Doctor insights on:
Azathioprine Transplant Will Harm Liver
Too much is never OK: Too much of any medicine may cause toxicity. Azathioprine can cause liver dysfunction in a small number of patients, and when you take this drug it is standard to monitor your liver function tests. Sometimes dose adjustments need to be made. ...Read moreSee 1 more doctor answer
This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more
Inhibits DNA : Azathioprine (aza) is a nucleoside analogue that inhibits dna production. It affects rapidly proliferating cells such as b cells and t cells and thus is an immunosuppression agent. In transplantation aza has mostly been replaced by the similar but more efficacious agent Mycophenolic Acid sold as cellcept (mycophenolate mofetil). Both aza and CellCept (mycophenolate mofetil) are used with other immunosuppression agents and are not used alone. ...Read more
OK, but not great: Azathioprine (aza) was the mainstay of drug therapy from the early 1960's to the early 1980's. It works primarily by preventing t-cells from getting excited, multiplying, and attacking the graft. One-year graft survival using aza was approximately 50% while more modern drugs used today result in 95% survival. ...Read moreSee 1 more doctor answer
Is it safe to take Clenbuterol while using Imuran (azathioprine)? Taking Imuran (azathioprine) to treat chronic liver decease
Yes: The two well not interfereGet a more detailed answer ›
Benefits vs risks: Agree with drs. Layman and browne. Unfortunately, the cost of immune suppression is increased risk for infections and some cancers, especially skin, lymphoma, others. Balance that with the risk to life and health of not getting the transplant, if needed, e.g.Kidneys-lifelong dialysis (with associated risks); liver- liver failure (not pretty), early death, ;heart-congestive failure and early death. ...Read moreSee 2 more doctor answers
How long does it take for blood counts and liver enzymes to return back to normal after stopping imuran (azathioprine) ?? And how long will side effects reverse ?
Within 1-3 months: Imuran (azathioprine) is a drug used to suppress the immune system in many diseases. Monitoring liver function tests is used to detect hepatotoxicity, generally defined as elevated AST/ALT greater than twice normal. Dose reduction or split dosing, or use of allopurinol may minimize hepatoxicity, but the vast majority of patients will reverse the liver injury within 1-3 months after discontinuation of Imuran (azathioprine) ...Read more
How does azathioprine effect the liver? They did bloods test and somthing rised a bit to do with myliver
Toxicity : Azathioprine can cause self limiting increases in liver function tests for which nothing needs to be done. However, the medication can also cause acute and chronic toxicities and depending on how long a patient is taking the drug, can manifest with liver scarring and drainage issues (cholestasis). I recommend having your liver function tests tested several times over the next year or so. ...Read more
I am on imuran (azathioprine) and have developed itching all over (no rash). It has been about 6 months since my last liver enzyme testing. I have heard that itching can happen with liver issues. Should i be worried?
I have Crohn's and have been on pentasa, (mesalamine) humira and imuran which severely increase my liver enzymes. Would remicade be less liver toxic then imuran?
In medicine: a transfer from one body or body part to another of an organ (liver, heart, lung, kidney, pancreas bowel) or tissue (hand, face, hair). The immune system fights foreign invaders (like infections) so it will reject transplants from other people (allotransplants) because they look like infections. So transplants usually require drugs to ...Read more
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