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Doctor insights on: Azopt Ocular Carbonic Anhydrase Enzyme Blocker

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Beta blocker with diuretic (timolide) effective?

Beta blocker with diuretic (timolide) effective?

Modestly: Most beta-blocker and diuretic combinations we're formulated for use in mild hypertension. ...Read more

Enzyme (Definition)

An enzyme causes the transformation of a compoond to another compound. In living structures, it is the transformation of a protein to another form. An example is from an inactive state ...Read more


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Can succinylcholine drugs (nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure? Any answers appreciated!

Can succinylcholine drugs (nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure? Any answers appreciated!

No.: Succinylcholine actually causes an increase in intraocular pressure for about 10 minutes after administration. Classic teaching was not to use succ in people with open globe injuries. There are situations, though, where using succ with other agents that lower IOP is preferred because it makes intubation more smooth, avoiding hypertension and airway reactivity that is worse for the situation anyway ...Read more

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Has anyone tried carbonic anhydrase inhibitors?

Has anyone tried carbonic anhydrase inhibitors?

Helpful drug: Carbonic anhydrase inhibitors (cai) are used mainly to treat two conditions: glaucoma and altitude sickness. They are useful in both conditions and actually mandatory for high altitude climbing. There are side effects from chronic use, mainly kidney stones. Discuss this will your doctor if you think you need them. ...Read more

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

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Is it possible that succinylcholine drugs(nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure?

Is it possible that succinylcholine drugs(nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure?

No: Succinylcholine is known to increase intraocular minimally when given to secure the airway. The increase is small and passing, therefore it has been used in patients with increased intraocular pressure. ...Read more

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How can the therapeutic effects of antacid drugs, h2 blockers, proton pump inhibitor drugs, misoprostol?

How can the therapeutic effects of antacid drugs, h2 blockers, proton pump inhibitor drugs, misoprostol?

Question?: I'm not sure I fully understand what your question is? The drugs you listed all help with symptoms of GERD or stomach ulcers, and they have different means by which they help patients with these problems. The safest and easiest to take are antacids and H2 blockers. Please consider rephrasing your question more specifically. ...Read more

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Do selective adeno-adenergic blockers (prazosin, terazosin, doxazosin, trimazosin) protect  from acute cocaine-induced vasoconstrictive damage?

Do selective adeno-adenergic blockers (prazosin, terazosin, doxazosin, trimazosin) protect  from acute cocaine-induced vasoconstrictive damage?

Some: Cocaine causes it's effect by preventing the reuptake of monamine (epinephrine, etc) and causes these neurotransmitters to continue exciting the a1 receptor. The meds listed block alpha-1 receptors, so theoretically will blunt the effects of Cocaine on some vessels, but focus mostly (esp. Tamsulosin) on a specific sub-type (alpha-1a) that is mostly in the bladder, not in the vessels. ...Read more

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Which of this three medication give glaucoma: alphagan (brimonidine) or timolol maleate?

Which of this three medication give glaucoma: alphagan (brimonidine) or timolol maleate?

This treats glaucoma: Timolol maleate is the generic name of one medicine, timoptic (timolol). Alphagan is another medication to treat glaucoma. They can be used in combination. ...Read more

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Are beta blockers & calcium channel blockers truly contradicted in Wolff-Parkinson-White patients?

Are beta blockers & calcium channel blockers truly contradicted in Wolff-Parkinson-White patients?

Yes: In patients with wolff-parkinson-white especially those who have a history of atrial fibrillation or flutter, beta blockers and calcium channel blockers, which are av nodal blocking agents especially Diltiazem and verapamil, should be avoided. ...Read more

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Dear doc, is cod liver oil safe to take with: 1. bp meds (beta blockers, calcium channel blockers) 2. proton pump inhibitors & 3. VitD3 supplements?

Dear doc, is cod liver oil safe to take with: 
1. bp meds (beta blockers, calcium channel blockers)
2. proton pump inhibitors & 
3. VitD3 supplements?

Yes: It's fine to take with the blood pressure medications and the proton pump inhibitor. I would probably stop the vitamin D supplement as cod liver oil has vitamin A and D as the main vitamin sources. Vitamin D is one you can get in trouble with because it is fat soluble and can accumulate in your organs if you take too much. ...Read more

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Beta blocker with diuretic (timolide 10/25)--whats the use?

