of us pathologists do not believe in this MTHFR screening being promoted by a lab to physicians worried about liability. A majority of folks test "abnormal" and are then offered questionable vitamin supplements. Reference ranges arbitrarily put several percent of healthies outside; high protein C and factor VIII are not worrisome especially if you feel well. ...Read more
Ds le cas du carence de Ca ds les cellules ces dernieres seront moins sensibles aux hormones thyroidiens malgre taux normal de t3, (liothyronine)t4.c'est vrai?
Monoclonal T cell beta gene rearrangement in blood /normal CBC / ANA / CMP / high Uric acid. Bouts of itching and hives. Significance?
?: Can still be chronic idiopathic urticaria, but other lab tests need to be performed as well: thyroid function tests, thyroid antibodies, complement levels, stools analysis, etc.. also other pieces of history need to be known, better see an allergist, check aaaai.org or acaai.org for an allergist in your area, meanwhile keep taking whatever antihistaminic on regulat basis, good luck ...Read more
Sev. Dev. Delay -array comparative genetic hybridization (acgh) results indicate no abnormalities- would full genetic sequencing be advised (knome)?
Not necessarily: Newer genetic tests provide incite into a variety of issues like autism & other developmental variations.Yet causation remains elusive in many cases.Sadly, an injury to the developing brain centers from an unrecognized event in an otherwise normal pregnancy is a likely cause for many.This occurs in at least half of cerebral palsy cases & dev.Delay could be produced in others, yet hard to prove. ...Read more
Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?
Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more
My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?
Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more
4/5 results- test neg scl70, double stranded dna, ssa, ssb, smith rmp sederate, esr&crp norm, electrolyte/white/red blood norm.Again + ANA 1:160 centromer. What additional test to exclude scleroderma/crest?
My 6 yo had appt w/ hematology. Results show elevated ldh, elevated retic and increased hgb F. Is this consistent with beta thalassemia trait?
I have positive ANA sm, ssa (ro), ssb (la) , ro52, jo-1, sci-70, ribosomal p antibodies what are the levels for each antibody that signify lupus ?
Level not important: If these antibodies are truly positive the degree of positivity is not that important. ...Read more
Can comprehensive chromosome screening (CCS) in IVF screen for (1) partial trisomy, (2) unbalanced translocation, and (3) balanced translocation? Does testing parental karyotyping before CCS help?
Test for Aneuploidy: Aneuploidy is the term used to describe any embryo with either too many or too few chromosomes. It is the cause of greater than 60% of miscarriages, as well as the most likely reason that patients do not get pregnant from an IVF cycle. The purpose of CCS is to analyze, select and transfer only embryos that do not have abnormalities in their number of chromosomes. A genetic consult is needed; ...Read more
What would b the cause of chronic high T cell counts, cd4, 5, 7, and 8. A T-cell beta gene rearrangement, elevated IGG, elevated LGL's, but normal CBC?
Reason for doing it: What was the reason you got this done. In all patients we don't do T cell count, Immunoglobulin level estimation etc. What were your symptoms. Based on your answerc an give a better explanation. In any patient we do CBC- complete blood count with differential count.Only in people with suspected immunodeficiencies/hematological problems-dyscrasias is the term we use, detailed Tcell,B cell ,Ig done ...Read more
Path. Report"the panel reveals no increase in cd3+cd8+ intraepithelial t-lymphocytes. Cd3 & cd20 dem. Lymphocytes w/ a reactive pat. Of dist." means ?
Lymphocytes: This is describing t and b lymphocytes, but without context one cannot interpret what the report means. ...Read more
Ihc right tonsil-fnhl grade 3a stage 1(bcl2, bcl6, cd20:+ve). Bone marrow ihc(bcl2&bcl6: -ve, cd10: focal +ve, reactive aggregates).Is it stage 4 or 1?
Epstein-barr tst rslts - what do they mean? Ref rng <0.91, VCA ab in rng, VCA ab IgG 4.46 out +, nucl ag (ebna)(igg) >5.00 +, cyto ab (igg) 3.91 +
Possible exposure: Igg positive antibodies which you have, indicate a past infection and not recent i.e. Active. Positive i gm antibodies usually indicate current infection. This means you may be have been exposed to mono in the past, the debate still goes on whether there's any correlation between this and chronic fatigue syndrome as many patients who have positive igg or igm do not have chronic fatigue symptoms. ...Read more
Not directly: Proteinase 3 ab is an antibody used in evaluating patients suspected of having wegener's granulomatosis (wg), a type of inflammation of the blood vessels (vasculitis). Wg is a rare autoimmune vasculitis that can affect the kidneys and the lungs, as well as other organs. Persons with wg may be at increased risk to develop cancer of the bladder, kidney, and skin as well as leukemia or lymphoma. ...Read more
Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?
No: Can't interpret random blood test results without context. Talk to the doctor that ordered the tests. Most medical tests (x-rays, blood tests, etc., ) are better at telling us what you don't have rather than diagnosing what (if anything) you do have wrong with you. ...Read more
Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?
Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more
Why this question???: Unless you are doing some research yourself, this question has zero relevance for your/anyone's treatment for cml. So let us keep life simple and straightforward and not complicate it for all of us who are trying to help patients in desperate need for quick and simple guidance! ...Read more
In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?
CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck! Of note, this can also occur in ALL. ...Read more
WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution
Demand an answer: You have chronic granulocytic leukemia or one of its close relatives and you should have been told. There's no "solution" in terms of an easy cure, but this is a manageable illness. You owe it to yourself both to get the full picture from your physicians, and read up on this family of illnesses and the treatment options -- medication versus (at your young age) possible curative transplant Rx. ...Read more
After a stem cell transplant 15 years ago, my BCR-ABL blood test is again positive for CML.
What do you suggest as the best medication on the market?
Oncologist: I suggest which ever medications your oncologist recommends. ...Read more
Urine test: Urinanalysis is test commonly done to check for infection, blood, sugar, ketones etc. The reflex microscopic portion is done automatically if the initial test shows any abnormality. For example, if there are signs of infection, then technicians will automatically look at the specimen under the microscope to see if there are any bacteria. This helps to decide on further testing and treatment. ...Read moreSee 1 more doctor answer
High normal: A TSH of 4.06 is in the upper range of normal. The lab probably did not do the ft4 level, since the TSH was normal. Most people with these results feel perfectly normal. However, it could be a sign that your thyroid is starting to fail. It would be reasonable to repeat the TSH and do a free T4 level in a few months. ...Read more
HYPOTHRYOID: Your thyroid gland is underactive it is not producing enough thyroxine. The pituitary gland is working overtime to try to get the thyroid gland to produce enough thyroxine which regulates the bodies metabolic rate. You need supplementation of what your gland produces. You also need to be checked for autoimmune thyroiditis, see your doctor. ...Read more
Borderline: That is a borderline pisitive result. Why was the tedt ordered in an 80 year old. ...Read more
Hypothyroidism: Normal TSH is typically 0.45-4.5. Best to discuss results w/ordering physician as some labs have different reference ranges. Regardless, if you have signs & symptoms of hypothyroidism (underactive thyroid = http://www.mayoclinic.org/diseases-conditions/hypothyroidism/basics/definition/con-20021179), prescription levothyroxine will help relieve symptoms but requires close & regular monitoring. ...Read moreSee 1 more doctor answer
Normal: This is a completely normal TSH. The free T4 was not done because the TSH was normal indicating normal thyroid function and the FT4 is not indicated. There are some rare circumstances when you would do both, and not just the reflex, but in general a normal screening TSH means normal thyroid function. Anything else would specifically being looked for and thyroid testing can rarely be complicated. ...Read more
Normal: That's a normal value. That's why they didn't have to run the free t4. Reflex means they will run ft4 only if tsh is abnormal. ...Read more
Thyroid tests: It is advised that you would benefit from an online consultation to review your labs as well as past medical history and discuss your specific symptoms. A physician can help you understand the labs, correlate with your history and make recommended next steps. ...Read more
My tsh, w/reflex to FT4 results was 4.53 and a month later was 4.49. Do I neef to be on medication?
It is better: if you stay on it for a while. Endocrinologist like tsh between .3-3 not .5-5. Discuss with your doctor and see what your doctor will say. ...Read more
5 yr son w/sensory eating disorder.Bad gag reflex.OT w/no results.What can I do to help? Will he grow out of it? Going on for 4 years now. Any advice?
Can you define more?: What is at the root of his "bad" gag reflex? Do you mean he has a very STRONG or hypersensitive reflex to the point of not allowing anything into his mouth without either gagging or throwing up? Or do you mean that he has a poor gag reflex meaning that virtually NOTHING can gag him that goes into his mouth? And they've been working stringently with him for 4 years now without results? ...Read more
Many Things: This type of test is done for many types of infections, especially viruses or pertussis. In order to give you mroe information, I would need to know what specifically they were doing the test to check on. ...Read more
Tsh w/ reflex test read 1.20 and the range was 0.27- 4.20. Is this low norm or healthy norm? I was already diagnosed with hypo earlier this yr.
Need more info: The TSH level needs to be looked at in the context of your other thyroid levels. If you are not on any medication this might be interpreted as normal but your level of free T4 and free T3 (liothyronine) as well as your thyroid antibodies need to be analyzed as well. If your free T4 and/or free T3 (liothyronine) levels are low, then the TSH level might not be reflecting exactly what is going on with your thyroid. ...Read more
6 yo w/sensitive gag reflex. got a mouthful of water today at pool & vomited right away. This was 3 hrs ago. Seems fine now. Coughed 2x since. Worry?
If symptoms persist: If child is not having ongoing symptoms such as cough, choking, difficulty breathing, child is okay. Key to observe child over the next 24 hours. If symptoms of cough, choking or difficulty breathing occur, child needs evaluation in emergency room. Dry drowning and/or secondary drowning is very rare. ...Read more
- Talk to a doctor live online for free
- Bcr/abl rearrangement
- Bcr abl gene rearrangement qt pcr
- Fluorescence in situ hybridization cml/all, bcr/abl trans 9,22
- Ask a doctor a question free online
- Drvvt scr w reflex drvvt confirm
- Kappa lambda w ratio and reflex
- Chikungunya abs w reflexs to titer
- Clostridium diff cult w reflex
- Bcr/abl rearrangement with reflex