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Doctor insights on: Avastin And Temodar Combination

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Can Abraxane and Avastin (bevacizumab) be used for treating ovarian cancer?

Can Abraxane and Avastin (bevacizumab) be used for treating ovarian cancer?

Yes it is an option: The standard therapy for ovarian cancer initially is still a taxane (usually Taxol) and Carboplatin. However, Abraxane is an effective taxane down the line for recurrences, and is potentially less toxic. Avastin (bevacizumab) has been combined safely with Abraxane and the two may be helpful for recurrence management. But the question is a bit difficult to answer concretely because circumstances differ. ...Read more

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Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Why has the drug temozolomide replaced the combination of procarbazine, carmustine and vincristine?

Newer treatment: In treatment of Cancer, newer drugs come along and are then compared to the standard(old/conventional treatments). If the new treatment if better(more effective or less toxic) then the new drug takes over and the older drugs put on the back burner. That is what has happened in this instance. This is what has happened in the treatment of brain tumors. ...Read more

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How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

See below: It is not a curall for colon cancer but is effective therapy to a large extent it depends onthe size and wehre it is. Almost certianly it requires more than this drug to get a cure if acure is possible. ...Read more

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Which is more effective: Avastin (bevacizumab) or Erbitux?

Which is more effective: Avastin (bevacizumab)  or Erbitux?

Identical: Data on Bevacizumab or Erbitux in patients with metastatic colorectal cancer, patients who do not have a KRAS 12/13 gene mutation, have nearly identical survival rates. These identical results were seen after chemotherapy, where survival with chemo alone was about 5 months vs. 7-8 months using either bevacizumab (Avastin) or cetuximab (Erbitux). ...Read more

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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer?

Is combined tamoxifen plus hormonal therapy better for breast cancer?

No: Studies show that adding tamoxifen to an aromatase inhibitor (what i assume you mean by "hormonal therapy") was not better than either drug alone. ...Read more

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Has anyone used peginterferon alpha 2B and temezolomide for melanoma?

Has anyone used peginterferon alpha 2B and temezolomide for melanoma?

Alone or in combo?: Both of these drugs have been used separately to treat metastatic or high risk melanoma. However, the combination of these two drugs must be considered experimental, without even knowledge of safe doses let alone efficacy. ...Read more

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Starting temodar (temozolomide) prescription for treatment of anaplastic astrocytoma brain tumor. What are strange side effects?

Starting temodar (temozolomide) prescription for treatment of anaplastic astrocytoma brain tumor. What are strange side effects?

Not strange: Temodar, (temozolomide) like other chemotherapy agents, may cause nausea and vomiting, may cause a general sense of "malaise", and will have a risk of lowering your white blood cell counts and making you more susceptible to certain infections. It is generally well-tolerated however, more so than most other agents used for astrocytomas. There are no "strange" side-effects that i know of. Talk to your doctors. ...Read more

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What are side effects of adjuvant and neoadjuvant therapy?

What are side effects of adjuvant and neoadjuvant therapy?

Side effects: Side effects are same either neo or adjuvant. It also depends on type of therapy use. Nausea, vomiting, hair loss, lowering blood counts, lower immunity and some specific effects related to type of chemo. ...Read more

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Using avastin (bevacizumab) for macula degeneration treatment?

Using avastin (bevacizumab) for macula degeneration treatment?

Avastin (bevacizumab): Avastin (bevacizumab) is a drug that is commonly used in the treatment of wet macular degeneration and other eye conditions involving leakage of fluid from blood vessels in the retina. ...Read more

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What are the side effects of Xeloda (capecitabine) and neotherapy for cancer?

What are the side effects of Xeloda (capecitabine) and neotherapy for cancer?

Xeloda (capecitabine): http://www.nlm.nih.gov/medlineplus/druginfo/meds/a699003.html if any concern, please see your oncologist and discuss further with your md. ...Read more

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How effective is the IFL-Bevacizumab chemotherapy regimen for treating colon cancer?

How effective is the IFL-Bevacizumab chemotherapy regimen for treating colon cancer?

Better than chemo: Combining bevacizumab (BV)—a recombinant, humanized mAb targeting VEGF with irinotecan, fluorouracil (FU), and leucovorin (LV; IFL) has increased survival of patients with metastatic colorectal Ca compared with IFL It appears necessary to use combination therapy in treatment and has supported the concept that the use of immunochemotherapy improves results over chemo alone. ...Read more

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How effective is the FOLFIRI-Bevacizumab chemotherapy regimen for treating colon cancer?

