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Doctor insights on: Bcr Abl Gene Rearrangement Qt Pcr

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I had unprotected oral sex on me I saw no blood I have no sores I am circumsized I have tooken a HIV dna pcr test at 18 days and a 46 also a 4 week and 6 week duo test and a 8 week rapid test am I ok?

I had unprotected oral sex  on me I saw no blood I have no sores I am circumsized I have tooken a HIV dna pcr test at 18 days and a 46 also a 4 week and 6 week duo test and a 8 week rapid test am I ok?

You're OK: Oral sex is safe sex for HIV, with no proved transmissions by fellatio from mouth to penis, only rare ones penis to oral. You didn't need testing on account of this event and for sure not the multiple expensive ones you had. But the results from that combination of tests are conclusive. For sure you didn't catch HIV during that exposure and no further testing is needed. Best wishes and stay safe! ...Read more

Polymerase Chain Reaction (Definition)

Polymerase chain reaction is a method of finding a specific piece of dna and copying it over and over again until there is enough to study. The technique allows a scientist to detect very small amounts of dna in a swab sample then reproduce enough of it to study it. It is very sensisitive for detecting the presence of certain bacteria and is also used in doing other ...Read more


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Can you tell me how I could introduce a mutation in my favorite gene using a PCR technique?

Can you tell me how I could introduce a mutation in my favorite gene using a PCR technique?

You cannot: You cannot mutate a given genes by PCR or any other method. Radiation and chemicals will induce mutations in some cells but the process is random and uncontrolled. ...Read more

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Can chronic myelogenous leukemia (bcr/abl) have any effect on cellular metabolism?

Can chronic myelogenous leukemia (bcr/abl) have any effect on cellular metabolism?

Why this question???: Unless you are doing some research yourself, this question has zero relevance for your/anyone's treatment for cml. So let us keep life simple and straightforward and not complicate it for all of us who are trying to help patients in desperate need for quick and simple guidance! ...Read more

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In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not please provide the corresponding treatment for the result?

In Bone marrow test BCR-ABL Translocation ratio is 56.31% is it serious condition or not  please provide the corresponding treatment for the result?

CML: Refer your test report for interpretation. This usually indicates a positive BCR-ABL translocation, specific for the diagnosis of CML (chronic myelogenous leukemia) in the right clinical presentation. CML is a very treatable disease now with oral pills such as Gleevec, Tasigna, (nilotinib) and Sprycel with very high response rate. Good luck! Of note, this can also occur in ALL. ...Read more

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If a person had bcr-abl in low amount in blood. Do they have cml?

Maybe not: It depends on the test. With fish a few positive cells out of 200 can be expected based on overlapping signal and the way the test is done. If the technique was pcr very low level positives have been seen in people without cml. ...Read more

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Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Years of persistent unknown luekocytosis(15-25k)&thrombosis(465-525).Jak2 and bcr-abl=negative. Et? Or what kind of "hidden" issue could be causative?

Many: There are many causes of this picture. Perhaps the most common is hidden infection or inflammation and iron deficiency. Other causes include chronic myeloid leukemia with other rare mutation, chronic neutrophilic leukemia, myelofibrosis, etc. You probably would benefit from hematology consultation. Lap score many be useful as well. ...Read more

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WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution

WBC Count is high,BCR-ABL Translocation ratio is 56.31% in bone marrow test. what is the exact problem? Please provide the solution

Demand an answer: You have chronic granulocytic leukemia or one of its close relatives and you should have been told. There's no "solution" in terms of an easy cure, but this is a manageable illness. You owe it to yourself both to get the full picture from your physicians, and read up on this family of illnesses and the treatment options -- medication versus (at your young age) possible curative transplant Rx. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more