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Doctor insights on: Bactrim Drug Interactions

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Have a 17-year-old taking Bactrim sulfamethoxazole tmp wondering if there will be any drug interaction if she takes an herbal allergy pill that I got at the health food center that has vitamin A , C, pantothenic acid , calcium , zinc, quercetin, n-acety

Have a 17-year-old taking Bactrim sulfamethoxazole tmp  wondering if there will be any drug interaction if she takes an herbal allergy pill that I got at the health food center that has  vitamin A , C, pantothenic acid , calcium , zinc, quercetin, n-acety

Probably OK, but...: I doubt there is any serious potential for an adverse interaction. However, one of the problems with "natural" medicines, herbal products, and nutritional supplements, etc is that their exact contents often are unknown, And even when known, there is little research on interations with other drugs. So hard to be certain -- but probably no problem. ...Read more

Dr. Thomas Inwood
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Drug Interaction (Definition)

When the combination of two agents cause an effect, intended or unintended, that would not have otherwise ...Read more


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I was just diagnosed with ca-mrsa and i'm scared since it is often resistant to drugs. I just started bactrim ds tonight. What are the chances of it not responding to any drug? How can you know if it's caught early enough? Thank you!

I was just diagnosed with ca-mrsa and i'm scared since it is often resistant to drugs. I just started bactrim ds tonight. What are the chances of it not responding to any drug? How can you know if it's caught early enough? Thank you!

Partially resistant: Ca MRSA is not particularly worse than having regular staph infection. It is not related to the flesh eating bacteria scare. The choice of antibiotics is limited, but generally the infection is sensitive to at least a few of the mainstream antibiotics of which Bactrim (sulfamethoxazole and trimethoprim) is one. If your doctor thought you were at great risk you would not be at home. ...Read more

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Switching antibiotics from bactrim to Cipro (cipro (ciprofloxacin)floxacin). Bactrim stopped last night/taken for 5 days. Is it ok to start cipro (ciprofloxacin) today or are there any interactions?

Switching antibiotics from bactrim to Cipro (cipro (ciprofloxacin)floxacin). Bactrim stopped last night/taken for 5 days. Is it ok to start cipro (ciprofloxacin) today or are there any interactions?

It is ok: You didn't say what you were taking the antibiotics for- I am assuming urinary tract infection? Also, I am assuming a medical provider told you to switch and start cipro (ciprofloxacin). If so - there are no significant interactions (as long as you're not allergic). ...Read more

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Is there any over-the-counter drug like bactrim (sulfamethoxazole and trimethoprim)?

No: In the usa antibiotics are not available over the counter. Excessive use of antibiotics leads to bacterial resistance. ...Read more

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Very allergic to sulfa drugs, took 1 Bactrim (sulfamethoxazole and trimethoprim) 800 in error. What should I do?

Very allergic to sulfa drugs, took 1 Bactrim (sulfamethoxazole and trimethoprim) 800 in error. What should I do?

Antihistamine helps: In such a situation, one can take antihistamines such as Benadryl, (diphenhydramine) Claritin, Allegra, or Zyrtec (all over-the-counter) and call her primary care doctor. What the doctor might do will likely depend on the type of reaction the patient has had in the past, how severe the reaction was, how fast the reaction happened, etc... Immediate, severe allergic reactions require an injection (EpiPen) and 911. ...Read more

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Can a person have a rash develop from bactrim (sulfamethoxazole and trimethoprim) a day after finishing a 7-day course of the drug?

Can a person have a rash develop from bactrim (sulfamethoxazole and trimethoprim) a day after finishing a 7-day course of the drug?

Probably > 1day.: A person can have a rash from Bactrim (sulfamethoxazole and trimethoprim) or any other drug, but it likely developed during the course of the drug, not after. It may have been too subtle at first, and could have been attributed to other things, like food allergy or contact allergy from clothes washed with a detergents that can cause a rash in those who are susceptable. ...Read more

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What is the chance of getting a 2nd bactrim (sulfamethoxazole and trimethoprim) rash. A month after using the drug and stopping because of the 1st rash the drug was ok for a year before?

What is the chance of getting a 2nd bactrim (sulfamethoxazole and trimethoprim) rash. A month after using the  drug and stopping because of the 1st rash the drug was ok for a year before?

High: You are likely developing a sulfa allergy, in which case the allergy (/rash) will show up quicker and more intensely with next exposure to it. Not recommended in general. ...Read more

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Why is there an interaction between Coumadin and bactrim (sulfamethoxazole and trimethoprim)?

Why is there an interaction between Coumadin and bactrim (sulfamethoxazole and trimethoprim)?

Increases free drug: Much of Coumadin is bound to protein. Many drugs, including bactrim, (sulfamethoxazole and trimethoprim) dislodge it from protein and increase the free (active) drug in the circulation. This usually results in a sharp spike in the inr and can lead to bleeding. If you must take batrim, you may need to skip a dose or two of coumadin. Discuss with your doctor. ...Read more

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Is there a negative interaction between bactrim (sulfamethoxazole and trimethoprim) ds and coumadin?

Is there a negative interaction between bactrim (sulfamethoxazole and trimethoprim) ds and coumadin?

Yes: Bactrim (sulfamethoxazole and trimethoprim) ds increases effects of Coumadin by decreasing metabolism, by plasma protein binding competiton, and through hepatic enzyme cyp2c9/10 metabolism. Significant interaction possible.Monitor closely. Use alternatives if available. ...Read more

Bactrim (Definition)

Trimethoprim and sulfamethoxazole, cotrimoxazole is a combination antibiotic that is used to treat a ...Read more