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Doctor insights on: Autoimmune Biliary Cirrhosis

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Liver diagnosis 60 f -ast302/alt438 ANA pos. Us neg liver biopsy 1st dr diagnosis pri biliary cirrhosis. 2nd dr autoimmune hep. diangosis ursodiol 5wk retest. Do you agree?

Liver diagnosis 60 f -ast302/alt438 ANA pos. Us neg liver biopsy 1st dr diagnosis pri biliary cirrhosis. 2nd dr autoimmune hep. diangosis ursodiol 5wk retest. Do you agree?

Yes, need follow up: You have a combination of primary biliary cirrhosis (pbc) and autoimmune hepatitis (aih). The treatments are different, ursodeoxycholic acid is used to treat pbc, but may not bring down the ast/alt elevation associated with aih. If the urso does not bring down the ast/alt, you may need additional medications, such as steroids or azathioprine, to control the aih. ...Read more

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Autoimmune (Definition)

The immune system developed to tell our own, normal cells (self) from foreign and abnormal cells (non-self). This lets the immune system eliminate viruses, bacteria, fungi and cancer cells from our body without harming normal cells. Sometimes the immune system fails to tell self from non-self and it attacks normal cells, for example in ...Read more


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What are the tests for biliary cirrhosis?

What are the tests for biliary cirrhosis?

Autoantibody &Biopsy: In addition to abnormal blood tests due to malfunction of liver, patients with primary biliary cirrhosis have peculiar autoantibodies, anti-mitochondrial antibodies. Blood tests and imaging suggest cirrhosis, confirmation requires biopsy (usually needle biopsy) and examination of the tissue by a pathologist. ...Read more

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What are the symptoms of biliary cirrhosis?

Jaundice & itching: Primary biliary cirrhosis is an autoimmune phenomenon and may be associated with damage to other organs. The prominent symptoms of biliary cirrhosis are jaundice and itching. With progression symptoms of liver failure, e.g., edema, bleeding, ascites etc appear. ...Read more

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Describe the features of biliary cirrhosis.?

Describe the features of biliary cirrhosis.?

Liver failure: There are many things that happen with cirrhosis, depending on how severe it is. These include confusion, bleeding from the GI tract, jaundice, fluid buildup in the belly, increased risk for liver cancer, and other symptoms. ...Read more

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What happens when you have biliary cirrhosis?

Liver failure: Biliary cirrhosis causes progressive damage to the liver. There is fibrosis (hardening) of the substance of the liver, increasing pressure in the blood supply, and slowly damaging the cells. Sepending on the cause of cirrhosis, there is very little that will cause reversal of the damage. ...Read more

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I've got biliary cirrhosis. What consequences should I be looking for?

I've got biliary cirrhosis. What consequences should I be looking for?

Liver problems: With primary biliary cirrhosis the small bile ducts in the liver are affected. As time goes on cirrhosis of the liver can result. This results in jaundice and itching. As cirrhosis worsens people have issues with enlarged veins around the esophagus, stomach and rectum. These can cause severe bleeding. Also complete liver failure can result. ...Read more

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What are early signs & symptoms of primary biliary cirrhosis?

None: Early on primary biliary cirrhosis can be associated with little or no symptoms at all, just like many chronic liver diseases. As the disease progresses, however, many people start experiencing chronic fatigue & weakness, jaundice and itching (from bilirubin build up in skin), followed by complications of cirrhosis such as ascites & malnutrition. ...Read more

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What type of diet should an infant with biliary cirrhosis be given?

What type of diet should an infant with biliary cirrhosis be given?

Ask your: Neonatologist. If you have cirrhosis - keeping the child away from liver matebolized toxins would be helpful. ...Read more

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Why do the sufferers of primary biliary-cirrhosis feel so tired all the time?

PBC = inflammation: Primary biliary cirrhosis is an autoimmune inflammatory disease, manifest by low but persistent liver damage. This causes a variety of biochemical changes which manifest by fatigue. Not all patients have fatigue, many patients are asymptomatic until the disease is advanced. Cirrhosis is also associated with fatigue. ...Read more

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How common are kayser fliescher rings in cholestasis and primary biliary cirrhosis, I have them, is it just as likely those two things as Wilson's?

Whoa: You cannot self-diagnose Kayser-Fleischer rings. Several percent of young folks have arcus lipoides, and there are other things that mimic it. They're specific for Wilson's and usually show up late, the person being quite sick already. If you think you may have cholestasis, primary biliary cirrhosis, and/or Wilson's, get with a competent gastroenterologist -- the workups are tricky. ...Read more

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I need information on primary biliary cirrhosis I am a 69 year female was diagnosed in 2010. What is the best test to confirm the disease. And where would be the best place for a second opinion? What should I look for as signs of progessing in the dise

Liver biopsy: Is the gold standard, and a diagnosis cannot really be made without it, although blood tests, scans and medical history/family history can strongly suggest it. Most major medical centers. Like emory university hospitals in atlanta, have liver specialists who further sub-specialize in primary biliary cirrhosis. Increasing fatigue is most common symptom of progression, with jaundice and itching. ...Read more

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Is primary biliary cirrhosis hereditary?

Basically no: There's a pair of genes that carry the ability to develop the disease and these run in families, but it's not inherited like sickle cell, huntington's or some of the other familiar entities. http://www.medicalnewstoday.com/releases/151640.php. ...Read more

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What exactly is primary biliary cirrhosis?

What exactly is primary biliary cirrhosis?

Liver disease: Primary biliary cirrhosis is an autoimmune liver disease seen most commonly in women in the 4th to 5th decade of life. It generally presents with unexplained itching and occasionally jaundice. It is frequently found on routing screening liver tests which may show an elevated alkaline phosphotase. Though not curable it is treatable and treatment slows the progression to cirrhosis. ...Read more

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How can I treat primary biliary cirrhosis ?

Ursodiol: There is not much available to treat primary biliary cirrhosis, but ursodiol helps normalize the liver enzymes. For other therapies you should discuss with a hepatologist. ...Read more

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If you get biliary cirrhosis, how do you feel?

If you get biliary cirrhosis, how do you feel?

Depends: Some patients with biliary cirrhosis have no symptoms. Others have fatigue and other have severe itching. If you have this condition, you should see your doctor. ...Read more

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What is the cause of primary biliary cirrhosis?

Autoimmune: An autoimmune disorder in which the body attacks it's own liver. ...Read more

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Who is most likely to develop biliary cirrhosis?

Who is most likely to develop biliary cirrhosis?

PBC--who gets it: 90% of pbc patients are female. Age ranges 20-80, but typically patients are 40-60. The disease is world-wide, & affects asians, caucasians, jews, african. Family clustering is common in sisters, twins, daughters, mothers. While environmental factors can't be ignored, a strong immunogenetic background for pbc that runs in families is suggested. Early sxs: fatigue, itching before jaundice, RUQ pain. ...Read more

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Dr. Sandra Lora Cremers
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Biliary (Definition)

Biliary means anything related to the production, storage, secretion, or flow of bile, whether in the liver, bile ducts, gallbladder, ...Read more


Upper Abdomen (Definition)

Draw a transverse line through the umbilicus and the upper abdomen includes every part of the belly above this line and below the ...Read more