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Doctor insights on: Autoimmune Diseases With Morning Stiffness But No Swelling

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What rheumatic diseases cause edema (in legs and arms) and widespread swelling with joint pain? I have diagnosis of seronegative spondlyoarthritis.

What rheumatic diseases cause edema (in legs and arms) and widespread swelling with joint pain?  I have diagnosis of seronegative spondlyoarthritis.

None. See yur doctor: None of the rheumatic diseases directly cause swelling in the hands & legs. This is more likely a side effect of medications (especially steroids & DMARDs like Enbrel) or a separate problem of the liver (cirrhosis), kidney (nephropathy), or heart (heart failure). There are autoimmune causes of cirrhosis & nephropathy. In this forum, it is hard to say if they are related to seroneg spondylarthritis ...Read more

Dr. Tracy Lovell
503 doctors shared insights

Autoimmune Disease (Definition)

In auto immune disease the enemy is from with in . As name implies "auto" is self and "immune " is immune system . One 's own immune system for unknown reason turns against self and destroys or damages tissues or cells . List of auto immune disease are many and growing . End result is destruction of of tissues such as thyroid , pancreas or cells such as white ...Read more


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Morning stiffness and swelling both wrists for several hours. Redness, pain, warmth in several joints, worse with activity. blood work negative. Ra?

Morning stiffness and swelling both wrists for several hours. Redness, pain, warmth in several joints, worse with activity. blood work negative. Ra?

Arthritis. 3 options: Osteoarthritis: blood work negative, possible family members with similar findings Autoimmune arthritis: Rheumatoid, psoriatic or other. Blood work frequently negative. Infectious/crystal-induced arthritis: Lyme disease, viral infection, syphilis, gout, pseudogout. See a rheumatologist who will sort these options out for you. ...Read more

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Slightly swollen wrist with pain and hand pain. No injury. Common with Lupus? Is this arthritis?

Slightly swollen wrist with pain and hand pain.  No injury. Common with Lupus?  Is this arthritis?

Potentially: Patients with lupus can have an associated inflammatory arthritis that can cause pain and swelling in various joints. The hands and wrists can definitely be involved. Don't hesitate to let your doctor know this is occurring and there may be medicine that can help. ...Read more

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Is morning stiffness more asociated with joints or muscles or tendons?And morning stiffness doesn't have to be seen swollen? Just pain n les rangemotin

Is morning stiffness more asociated with joints or muscles or tendons?And morning stiffness doesn't have to be seen swollen? Just pain n les rangemotin

Joints: You feel stiff because you cannot move the joint very easily. Tendons attached to the joints , so yes they can be theoretically be affected. But no structural injury to them. Muscle stiffness is usually associated with vigorous exercise to physical work. ...Read more

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Does visible swelling in the fingers always accompany rheumatoid arthritis?

Does visible swelling in the fingers always accompany rheumatoid arthritis?

Most people with RA: Joint swelling of the fingers is seen early in the course of RA in the majority of patients. The knuckles are tender to the touch and there is soft tissue swelling around the knuckles causing limited motion and stiffness. This can progess to puffy swelling of the whole hand. Warm compresses and simple hand exercises can reduce swelling. Isotoner gloves worn overnight reduce swelling. ...Read more

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In my late 30s with SLE with secondary sjogrens syndrome.Had symptoms for years.I have no organ involvement. Is the likelihood of this very minimal?

In my late 30s with SLE with secondary sjogrens syndrome.Had symptoms for years.I have no organ involvement. Is the likelihood of this very minimal?

Prognosis of: both lupus and Sjogrens is unpredictable. If your condition is stable and well-controlled, it should continue that way indefinitely. Ask you rheumatologist for more specific advice, because there is tremendous case by case variation. ...Read more

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Can sjogren's syndrome cause tightness in joints with no swelling and only mild moving joint pain?I have full range of joints but just feel tight.

Can sjogren's syndrome cause tightness in joints with no swelling and only mild moving joint pain?I have full range of joints but just feel tight.

Normal: Sjogrens causes abnormal secretions from lacrimal and salivary glands causing dry eyes, and dry mouth. Know of no effect on joint lubrication, pain, motion, or stability. ...Read more

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Is there always swelling with enthesitis?

