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Doctor insights on: Autoimmune Pemphigus

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What is the autoimmune disorder pemphigus vulgaris?

What is the autoimmune disorder pemphigus vulgaris?

Pemphigus: Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes.The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, . ...Read more

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Autoimmune (Definition)

The immune system developed to tell our own, normal cells (self) from foreign and abnormal cells (non-self). This lets the immune system eliminate viruses, bacteria, fungi and cancer cells from our body without harming normal cells. Sometimes the immune system fails to tell self from non-self and it attacks normal cells, for example in ...Read more


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Pemphigus vulgaris is an autoimmune disorder in humans in which antibodies are produced against the cadherins, is this true?

Pemphigus vulgaris is an autoimmune disorder in humans in which antibodies are produced against the cadherins, is this true?

Test question?: Basically yes, though the cadherins are the principal targets in pemphigus foleaceus, which is common in Central America, and desmogleins in the more familiar forms we see here in the US http://www.ncbi.nlm.nih.gov/pubmed/23725016 ...Read more

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What is the permanent cure for the auto immune skin disease called pemphigus ?

Pemphigus: There are multiple immunosuppressive treatments available for the management of pemphigus. Typically treatment begins with oral steroids but commonly Dapsone or intravenous immunoglobulins are also used. Unfortunately, many autoimmune diseases must be treated by trial and error methods to find the most effective medication. ...Read more

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What are the tests for pemphigus?

Biopsy: The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist. ...Read more

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Is pemphigus curable?

Is pemphigus curable?

Not yet: There is not yet a cure for pemphigus vulgaris, but the condition is controllable with immunosuppressive treatment. The usual treatment is with corticosteroids, which are often started at high doses, together with immunosuppressive drugs (azathioprine, cyclophosphamide, cyclosporin, methotrexate, etc.). New medicines called biologics (such as rituximab) are being studied, for treating pemphigus. ...Read more

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Can pemphigus be contagious?

Can pemphigus be contagious?

Pemphigus: Pemphigus is an autoimmune disease and is not contagious. Autoimmune diseases may run in families so it could be possible for 2 members of the same family to develop the same problem. ...Read more

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What is the treatment for pemphigus?

What is the treatment for pemphigus?

No one best medicine: Prednisone is the drug most commonly used to treat pemphigus. Other immunosuppressive agents are used either with or instead of Prednisone depending upon the individual's response & tolerance. All of these medications have potentially significant adverse effects so management by an expert in this disease and in using these drugs is vitally important. What's best for one is not best for another. ...Read more

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What is pemphigus?

Blisters: This is a cruel disease in which the patient makes antibodies against a protein that holds the skin cells together. This is one of the most serious diseases in dermatology practice, and calls for a lasting relationship with one who you trust. Appearing suddenly, it may warn of a cancer deep in the body. Good luck. ...Read more

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What causes pemphigus?

What causes pemphigus?

Autoimmune antibody: A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus. ...Read more

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Dr. Lindsay Strowd
131 doctors shared insights

Pemphigus (Definition)

Pemphigus is a group of rare autoimmune skin conditions characterized by blistering lesions in the skin and mucosal membranes such ...Read more