Beta blocker with diuretic (timolide 10/25)--whats the use?

Modestly: Most beta-blocker and diuretic combinations we're formulated for use in mild hypertension. ...Read more

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Do any beta blockers act on Central Nervous System? Labetalol, Propranalol? What about Alpha-1 blockers?

Do any beta blockers act on Central Nervous System?  Labetalol, Propranalol? What about Alpha-1 blockers?

Yes, most of them: Beta blockers are either water soluble or lipid soluble. The latter cross the blood-brain barrier and act on the CNS (central nervous system). Atenelol and Naldolol are 2 water soluble ones that do not readily cross into the brain. Alpha blockers generally do act on the CNS, and the 2 most common side effects are hypotension and dizziness. ...Read more

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Resistant pulmonary htn due to sjogrens. Norvasc (amlodipine) works but isosorbide unpredictable. Beta blocker worsens. Arb acs contraindicated ckd high K. Advice?

Resistant pulmonary htn due to sjogrens. Norvasc (amlodipine) works but isosorbide unpredictable. Beta blocker worsens. Arb acs contraindicated ckd high K. Advice?

Pulmonary HTN: There are a range of molecules available by prescription that address P HTN ;go see a cardiologist or pulmonologist that has an interest in treating this condition ...Read more

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I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?

I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?

Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more

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Has anyone used lipase inhibitors (orlistat) the fat blocking medication?

Has anyone used lipase inhibitors (orlistat) the fat blocking medication?

Yes: When it first came out. My patients did and they did not want it anymore. ...Read more

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What is the differences between brinzolamide and dorzolamide as topical eye drops with timolol for reducing ocular hypertension?

What is the differences between  brinzolamide and dorzolamide as topical eye drops with timolol for reducing ocular hypertension?

Same: Brinzolamide and dorzolamide are both carbonic anhydase inhibitors. They lower pressure by stopping the enzyme that helps produce fluid in the eye. They are both sulfa compound derivatives. ...Read more

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I want to know what is the function of carbonic anhydrase in the brain.

I want to know what is the function of carbonic anhydrase in the brain.

Acid-base regulation: Carbonic anhydrase (CA) is found throughout the brain. It is concentrated in the areas producing cerebro-spinal fluid and helps maintain that pressure. But all cells have this important enzyme involved in keeping the acid-base balance of the brain and body. ...Read more

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Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Are there are Foods/minerals/supplements which are natural Carbonic Anhydrase Inhibitors?

Yes: Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate (sodium bicarbonate) and a proton (hydrogen ion.) Resveratrol, catechin, silymarin, and curcumin are natural products known as polyphenols. Resveratrol comes from red wine. Catechin is found in tea. Silymarin is an extract of milk thistle. ...Read more

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Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Is it true Thiamine is a carbonic anhydrase inhibitor (seen a couple of studies) and if so, could it be helpful in idiopathic intracranial hypertensio?

Maybe: The science is a bit sketchy, and mostly Internet based, which does cast suspicion on validity, but seems to be some possible mechanisms by thiamine on CO2 metabolism. If pseudo tumor is present, would certainly try Diamox (acetazolamide) or glycerol, but would not hurt to add thiamine (vitamin B-1), but would not use B-1 exclusively, as I am not convinced of its efficacy. ...Read more

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Has anyone tried carbonic anhydrase inhibitors?

Helpful drug: Carbonic anhydrase inhibitors (cai) are used mainly to treat two conditions: glaucoma and altitude sickness. They are useful in both conditions and actually mandatory for high altitude climbing. There are side effects from chronic use, mainly kidney stones. Discuss this will your doctor if you think you need them. ...Read more

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Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?

Has anyone with paramyotonia congenita and hyperkalemic periodic paralysis used carbonic anhydrase inhibitors?

Channelopathies: Your question is interesting. Here is a reference that answers it: channelopathies. Moxley iii rt. Curr treat options neurol. 2000 jan;2(1):31-47. Pmid: 11096735 [pubmed - as supplied by publisher] in short, yes. Longer answer, in some situations it can help, in others, it can make matters worse. The reasons are not understood. Go to pubmed and search for that article, then read the abstract. ...Read more

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I have paramyotonia congenita and hyperkalemic periodic paralysis and want to try carbonic anhydrase inhibitors?

