Top
10
Doctor insights on: Azathioprine Transplant Will Harm Liver

Share
1

1
If I take too much azathioprine for my transplant, will it harm my liver?

If I take too much azathioprine for my transplant, will it harm my liver?

Too much is never OK: Too much of any medicine may cause toxicity. Azathioprine can cause liver dysfunction in a small number of patients, and when you take this drug it is standard to monitor your liver function tests. Sometimes dose adjustments need to be made. ...Read more

See 1 more doctor answer
Dr. Milroy Samuel
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


2

2
What is the mechanism of action of azathioprine before and after renal transplantation?

What is the mechanism of action of azathioprine before and after renal transplantation?

Inhibits DNA : Azathioprine (aza) is a nucleoside analogue that inhibits dna production. It affects rapidly proliferating cells such as b cells and t cells and thus is an immunosuppression agent. In transplantation aza has mostly been replaced by the similar but more efficacious agent Mycophenolic Acid sold as cellcept (mycophenolate mofetil). Both aza and CellCept (mycophenolate mofetil) are used with other immunosuppression agents and are not used alone. ...Read more

3

3
How does azathioprine work after a renal transplantation?

OK, but not great: Azathioprine (aza) was the mainstay of drug therapy from the early 1960's to the early 1980's. It works primarily by preventing t-cells from getting excited, multiplying, and attacking the graft. One-year graft survival using aza was approximately 50% while more modern drugs used today result in 95% survival. ...Read more

See 1 more doctor answer
5

5
Can I get cancer from taking azathioprine for my organ transplant?

Can I get cancer from taking azathioprine for my organ transplant?

Benefits vs risks: Agree with drs. Layman and browne. Unfortunately, the cost of immune suppression is increased risk for infections and some cancers, especially skin, lymphoma, others. Balance that with the risk to life and health of not getting the transplant, if needed, e.g.Kidneys-lifelong dialysis (with associated risks); liver- liver failure (not pretty), early death, ;heart-congestive failure and early death. ...Read more

See 2 more doctor answers
6

6
How long does it take for blood counts and liver enzymes to return back to normal after stopping imuran (azathioprine) ?? And how long will side effects reverse ?

Within 1-3 months: Imuran (azathioprine) is a drug used to suppress the immune system in many diseases. Monitoring liver function tests is used to detect hepatotoxicity, generally defined as elevated AST/ALT greater than twice normal. Dose reduction or split dosing, or use of allopurinol may minimize hepatoxicity, but the vast majority of patients will reverse the liver injury within 1-3 months after discontinuation of Imuran (azathioprine) ...Read more

7

7
How does azathioprine effect the liver? They did bloods test and somthing rised a bit to do with myliver

How does azathioprine  effect the liver? They did bloods test and somthing rised a bit to do with myliver

Toxicity : Azathioprine can cause self limiting increases in liver function tests for which nothing needs to be done. However, the medication can also cause acute and chronic toxicities and depending on how long a patient is taking the drug, can manifest with liver scarring and drainage issues (cholestasis). I recommend having your liver function tests tested several times over the next year or so. ...Read more

Dr. Ravi Chand
3 doctors shared insights

Transplant (Definition)

In medicine: a transfer from one body or body part to another of an organ (liver, heart, lung, kidney, pancreas bowel) or tissue (hand, face, hair). The immune system fights foreign invaders (like infections) so it will reject transplants from other people (allotransplants) because they look like infections. So transplants usually require drugs to ...Read more


Dr. Amy Friedman
1,093 doctors shared insights

Transplantation (Definition)

Transplantation is the process of transplanting organs from a donor to a recipient and includes surgery ...Read more