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Doctor insights on: Autosomal Adrenoleukodystrophy

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What is adrenoleukodystrophy?

What is adrenoleukodystrophy?

Not a good disorder: Adrenoleukodystrophy describes several closely related inherited disorders that disrupt the breakdown of very long chain fatty acids (vlcfa). These vlcfa then accumulate in the nervous system, especially the brain, and the adrenal glands and disrupt their function. The childhood form is progressive and there is no specific treatment available yet. ...Read more

Dr. Harry Chugani
45 doctors shared insights

Adrenoleukodystrophy (Definition)

Adrenoleukodystrophy is a term for a set of rare, inherited conditions where a decreased ability to breakdown some types of fat leads to brain damage, weak muscles, adrenal gland ...Read more


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What is adrenoleukodystrophy?

What is  adrenoleukodystrophy?

Abnormal fatty acids: It is a spectrum of disorders that include adrenal insufficiency along with an abnormal deposition of fatty acids in nerve tissues including the brain. It ranges from mild to fatal. ...Read more

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How common is adrenoleukodystrophy?

Adrenoleukodystrophy: Adrenoleukodystrophy is passed down from parents to their children as an x-linked genetic trait. It therefore affects mostly males, although some women who are carriers can have milder forms of the disease. It affects approximately 1 in 20, 000 people from all races. The condition results in the buildup of very-long-chain fatty acids in the nervous system, adrenal gland, and testes, which disrupts. ...Read more

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Can adrenoleukodystrophy be treated?

No real cure: Unfortunately, much of what can be done is symptomatic relief, such as adrenal support and perhaps hormonal treatment for testicular dysfnctn. It has been said that lorenzo's oil is of value, but little proof of success. Contact a major medical school, as research projects may result in a few breakthroughs. ...Read more

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What are the tests for adrenoleukodystrophy?

Tests: Tests by a neurologist can include: vision screening, MRI of the brain, blood tests for (vlcfa) very long-chain fatty acids, genetic testing and skin biopsy. ...Read more

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What sort of problem is adrenoleukodystrophy?

Adrenoleukodystrophy: Adrenoleukodystrophy is passed from parents to their children as an x-linked genetic trait. It affects males, although some women who are carriers can have mild disease. It affects 1 in 20, 000. The condition results in the buildup of very-long-chain fatty acids in nervous system, adrenal gland, and testes, which disturbs normal function. For more see: http://www.Umm.Edu/ency/article/001182.Htm. ...Read more

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What are the symptoms of adrenoleukodystrophy?

Depends on type: The symptoms depend on the type of adrenoluekodystrophy. This site is very educational: http://www.Adrenoleukodystrophy.Net/. ...Read more

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Does anyone know about adrenoleukodystrophy diease?

Complex illness: This is an x-linked recessive disease mostly in young males, but can be seen later in life, due to accumulation of long-chain fatty acids. Causes loss of behavioural control, even hyperactivity, but can lose ability to walk, have adrenal and sexual failure. Predominant damage to central nervous myelin (nerve insulation). Hard to diagnose due to varied presentation. No cure. Lorenzo's oil? ...Read more

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What percentage of the us population have adrenoleukodystrophy?

1 in 20,000: From the ncbi: http://www.Ncbi.Nlm.Nih.Gov/pubmedhealth/pmh0002165/ adrenoleukodystrophy (ALD) affects approximately 1 in 20, 000 people in the usa. Given a total population of 311, 591, 917 (www.Google.Com/publicdata), this means approx. 15, 580 people have ALD or 0.005%. ...Read more

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I was wondering is adrenoleukodystrophy fatal?

Unfortunately YES: It is unusual for these unfortunate children to live through adolescence. ...Read more