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Doctor insights on: Bactrim And Coumadin Interaction

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Why is there an interaction between Coumadin and bactrim (sulfamethoxazole and trimethoprim)?

Why is there an interaction between Coumadin and bactrim (sulfamethoxazole and trimethoprim)?

Increases free drug: Much of Coumadin is bound to protein. Many drugs, including bactrim, (sulfamethoxazole and trimethoprim) dislodge it from protein and increase the free (active) drug in the circulation. This usually results in a sharp spike in the inr and can lead to bleeding. If you must take batrim, you may need to skip a dose or two of coumadin. Discuss with your doctor. ...Read more

Warfarin (Definition)

Warfarin is a medication used to thin the blood and to prevent or treat people with blood clots. It requires frequent blood ...Read more


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Is there a negative interaction between bactrim (sulfamethoxazole and trimethoprim) ds and coumadin?

Is there a negative interaction between bactrim (sulfamethoxazole and trimethoprim) ds and coumadin?

Yes: Bactrim (sulfamethoxazole and trimethoprim) ds increases effects of Coumadin by decreasing metabolism, by plasma protein binding competiton, and through hepatic enzyme cyp2c9/10 metabolism.
Significant interaction possible. Monitor closely. Use alternatives if available. ...Read more

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Can you take bactrim (sulfamethoxazole and trimethoprim) and warfarin together?

Can you take bactrim (sulfamethoxazole and trimethoprim) and warfarin together?

No: Drug-drug interaction: Bactrim (sulfamethoxazole and trimethoprim) delays the hepatic metabolism of coumadin, thereby prolonging the inr/protime and bleeding risks. ...Read more

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Can there be some interaction between Coumadin (warfarin) therapy and apple cidere vinegar?

Can there be some interaction between Coumadin (warfarin) therapy and apple cidere vinegar?

No interaction known: I'm not a fan of Coumadin because almost every drug & many foods & herbs interact with it, but there are no known interactions between Coumadin & any vinegars- this doesn't mean there can't be-I saw a report from 1 person saying it increased their INR- so use caution. See http://www. Drugs. Com/food-interactions/warfarin. Low doses of Vitamin K can stabilize INR levels:
http://tinyurl. Com/hw6e2uu ...Read more

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Switching antibiotics from bactrim to Cipro (cipro (ciprofloxacin)floxacin). Bactrim stopped last night/taken for 5 days. Is it ok to start cipro (ciprofloxacin) today or are there any interactions?

Switching antibiotics from bactrim to Cipro (cipro (ciprofloxacin)floxacin). Bactrim stopped last night/taken for 5 days. Is it ok to start cipro (ciprofloxacin) today or are there any interactions?

It is ok: You didn't say what you were taking the antibiotics for- I am assuming urinary tract infection? Also, I am assuming a medical provider told you to switch and start cipro (ciprofloxacin). If so - there are no significant interactions (as long as you're not allergic). ...Read more

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Have a 17-year-old taking Bactrim sulfamethoxazole tmp wondering if there will be any drug interaction if she takes an herbal allergy pill that I got at the health food center that has vitamin A, C, pantothenic acid, calcium, zinc, quercetin, n-acety

Have a 17-year-old taking Bactrim sulfamethoxazole tmp wondering if there will be any drug interaction if she takes an herbal allergy pill that I got at the health food center that has vitamin A, C, pantothenic acid, calcium, zinc, quercetin, n-acety

Probably OK, but...: I doubt there is any serious potential for an adverse interaction. However, one of the problems with "natural" medicines, herbal products, and nutritional supplements, etc is that their exact contents often are unknown, And even when known, there is little research on interations with other drugs. So hard to be certain -- but probably no problem. ...Read more

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Are there any interactions between bactrim (sulfamethoxazole and trimethoprim) and olive leaf extract? Or can I take them simultaneously? Also, Bactrim (sulfamethoxazole and trimethoprim) & garlic extract/monoluarin?

Are there any interactions between bactrim (sulfamethoxazole and trimethoprim) and olive leaf extract? Or can I take them simultaneously? Also, Bactrim (sulfamethoxazole and trimethoprim) & garlic extract/monoluarin?

Most important thing: You must know when taking Bactrim (sulfamethoxazole and trimethoprim) is that it can form crystals in your kidneys if you don't hydrate enough. So taking larges amount of filtered water to protect your kidneys is paramount. Olive leaf extract which is the heart of the mediterranean diet should not pose a problem, but it's always good to take your supplements separately from your medications in general. You can take UR supplements. ...Read more

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Takn Coumadin (warfarin) hvn't ben able 2eat much lately&have los 8+lbs n 2wks I don't know y. But got INR checked 2day & it was 6.1y? Is this dangerous menstrualonalso

Takn Coumadin (warfarin) hvn't ben able 2eat much lately&have los 8+lbs n 2wks I don't know y. But got INR checked 2day & it was 6.1y? Is this dangerous menstrualonalso

Go see your doctor..: Now! You didn't explain why you're taking Coumadin (warfarin) but we typically aim for inr 2-3 if for blood clot or atrial fibrillation or clotting disorder. We aim for 2.5-3.5 if you have mechanical valve. Inr of 6.1 is way too high. Your Coumadin (warfarin) dose needs to be held/adjusted & inr monitored closely until back into therapeutic range. 8 lb weight loss in 2wks is not normal either. Go see your doctor now! ...Read more

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How effective is Coumadin (warfarin)?

