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Doctor insights on: Atypical Lobular Hyperplasia

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What exactly is atypical lobular hyperplasia?

What exactly is atypical lobular hyperplasia?

ALH: Atypical lobular hyperplasia (alh) is an overgrowth of the cells lining the lobules which are the sacks at the ends of the breast ducts and the cells look different from the normal lobular cells. The finding of atypia (alh or ADH (vasopressin) - atypical ductal hyperplasia) is a risk marker for future breast cancer. Depending on how the alh was found further biopsy may be needed to r/o early cancer changes. ...Read more

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Is atypical ductal hyperplasia common in women?

Is atypical ductal hyperplasia common in women?

Yes.: The presence of abnormal duct cells at the time of a breast biopsy (ADH (vasopressin)) is common. This is not a pre-cancerous condition, however, women with ADH (vasopressin) do have a 2 to 4 fold increased lifetime risk of developing breast cancer as compared to the general population. ...Read more

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Dr. Marc Yune Dr. Yune
2 doctors agreed:
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Junctional nevus with cytologic atypia concern?

Dr. Marc Yune Dr. Yune
2 doctors agreed:
Junctional nevus with cytologic atypia concern?

Yes : Depending on the degree of atypia, most surgeons recommend excision with clear margins to reduce the risk of developing skin cancer (melanoma being the most concerning). Certainly excise if moderate to severe atypia. ...Read more

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Breastduct excision fibrocystic changes,ductal hyperplasia w/o atypical,apocrine metaplasia,dilated benign ducts with thermal artifact.this means what?

Breastduct excision fibrocystic changes,ductal hyperplasia w/o atypical,apocrine metaplasia,dilated benign ducts with thermal artifact.this means what?

No cancer: All of the changes in your breast are benign and there is no cancer. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Is dysplastic nevus with moderate atypia malignancy?

Is dysplastic nevus with moderate atypia malignancy?

No: Dysplastic nevus is not cancer, but left alone these can progress to cancer. Best to have it removed, that is all the treatment necessary. ...Read more

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What percentage of atypical hyperplasia becomes breast cancer?

What percentage of atypical hyperplasia becomes breast cancer?

Small percentage: In a recent study in the annals of surgical oncology, they looked at how many surgical excisions performed for atypical hyperplasia displayed either dcis or cancer. Out of the cases that the study reviewed, only about 1% of the cases upstaged to either dcis or cancer. ...Read more

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Granulamatous lobular mastitis treatment?

Granulamatous lobular mastitis treatment?

Steroids: If proven, observation and symptomatic treatment may lead to resolution. If no improvement, steroids can be used. Typically related to tb. ...Read more

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What exactly is atypical ductal hyperplasia (adh)?

What exactly is atypical ductal hyperplasia (adh)?

Breast cancer marker: ADH (vasopressin) is an abnormal proliferation of breast duct cells that is benign but is associated with present or future breast cancer. ADH (vasopressin) is suspected on mammograms with microcalcifications and is diagnosed on needle biopsy and usually requires surgical excision. About 30% of excisions for ADH (vasopressin) will show cancer. For the other 70% of women the risk of developing breast cancer over the next 8 years is 3.7%. ...Read more

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Pathology report states: Postmenapausal Weakly-proliferative endometrium with focal glandular crowding. Focal mucinous metaplasia. Is this something t?

Pathology report states: Postmenapausal Weakly-proliferative endometrium with focal glandular crowding. Focal mucinous metaplasia. Is this something t?

Excess estrogen : This is suggestive of an increased estrogen state and maybe be a precursor to endometrial hyperplasia. alternatively it may be a component of a polyp. If you are in hormone supplements or tamoxifen you should consider stopping them. It warrants follow up with periodic re biopsy yo make sure nothing else is brewing. The good news is they didn't see any tumor. ...Read more

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What exactly is atypical intraductal hyperplasia?

What exactly is atypical intraductal hyperplasia?

Precancerous changes: In breast tissue cells from needle or open surgical biopsy. Your doctor can discuss the significance of this in light of the remainder of your family history, breast examination, mammography, and your overall health. This is not cancer, but may be a sign to be watchful and have regular physician follow-up or further evaluation regarding risk of developing breast cancer. ...Read more

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Chronic non specific cervicitis with squamous hyperplasia, squamous metaplasia + focal ciliated tubal endometrial metaplasia. Cause and treatment?

Chronic non specific cervicitis with squamous hyperplasia, squamous metaplasia + focal ciliated tubal endometrial metaplasia. Cause and treatment?

