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Doctor insights on: Autoimmune Pemphigus

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What is the autoimmune disorder pemphigus vulgaris?

What is the autoimmune disorder pemphigus vulgaris?

Pemphigus: Pemphigus vulgaris is an autoimmune disorder that involves blistering and sores (erosions) of the skin and mucus membranes.The immune system produces antibodies against specific proteins in the skin and mucus membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, . ...Read more

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Autoimmune (Definition)

The immune system developed to tell our own, normal cells (self) from foreign and abnormal cells (non-self). This lets the immune system eliminate viruses, bacteria, fungi and cancer cells from our body without harming normal cells. Sometimes the immune system fails to tell self from non-self and it attacks normal cells, for example in ...Read more


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Pemphigus vulgaris is an autoimmune disorder in humans in which antibodies are produced against the cadherins, is this true?

Pemphigus vulgaris is an autoimmune disorder in humans in which antibodies are produced against the cadherins, is this true?

Test question?: Basically yes, though the cadherins are the principal targets in pemphigus foleaceus, which is common in Central America, and desmogleins in the more familiar forms we see here in the US http://www.ncbi.nlm.nih.gov/pubmed/23725016 ...Read more

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What is the permanent cure for the auto immune skin disease called pemphigus ?

Pemphigus: There are multiple immunosuppressive treatments available for the management of pemphigus. Typically treatment begins with oral steroids but commonly Dapsone or intravenous immunoglobulins are also used. Unfortunately, many autoimmune diseases must be treated by trial and error methods to find the most effective medication. ...Read more

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What causes pemphigus?

What causes pemphigus?

Autoimmune antibody: A glycoprotein the binds skin cells (keratinocytes) together is the reported target of auto-immune antibodies in pemphigus. ...Read more

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What are the tests for pemphigus?

What are the tests for pemphigus?

Biopsy: The diagnosis of pemphigus is made by history and examination of characteristic lesions on the skin or in the mouth and throat. A definitive diagnosis is made by biopsy with examination of the tissue by a dermatopathologist. ...Read more

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What are the most common symptoms of pemphigus?

Pemphigus: Severe autoimmune disease where your antibodies attack the dermis and epidermis cells (aka skin). You need to see a dermatologist about this asap. Risks include infection, dehydration, and ultimately death if not treated appropriately. ...Read more

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Can pemphigus be contagious?

Can pemphigus be contagious?

Pemphigus: Pemphigus is an autoimmune disease and is not contagious. Autoimmune diseases may run in families so it could be possible for 2 members of the same family to develop the same problem. ...Read more

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What is pemphigus vulgaris?

What is pemphigus vulgaris?

An immune skin Dx.: It is an autoimmune skin disease with many new treatment options. ...Read more

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What is the cause of pemphigus vulgaris ?

Unknown: P.V. Is an autoimmune disease in which antibodies have been formed to proteins that bind skin cells together. As a result, bonds between cells are easily disrupted; a clinical finding referred to a nikolsky's sign in which skin blisters can be created by rubbing the skin. P.V. Typically causes skin and mucous membrane sores. Treatment typically begins with oral steroids and other immunosuppresants. ...Read more

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Dr. Lindsay Strowd
129 doctors shared insights

Pemphigus (Definition)

Pemphigus is a group of rare autoimmune skin conditions characterized by blistering lesions in the skin and mucosal membranes such ...Read more