How effective is Coumadin (warfarin)?

Quite effective: It requires monitoring of INR to make sure that the dose is appropriate. New anticoagulants don't require monitoring ...Read more

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What's the maximum dosage of coumadin (warfarin)?

What's the maximum dosage of coumadin (warfarin)?

Varies: I love dr. Klein's answer: "the dose that works." he is absolutely right. Certain south-east Asian populations have the genetics he mentioned that makes them require higher doses of Coumadin (warfarin) than others the same weight. Generally, smaller people need less than larger, too, but not always. Diet has a lot to do with dosage need. ...Read more

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What are the alternatives to coumadin (warfarin)?

Coumadin (warfarin): For atrial fibrillation there are direct thrombin inhibitors approved for stroke prevention. These are not approved for patients with mechanical valves. ...Read more

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Please describe the medication: coumadin (warfarin)?

Anticoagulant: Coumadin also called as warfarin is a medication commonly used to prevent blood from clotting. It requires monitoring of inr (international normalized ratio) to make sure that dose is adequate for patient and disease entity it is prescribed for. ...Read more

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What happens if you take too much coumadin (warfarin)?

Bleed: Coumadin (warfarin) is rat poison. It is used as an anticoagulant for certain medical conditions. The levels are closely monitored by your doc. Too much can thin you blood and could cause you to bleed and lose a lot of blood with its own consequences. ...Read more

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How often should I have my Coumadin (warfarin) levels checked?

How often should I have my Coumadin (warfarin) levels checked?

That is a: Tough one. In general frequent testing is needed to get I right at the outset. After that increased monitoring is needed with change in health status, especially new mess which may interact. ...Read more

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What are the different doses that Coumadin (warfarin) comes in?

What are the different doses that Coumadin (warfarin) comes in?

Many doses: Coumadin (warfarin) comes in a variety of doses: l mg, 2 mg, 4 mg, 5 mg, etc. Because a person may need to adjust doses from time to time, patients may need to have a variety of tablets on hand so they can make easy adjustments at the recommendation of their doctor or coagulation clinic. Coumadin (warfarin) interacts with a variety of medications and even the food we eat, so it's not uncommon to require fine tuning. ...Read more

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How often should you have your Coumadin (warfarin) levels checked?

Depends: Great question; if you are on the medication longterm most healtcare providers check protimes/inrs every month. In the most recent guidelines, however, some organizations are suggesting that every three months may be just as good. ...Read more

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What happens if I accidently took a Coumadin (warfarin) at 5:30pm and then again at 7:45 am.?

What happens if I accidently took a Coumadin (warfarin) at 5:30pm and then again at 7:45 am.?

Higher INR: Your protime/inr will likely go higher for the next day or 2. Let your doc know about the extra dose, and he may recommend an inr check, or simply holding a dose. This will depend on your previous baseline and why you are on coumadin (warfarin). ...Read more

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Zinc interfere with coumadin (warfarin)?

No: There are no interactions that I am aware of. However, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist. ...Read more

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Is 7mg a high dose for coumadin (warfarin)?

Is 7mg a high dose for coumadin (warfarin)?

Not Really: Some patient require higher dose as hepatic metabolism is variable. Also, intake of vitamin k containing food will impact Coumadin (warfarin) dose. ...Read more

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Common side effects of coumadin (warfarin)?

Common side effects of coumadin (warfarin)?

Bleeding.: This medication can cause serious bleeding if it affects your blood clotting proteins too much (shown by unusually high inr lab results). Even if your doctor stops your medication, this risk of bleeding can continue for up to a week. Tell your doctor right away if you have any signs of serious bleeding, including: unusual pain/swelling/discomfort/easy bruising, prolonged bleeding from cuts. ...Read more

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Does hoodia interfere with coumadin/warfarin?

Does hoodia interfere with coumadin/warfarin?

No: I can find no report of a drug interaction. You should be aware that many products marketed as hoodia actually have no hoodia in them. ...Read more

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Possible side effects of coumadin (warfarin)?

Bruising, bleeding: The most common side effects of Coumadin (warfarin) are bruising and bleeding. Coumadin (warfarin) affects other medicines and can make them work more or less well than normal. Coumadin (warfarin) can also increase the side effects caused by other drugs. You have to be careful about what you eat with Coumadin (warfarin) and make sure you aren't getting too much vitamin k in your diet since it can counteract the effectiveness of coumadin, (warfarin). ...Read more

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Can I use alegra d if I'm in coumadin (warfarin)?

Can I use alegra d if I'm in coumadin (warfarin)?

AllegraD / warfarin: I can find no warnings in the epocrates database for either fexfenadine or pseudoephedrine, the two ingredients in Allegra (fexofenadine) d regarding interactions with warfarin (coumadin). But just to be sure, check with your pharmacist and your cardiologist. If you are taking Coumadin for a heart condition, your doctor might prefer you take plain allegra (fexofenadine). The d part, sudafed, is a cardiac stimulant. ...Read more

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Do you have to be weaned off coumadin (warfarin)?

No: Depending on why you're on it? But no it does not have to be weaned. ...Read more

Bactrim (Definition)

Trimethoprim and sulfamethoxazole, cotrimoxazole is a combination antibiotic that is used to treat a ...Read more


Dr. Ted King
699 Doctors shared insights

Coumadin (Definition)

Coumadin is an anticholinergic agent which is a kind of anti-Parkinson's drug ...Read more