Then by all means: speak to your neurologist. We all have to learn about these condition, frankly, they are heavily tested on our board exams; however, rarely actually seen. I'd consider seeing a neurologist with expertise in neuromuscular disorders. ...Read more

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I've read studies that high doses of thiamine can be as effective as acetezolomide in terms of Carbonic anhydrase inhibitor. True? I have IIH.

Maybe so: I can confirm that I have also read studies that suggest that thiamine is a significant carbonic anhydrase inhibitor. Considering the seriousness of the condition that you are treating, you should probably stick with the known effect of diamox (acetazolamide). However, you could discuss this with your treating physician. ...Read more

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Will latisse have interactions with other medications i take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Will latisse have interactions with other medications i take? I'm on an oral carbonic anhydrase inhibitor for glaucoma. Will using latisse have any adverse affect or interaction? Are there other medications or ointments that might be a problem if used tog

Should : Should not have any adverse affect but may result in an even lower eye pressure. You may see if you eye doctor can switch you form the carbonic anydrase inhibitor to Lumigan eye drops which will help the glaucoma and your lashes at the same time (lumigan and Latisse (bimatoprost) are the same medicine). ...Read more

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Are there natural sources of Carbonic Anhydrase Inhibitors? I've read pomegranate, milk thistle and turmeric are? True?

Verify your sources: Sadly, despite a huge level of interest in the medicinal properties of foods, or maybe because of it, there is an enormous amount of false, half true, or exaggerated information on the internet. In regards to CAI in Pomegranate, I found a review article in an Iranian pharmacy journal that cited 2 chemistry review articles, neither of which makes any mention of Pomegranate whatsoever. ...Read more

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I have Pseudotumor Cerebri. I've read Pomegranate, milk thistle, turmeric, capsaicin all hold Carbonic Anhydrase Inhibitors naturally. Is this true?

Use with care: I can confirm that pomegranate and turmeric contain some carbonic anhydrase inhibitor activity. However, these do not have enough of this to be clinically useful. It is much more straightforward to take a small dose of diamox (acetazolamide) instead. Although it does not work for everyone with PTC, it helps many. The side effects would be the same if the medicine dose was the same. ...Read more

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Is it safe to take azopt while pregnant or breastfeeding?

Is it safe to take azopt while pregnant or breastfeeding?

No: As a generalization most eye drop medications are safe to use in pregnancy. Consider calling the teratogen hot-line: (800) 532-3749. ...Read more

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What is the definition or description of: Azopt allergy?

What is the definition or description of: Azopt allergy?

Azopt allergy: Brinzolamide (Azopt) is a medication used for the treatment of Glaucoma. An allergy occurs when your body’s immune system creates antibodies to a foreign substance causing a reaction that can be mild to severe. See: https://www.drugs.com/sfx/azopt-side-effects.html ...Read more

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Can children use Azopt?

Can children use Azopt?

What for?: It is used for ocular hypertension or open-angle glaucoma, non of which occurs on childhood except in certain cases, hence it would be warranted and a doctor would prescribe it ...Read more

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Are there any other alternative drugs to substitute for azopt?

Are there any other alternative drugs to substitute for azopt?

Yes: Azopt is an ocular hypotensive agent used to reduce eye pressure. There are other drugs in this class and also several other classes of drugs which can be used for this purpose. In some cases, laser procedures can be preformed so that topical medication is no longer needed. Speak to your eye doctor about alternatives. ...Read more

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Who should not use Azopt?

Azopt: "AZOPT® (brinzolamide ophthalmic suspension) 1% is contraindicated in patients who are hypersensitive to any component of this product." See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e9ea2ae7-1b98-4034-9fba-8ce2225e0145 ...Read more

Dr. Sheila Smith
7 doctors shared insights

Azopt (Definition)

Azopt is an ocular carbonic anhydrase enzyme blocker which is a kind of ...Read more


Dr. Steven Griggs
7 doctors shared insights

Brinzolamide (Definition)

Brinzolamide is a rhythm control agent which is a ...Read more