Is there always swelling with enthesitis?

Yes, swollen : Enthesitis or enthesiopathy is inflammation where tendons or ligaments insert into the bone. Recurring stress or inflammatory autoimmune disease can cause inflammation or occasionally fibrosis and calcification. One common site is at the heel, particularly the achilles tendon.It is associated with hla b27 arthropathies like ankylosing spondylitis, psoriatic arthritis, and reactive arthritis. ...Read more

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Could fibromyalgia cause same symptoms as osteoarthritis in my knees.I have no swelling but some pain.?

Could fibromyalgia cause same symptoms as osteoarthritis in my knees.I have no swelling but some pain.?

Observe closely: Fibromyalgia classically affects soft tissue pain messengers (ligaments, muscles, skin, even blood vessels). Osteoarthritis affects bone. Because the knee is a complex structure comprised of both bone & soft tissue, it may be hard to distinguish. But do you have fibromyalgia--pain on both sides of the body and above & below the waist? ...Read more

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Does rheumatoid arthritis always cause visible swelling in the hands?

Does rheumatoid arthritis always cause visible swelling in the hands?

No: While rheumatoid arthritis often affects the hands and feet it is not uniform. So people never get hand disease. For som hand join or tendon swelling is the presenting symptoms. ...Read more

Dr. John Chiu Dr. Chiu
2 doctors agreed:
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Can nerve conditions mimic lupus symptoms? I have high ANA but no other positive lupus test. Severe muscle pain and all over itchiness for 1 year.

Dr. John Chiu Dr. Chiu
2 doctors agreed:
Can nerve conditions mimic lupus symptoms? I have high ANA but no other positive lupus test. Severe muscle pain and all over itchiness for 1 year.

See derm: Lupus can involve the CNS but you would be expected to have other organ involvement as well. Lups is not associated with itching and thus a dermatology consult may be worthwhile. I presume you have already consulted a rheumatologist. ...Read more

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Why might joint swelling occur with rheumatic fever?

Why might joint swelling occur with rheumatic fever?

Immune response: Rheumatic fever, a streptococcal infection causes the body to be "tricked" into producing an immune response to the body, in other words there is a cross reactivity of immune defenses whereby the cells responsible for immunity start to attack the body itself, and in this case major joints that result in what we call arthritis. It is nothing to take lightly and must be fought with antibiotics. ...Read more

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If not lupus or r.A., what could cause joint swelling and pain, stiffness, and fatigue?

If not lupus or r.A., what could cause joint swelling and pain, stiffness, and fatigue?

Seronegative : Seronegative spondyloarthropathies are joint diseases which affect the spine and peripheral joints that are negative for rheumatoid factor. There are several of these including reactive arthritis and psoriatic arthritis. A rheumatologist can sort out which one and get you appropriate treatment. ...Read more

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Sudden onset acute polyarticular arthritis. Mild thrombocytopenia. Substantial swelling at knees, but also small joints hands feet. Mild fever, malaise, no skin invlmt. Happens every 10 yrs > hospital?

Sudden onset acute polyarticular arthritis. Mild thrombocytopenia. Substantial swelling at knees, but also small joints hands feet. Mild fever, malaise, no skin invlmt. Happens every 10 yrs > hospital?

Outpatient.: If this is recurrent we already have some insight into what it is or at least what it has not been in the past. Don't see any reason for the hospital but sounds like you would benefit from rheumatology involvement and perhaps some routine lab studies. ...Read more

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Autoimmune (Definition)

The immune system developed to tell our own, normal cells (self) from foreign and abnormal cells (non-self). This lets the immune system eliminate viruses, bacteria, fungi and cancer cells from our body without harming normal cells. Sometimes the immune system fails to tell self from non-self and it attacks normal cells, for example in ...Read more


Dr. David Schleimer
1,498 doctors shared insights

Swelling (Definition)

Swelling is the enlargement of organs, skin, or other body parts. It is caused by a buildup of fluid in the tissues. The extra fluid can lead to a rapid increase in weight over a short period of time (days to weeks). Swelling can occur all over the body (generalized) or only in one part ...Read more