Doctor insights on:
Autoimmune Small Fiber Neuropathy
Definitions: Small fibers which mediate pin and temperature sensations lack myelin, and are indeed pure axons, so the terms small fibre neuropathy or axonopathy are synonymous. Polyneuropathy usually refers to a larger fibre process which is distal bilateral and symmetrical, and can be either axonal or schwann cell predominant, and affects strength, balance, proprioception, and light touch. ...Read moreSee 2 more doctor answers
A complete nerve transection will leave an area totally numb. The distribution of the numbers depends upon where the nerve was cut. A partial nerve injury may leave the area tingly or incompletely numb. Finally even if the nerve is not cut the swelling and bruising to the tea can affect the nerve as well. Usually we consider sharp penetrating injuries as likely having nerve lacerations when sensation is lost. A hand surgeon can examine the hand and pinpoint the site or extent of nerve injury and recommend ...Read more
Possibly: The prevalence of neuropathy among patients with celiac disease is much higher than in healthy people. Sometimes, the neurological problems arise from nutritional deficiencies due to malabsorption. However, some cases are due to autoimmunity and associated with the underlying disease (Celiac). ...Read more
↑glucose most common: basis neuropathy; Google: "peripheral neuropathy etiology", yet many other associations exist, note word association; Why? Data about associations; mechanisms not fully understood. Cholesterol is part of every animal cell, enables cell membrane flexibility & has never been correct issue despite promotioin by NIH.gov as surrogate for Lipoproteins. Hi odds stress/anger/fear an issue; more complex. ...Read more
DEFINITIONS: Peripheral neuropathy is generic term for abnormal nerves in limbs. Many of these involve large fibers which can cause weakness, numbness, imbalance. The small fiber neuropathy presents with pain, decrease in pin and temperature sensation and caused by a limited number of conditions. Both large and small fibres may be involved in peripheral nerve disorder. ...Read moreSee 1 more doctor answer
Maybe in part: We are increasingly learning that small fibre neuropathies are common, especially associated with diabetes, but also present even in some fibromyalgia cases. A medical food metanx, may result in increased nerve fiber density in the skin after 6-12 months. If the cause is due to an immune polyneuritis, ivig can reverse much of it. Need to understand causation to treat successfully. ...Read more
Peripheral neuropath: Small fiber neuropathy is a peripheral neuropathy that occurs from damage to small unmyelinated nerve fibers present in skin, peripheral nerves, and organs.The role of these nerves is to innervate the skin (somatic fibers) and help control autonomic function (autonomic fibers). It is estimated that 15-20 million people in the USA have some form of peripheral neuropathy. ...Read more
Can a gluten allergy cause small fiber neuropathy to worsen or cause small fiber neuropathy as an underlying cause?
Likely yes but...: Eating gluten is associated with increased zonulin proteins in the gut. This does not depend on gluten allergy or celiac conditions. Increased zonulins is associated with increased inflammation throughout the body. The small fibers are located within fascia, and may theoretically be injured by this inflammation. www.blatmanhealthandwellness.com ...Read moreSee 1 more doctor answer
Yes: In some cases, marked benefits occur with infusions of ivig, and we know that diabetics who take metanx experience fibre re-growth and multiplication after about 9-12 months. If problem due to treatable condition such as celiac disease or sarcoid, might also see reversal. Uncover the precise mechanism of the disorder, and treat appropriately. ...Read more
I have small fiber neuropathy with possible ischemic neuropathy. They believe its an autoimmune response. Detected by skin bx. Is this fatal . ? Ivig
Sure: First, work closely with your doctor to develop a gluten free diet and control gastro-intestinal symptoms. Secondly, start a medical food, MetanX or a generic equivalent and take twice daily. Will help regrow small fibres over 9-10 months, and should result in less symptoms in feet and legs. Pain can be controlled by Lyrica (pregabalin) or Cymbalta. ...Read more
I have small fiber neuropathy 2nd skin biopsy shows IgM deposits in vessels. Also says microvascular injury syndrome. Is this autoimmune process?
May be very complex: Small fibre neuropathy can be encountered with celiac disease, diabetes, pernicious anemia, fibromyalgia, alcohol/nutritional issues, occult neoplastic processes (as mentioned), a variety of "paraproteinemias", lupus and sjogren's disease, some of which will have immune deposits involved. Most of these situations are immune mediated and may respond to ivig. ?Visit local medical school for advice? ...Read moreSee 1 more doctor answer
Emg study of feet reads a fairly symmetric mild sensorimotor peripheral neuropathy with primarily axonal loss features. liver, sugar clean.Thoughts?
Dx with small fiber neuropathy with mild deposits of c5b-9 within vessels also microvascular injury syndrome. I have pots. Is this autoimmune or deadl?
Depends on cause: Do you indeed possess biopsy proven small fibre neuropathy, and have blood and urine studies been completed to uncover causation? (gastroparesis and small fibre issues can be seen in diabetes for example.) sometimes, an increase in fiber consumption will help. Although the medical food metanx may help peripheral nerves, not clear if it affects gastroparesis, but worthwhile trying. ...Read more
The immune system developed to tell our own, normal cells (self) from foreign and abnormal cells (non-self). This lets the immune system eliminate viruses, bacteria, fungi and cancer cells from our body without harming normal cells. Sometimes the immune system fails to tell self from non-self and it attacks normal cells, for example in ...Read more
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