Doctor insights on:
Atypical Cells In Thyroid Nodule
Incomplete informat: The presence of histiocytes (a type of inflammatory cell) & expected follicular cells in thyroid is not necessarily worrisome. But it depends on your symptoms, & what prompted the biopsy / FNA to begin with. Also, did you have a radioactive iodine exam? (Called "thyroid uptake & scan")? That tells you if the follicle is "functional" or not (making hormone). A hyperfunctional nodule is more worriso ...Read more
Review with your MD: Usually, when one aspirates a thyroid cyst one may see "rare epithelioid giant cells". Most simple cysts of the thyroid are benign. However, fine needle aspirate of cystic papillary thyroid carcinoma may also show this feature and may lack diagnostic cells. So, additional information is needed to interpret the cytology report. ...Read more
Possibly: Ghe tendency for transformation of a nodule in the thyroid gland depends on whether the nodule is solitary or multiple. The latter for the most part is a goiter and rarely if ever associated with Ca of thyroid. A solitary nodule has to be examined as to being hot or cold. If hot and functional Ca essentially doesn't occur. If the solitary nodule cold, there is a 30% chance of converting to Ca. ...Read more
Thyroid nodule came back negative but cells are suspicious for hurthle cell neoplasm. What does that mean?
Surgical biopsy: Hi. Going just on what you've told us, you probably need a surgical biopsy. A Hurthle cell neoplasm can be either benign or cancer, and the cytopathology often cannot make the distinction. Therefore, to exclude or confirm cancer will require a surgical biopsy. But I don't have the data. Your doc will tell you what's needed. Good luck! ...Read more
Fnac report of thyroid nodule-colloid, individual follicular cell n folliculr cell in cluster in haemorrhagic bckground. What it indicate?
Repeated thyroid nodule biopsy cold solid 3x7cm. How could he not get enough cells with such a large nodule? Also 2.4cm cold follicularGenetic testing
Possible: May be if nodule has fluid (Cyst) may not get cells (how many times was done? More than twice is unusual). If strongly suspicious for malignancy an image guided core needle biopsy, or even removal (surgery) Discuss with your doctor, plan of treatment Do not ignore if necessary take second opinion. ...Read more
I recently had a FNA of my thyroid nodule. The results showed "benign, hyperplastic nodule with extensive Hurthle cell metaplasia". Should I worry?
Needs surgery: See your doctor. You need a referral to a surgeon. Hurtle cell can be benign or malignant. It is impossible to tell whether it is benign or cancerous on a fine needle aspiration. You need surgery to remove that side of your thyroid in order to know100% if it is one or the other. ...Read more
Thyroid nodule with rare cluster ofoverlapping enlarged cells, grooves and pale chromatin. Rebiopsy or surgery? 2.9x1.1x2.2 cm
You have a choice: The results you are sharing are benign. The cells were likely from a fna biopsy. The size of your thyroid nodule meets criteria for removal, greater than 2.5 cm. Okay to talk to your doc and your surgeon about risk/benefits of waiting a few months with repeat ultrasound versus surgery now to remove one side of your thyroid. Good luck. ...Read more
Fna on thyroid nodule shows predominately hurthle cells with follicular and colloid....34yrs old....nodule 2.7cm...hurthle cells cancer??
I have HPV strain 16 I've been treated for abnormal cervical cells. I also have 3 thyroid nodules. Could HPV be the cause of the nodules?
Doctor called that my SECOND FNA for 2.7cm thyroid nodule was FLUS AGAIN. ThyroseqV2 for SECOND time was blood/too few cells to be diagnostic What now?
A little confused?: FLUS=follicular lesion of undetermined sig. There have to be cells to make this diag. The usual thing is to redo the US/if nec FNA in a few months, dep on US. If there are cells a Thyroseq. V2 is very accurate for mutations. This sounds non-diagnostic. Make sure doc doing FNA is experienced. Likely need repeat. Ask for pathologist to reread. If 3rd FNA->path look immed to make sure adeq. New doc? ...Read more
3cm hyperechoic thyroid nodule with increased vascularity, normal TSH fnac- follicular cell with hyperplastic area. What it indicates?