Consult you GYN MD: This may be a pap report or biopsy and you don't say which. You need to consult your treating GYN MD who performed the test for your answers. ...Read more

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What causes ductal carcinoma in situ (dcis)?

What causes ductal carcinoma in situ (dcis)?

Viral insertion: DCIS is the earliest phase of transformation to malignancy developing in the ductal system before invasion into parenchyma has occurred. It is defined on mammo by clustered microcalcification. In general the long terminal repeat of the MMTV viral genome enters the ductal cell to initiate transformation. with time the cells become aggressive and invade basement membrane helped by the EBV virus ...Read more

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What is atypical epithelial hyperplasia and hyperorthokeratosis?

What is atypical epithelial hyperplasia and hyperorthokeratosis?

Description of skin: Hyperorthokeratosis means that the surface layer of the skin is thickened (extra layers of keratin) and hyperplasia means that there is an increased growth of the cells. The adjective "atypical" means that microscopically the appearance of these cells is not quite normal, although likely they are not abnormal enough to diagnose cancer or a precancerous change. Check with your doc to follow-up. ...Read more

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Is invasive lobular carcinoma the same as invasive ductal carcinoma?

Is invasive lobular carcinoma the same  as invasive ductal carcinoma?

Different: Lobular carcinoma is less common and often does not form a lump. Please see these sites for more information. http://www.mayoclinic.com/health/invasive-lobular-carcinoma/ds01063 http://www.Mayoclinic.Com/health/breast-cancer/ds00328. ...Read more

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What does this mean?Endometrial biopsy:benign proliferative endometrium with ciliated cell metaplasia without hyperplasia or malignancy

What does this mean?Endometrial biopsy:benign proliferative endometrium with ciliated cell metaplasia without
hyperplasia or malignancy

Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or cancerous cells. It's normal and usually means you can avoid major surgery if you have bleeding. Consider hormonal management or an ablation if you have bleeding problems. Take care. ...Read more

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Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?

Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?

Can be cured: If no nodes palpable and lesion localized, RT chemo can reduce size and position site for curative resection. Partial glossectomy after initial therapy. If larger and not responsive to chemo, Ive used hight dose MTX with citrovorum factor over 12 hrs. Most effective in presence of nodal disease Basic chemo is Platinum/Taxol + RT ...Read more

Dr. Ester Kwok Dr. Kwok
13 doctors agreed:
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Mammogram with punctate pleomorphic calcifications. Is that breast cancer?

Dr. Ester Kwok Dr. Kwok
13 doctors agreed:
Mammogram with punctate pleomorphic calcifications.  Is that breast cancer?

Needs investigation: Although breast calcifications may not necessarily mean cancer, pleomorphic calcifications are suspicious. A biopsy should be done. Talk to your doctor. Pleomorphism means that something is of varying shape and characteristics. A non-cancerous or benign calcification will be read as "benign-appearing". Don't delay your biopsy. ...Read more

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What does BENIGN ENDOMETRIUM W/ ATROPHIC CHANGES & FEATURES OF GLANDULAR & STROMAL BREAKDOWN mean? NEG FOR HYPHYPERPLASIA, ATYPIA, OR MALIGNANCY.

What does BENIGN ENDOMETRIUM W/ ATROPHIC CHANGES & FEATURES OF GLANDULAR & STROMAL BREAKDOWN mean? NEG FOR HYPHYPERPLASIA, ATYPIA, OR MALIGNANCY.

Pathology 101: An endometrial biopsy is usually done to look for cancer, and the pathologist here saw no signs of cancer (malignancy/atypia) in the sample obtained. The other findings can be seen with or close to menopause (natural or induced by surgery or medications), and can be normal in many situations, but context (why the test was done) is important to be able to interpret this result uniquely for you. ...Read more

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Endometrial polyp? Simple cystic hyperplasia, endometrium. Is it cancerous?

Endometrial polyp?  Simple cystic hyperplasia, endometrium. Is it cancerous?

Assuming the polyp: Was removed and "simple cystic hyperplasia" is the final diagnosis in the pathology report, then yes, it is benign. The pathology report needs to be understood in its entirety. It is also important to follow up with your doctor regarding the need for any further workup, if necessary. ...Read more

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Is squamous cell carcinoma keratoacanthoma variant deadly?

Not really: Not necessarily. It could appear suddenly and grow rapidly. But then it will reach a certain size then it will stop growing, and then regress weeks to months later. As long as it is contained, localized in the skin- surgical resection will take care of that . However if it has metastasized ( which is not common ) -then it will give you problem. ...Read more