How effective is the FOLFIRI-Bevacizumab chemotherapy regimen for treating colon cancer?

Moderately useful: FOLFIRI-Bev is the standard, commonly used first line chemotherapy for metastatic Colon cancer. It can add about 12 to 18 months extra to your life such that an average patient can live for 2 to 3 years(some live upto 5-6 years... depending on sites of metastases and their response to chemotherapy. You need tell us more about your history such as dates of diagnosis and treatments/results so far?? ...Read more

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How are chemotherapy and radiation therapy different?

How are chemotherapy and radiation therapy different?

X-rays versus drugs: Radiation is a beam of energy that comes from aimable machines through the air. Chemotherapy is drugs given into veins or by oral pills. So one goes through air and the other in the blood. ...Read more

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For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read more

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What are typical side effects of liver cancer chemo therapy consisting of Gemcitabine + Oxaliplatin ( GEMOX) ?

Modest side effects: Gemcitabine is a well tolerated chemo drug. It can cause some decrease in blood counts, so monitor your CBC periodically(something your oncologist will discuss and do it for you). Oxaliplatin has some additional side Effects like nausea and neuropathy, yet these are manageable by any good oncologist. So I would advice you to proceed with chemo and wait to worry if you have any side effects. ...Read more

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Are the drugs faslodex (fulvestrant) and Xeloda similiar?

Are the drugs faslodex (fulvestrant) and Xeloda similiar?

NO: Faslodex (fulvestrant) - is hormone therapy for metastatic breast cancer, it`s given as an injection. Xeloda - is an oral chemotherapy drug that can also be used in metastatic breast cancer as well as in other cancers. ...Read more

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How effective is the TAC chemotherapy regimen for treating breast cancer?

How effective is the TAC chemotherapy regimen for treating breast cancer?

Very!: TAC stands for Taxotere, Adriamycin, (doxorubicin) and Cyclophosphamide. It is one of the strongest regimens for treating breast cancer, and some would say too strong. Depending on the type of breast cancer you have, or the stage, you might be able to receive a gentler regimen. If you want to know more, get a second opinion. ...Read more

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How effective is the FOLFIRI chemotherapy regimen for treating colon cancer?

How effective is the FOLFIRI chemotherapy regimen for treating colon cancer?

Some effect: Single drug chemotherapy has failed to produce significant improvement in colorectal Ca. Combination chemo as in FOLFIRI with irinotecan has added about 5 month prolongation in survival and with immunotherapy using Avastin (bevacizumab) or Erbitux an additional 2-3 months can be observed. Chemo-Immuno with a mAb targeting the immunogenic protein appears to be giving further enhancement. ...Read more

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Can children and teenagers take Temodar (temozolomide)?

Can children and teenagers take Temodar (temozolomide)?

Depends: Temodar (temozolomide) is indicated in adults in certain blood cancers. FDA recommendations often reflect what the drug company submitted during research. In Pediatrics, we often use medication OFF LABEL - meaning it's not listed as approved for children. However, many private research helps us determine if pediatric uses are helpful. Discuss your concerns with your specialist. http://www.drugs.com/pro/temodar.html ...Read more

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Can you have surgery while taking Avastin (bevacizumab)?

Can you have surgery while taking Avastin (bevacizumab)?

Avoid it, if it is p: Avastin (bevacizumab) causes interference in wound healing. So it is best to stop Avastin (bevacizumab) if you need to undergo surgery. It takes 4 to 6 weeks for the Avastin (bevacizumab) effects to go away after the last dose used.. Then it is safer to do surgery. Your oncologist as well as your surgeon can/will guide you in this regard, if you have not already been told about it. ...Read more

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What affect does avastin (bevacizumab) have on fertility?

What affect does avastin (bevacizumab) have on fertility?

Possible menopause: Avastin (bevacizumab) is used to treat certain advanced cancers. It may cause ovarian failure (induced menopause), up to 34 percent of women in one study. However, this will reverse in 1/5 of women once Avastin is stopped. ...Read more

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I need some information about the mechanism of avastin (bevacizumab) on the body..

I need some information about the mechanism of avastin (bevacizumab) on the body..

Stops angiogenesis : Avastin (bevacizumab), and was the first commercially available angiogenesis inhibitor. Its main action is the inhibition of the function of a natural protein called vascular endothelial growth factor (vegf) that stimulates new blood vessel formation. Because most malignant tumors are highly dependant on angiogenesis to obtain a blood supply and nutrients Avastin can stop or delay growth. ...Read more

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What is the success of avastin (bevacizumab) for treating glioblastoma? Does it work?