Uncertain: The fna can only help if it shows cancer. But in your case it is ambiguous, so your doctor should guide you what to do next? ...What did he/she suggest as the next step? Most doctors would next recommend either surgical excision or monitor closely for some time and see if it is growing in size in which case it has to be taken out. ...Read more
3cm hypoechoic solid vascular thyroid nodule with a cluster of hurthle cells, fna benign, follow up ultrasound now shows microcalcifications. Cancer?
Not necessarily...: The fact that FNA was reported as benign, the nodule is unlikely to be malignant. Small droplets of benign colloid often mimic "microcalcificatins" of papillary tumor, hence caution is advised. I would suggest repeating the FNA, and consider also collecting samples for gene profiling studies, such as, those manufactured by Veracyte and Asuragen (Note:I have no financial/other interest.) ...Read more
Went in for followup u/s for left thyroid nodule. Came back as nothing on left but new nodule on right. Worried they got the sides mixed up. Possible?
Not likely: Ultrasound exams are performed by trained technicians and supervised by physicians on site, so a mix up is unlikely. It is, however, common for many people to have multinodular goiter, meaning many cysts on both sides of the gland. These are usually benign & require no further evaluation. If concerned, a needle biopsy can be performed. ...Read more
Variable: Thyroid nodules are variable in their growth patterns. Some can grow quickly in size, particularly if there is a cystic component to the nodule. Your doctor will usually suggest an ultrasound to follow the growth of the nodule every 6 months to one year, depending on the level of suspicion. ...Read more
Usually not: In the distant past, thyroid hormone was used to 'shrink' nodules. More recent studies with ultrasound monitoring has shown that most nodules do not shrink with thyroid hormone treatment. Because thyroid cancer is the fastest increasing cancer in women, it is important to follow most thyroid nodules with ultrasound. With hashimoto's thyroiditis, there can be false or pseudonodules. ...Read more
May need biopsy: The management of thyroid nodules depends on a number of factors. How big are they? What do they look like on ultrasound? Are they "hot" (take up radioiodine) or cold? Are they part of a multinodular goiter or hashimotos thyroiditis? The risk of a nodule being cancer is usually low, but big, solitary nodules are more worrisome. A biopsy is an easy procedure by someone trained in this. ...Read more
Several steps: 1) history and physical exam by doctor, 2) blood test to assess thyroid function. If hyperthyroid: needs treatment and usually a nuclear scan. 3) if thyroid function is normal or depressed usually a thyroid ultrasound is done 4) if nodule is solid or suspicious then fine needle aspiration. 5) if benign: follow-up - if malignant (or suggestive) refer to qualified surgeon. ...Read more
Very common problem: Thyroid nodules are very common. We do not know why they appear. They normally do not cause functional changes in the thyroid. Once they are found, thyroid labs are done and ultrasound is used to evaluate. Those over 1 cm often get biopsied with fine needle aspiration biopsy. Luckily, about 95% of nodules are benign. ...Read more
Depends on problem: 3 major categories of potential health issues caused by thyroid nodules: a) large size affecting swallowing, breathing, voice ; b) over active production of thyroid hormone (hyperthyroid) ; and c) ~5% of nodules are cancer. Methimazole and ptu (propylthiouracil) are pills that block thyroid hormone production, treating b) above. Radioactive i-131 can shrink/destroy nodule, treating a) and b). Need surgery for c). ...Read more
Complicated question: Most nodules are initially treated with a biopsy. Additional therapy, if any, will depend on the results of that biopsy and any other symptoms or signs associated with that nodule. In truth, the treatment for any thyroid nodule is very individualized and impossible to generalize further. ...Read more
Only occassionally: While almost all thyroid cancers are cold, so are most benign nodules. If the nodule is hot, it is extremely rare for it to be cancer. If it is cold and looks suspicious on an ultrasound performed or at least interpreted by a very experienced clinician, it should be biopsied to see if surgery is necessary. ...Read more
Depends on the cause: If a nodule is due to hashimoto's thyroiditis (inflammation caused by autoimmunity, where one's own immune system attacks one's proteins and tissues), then taking thyroid hormone pills can shrink it. If it's a tumor that's over-producing thyroid hormone, radioactive iodine can kill it, and make it smaller). Fluid-filled cysts can be drained with a needle, but may grow back. Cancer needs surgery. ...Read more