What is the success of avastin (bevacizumab) for treating glioblastoma? Does it work?

Marginal: It is primarily being used to treat recurrent malignant gliomas . The latest results with its use as a frontline treatment for malignant glioma show no real benefit over the current conventional regimen using radiation therapy and chemotherapy with temodar (temozolomide). ...Read more

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Do you know the side effects of taking temodar (temozolomide) for longer than two years?

Side effects: I am not aware of any possible side effects Of Temodar (temozolomide) except rarely , it may increase susceptibility to another kind of cancer. ...Read more

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My sister was diagnosed with atypical meningiomanow taking avastin (bevacizumab) what is her survival rate ?

My sister was diagnosed with atypical meningiomanow taking avastin (bevacizumab) what is her survival rate ?

Good: Meningiomas are usually benign tumors with excellent prognosis. Symptoms depends on the location of tumor. Atypical meningioma is more concerning and it is in a spectrum ( worse than benign but better than malignant meningioma). The idea is to see the rate of growth, slow it if possible. If progressing, surgery, radiosurgery, or traditional radiation or combination of above are possible options. ...Read more

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How long is a woman usually on cytozen and avastin (bevacizumab) ?

How long is a woman usually on cytozen and avastin (bevacizumab) ?

Medication use: Avastin (bevacizumab) is a biologic used to interfere with new blood vessel growth in various tumors. It is not time-limited or sex-limited to females. The other drug is an Ayurvedic medicine and I can't comment on its use. ...Read more

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Can pregnant women take Temodar (temozolomide)?

Can pregnant women take Temodar (temozolomide)?

Temodar (temozolomide): is FDA Pregnancy Category D - is not recommended. ...Read more

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Does avastin (bevacizumab) reduce male fertility?

Does avastin (bevacizumab) reduce male fertility?

No (so far): Avastin (bevacizumab) is a monoclonal antibody that inhibits blood vessel growth. It can impair fertility in women, but i don't find any studies that show reduction in male fertility. For the fda prescribing information with all side effects, go here: http://www.Gene.Com/gene/products/information/pdf/avastin-prescribing.Pdf. ...Read more

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How does avastin (bevacizumab) affect male fertility?

How does avastin (bevacizumab) affect male fertility?

It doesn't (so far): Avastin (bevacizumab) is a monoclonal antibody that inhibits blood vessel growth. It can impair fertility in women, but i don't find any studies that show reduction in male fertility. For the fda prescribing information with all side effects, go here: http://www.Gene.Com/gene/products/information/pdf/avastin-prescribing.Pdf. ...Read more

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Do you know are avastin (bevacizumab) and Xeloda the same?

Do you know are avastin (bevacizumab) and Xeloda the same?

Different: Xeloda is oral chemotherapy while Avastin (bevacizumab) is a monoclonal antibody targeting vascular growth factor. Bevacizumab (avastin) is a recombinant humanized monoclonal antibody that blocks angiogenesis by inhibiting vascular endothelial growth factor. It also helps with chemo by allowing entry into tumor microvascular structures while Xeloda helps to inhibit DNA synthesis ...Read more

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Which is more effective: Avastin (bevacizumab) or Erbitux?

Identical: Data on Bevacizumab or Erbitux in patients with metastatic colorectal cancer, patients who do not have a KRAS 12/13 gene mutation, have nearly identical survival rates. These identical results were seen after chemotherapy, where survival with chemo alone was about 5 months vs. 7-8 months using either bevacizumab (Avastin) or cetuximab (Erbitux). ...Read more

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Can avastin (bevacizumab) cause an increase of tumor markers?

Can avastin (bevacizumab) cause an increase of tumor markers?

Bevasizumab or: Avastin (bevacizumab) vies with vascular endothelial growth factor. It's action interferes with development or growth of blood vessels needed by tumors. Causes incresed blood pressure and bleeding as leading toxicity. No obvious reason that it should influence tumor markers. ...Read more

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What effect does avastin (bevacizumab) have on male fertility?

What effect does avastin (bevacizumab) have on male fertility?

Unsure: Avastin (bevacizumab) has shown to be deterimental to female reporuductive potential with up to 30-35% have serious complications (ovarian failure). To my knowledge there are no studies on men. Any chemotherapy has the potential risk of causing fertility issues in the future. You may want to consider freezing sperm with a sperm bank or your local reproductive endocrinologist. Also talk to your oncologist. ...Read more