Doctor insights on:
Arthritis Methotrexate Nausea Headache
Are there more risks or benefits with use of weekly methotrexate as injection vs oral for arthritis or ctds. Why is oral usually prescribed?
Also called cephalalgia, is pain anywhere in the region of the head or neck, & can be a symptom of a number of conditions affecting those areas. It originates from pain-sensitive structures such as cranium, muscles, nerves, vessels, subcutaneous tissues, eyes, ears, sinuses & mucous membranes. It is non-specific symptom & can be primary such as tension ha, or secondary ...Read more
How common is it to use both methotrexate and hydroxychloroquine in treating juvenile arthritis? Is this safe? What should I know before starting?
JiA treatment: For multi-drug therapy for jia, Methotrexate is more commonly paired with biologic medication. For methotrexate, watch for mouth sores and nausea. Blood testing will be needed to check blood counts and liver tests. For treatment with plaquenil, plan to have annual eye exams. ...Read moreSee 1 more doctor answer
Absolutely not...: Low dose (10 to 25mg) weekly Methotrexate is probably the best, most effective first line medication for ra. However, if you drink alcohol (any) or have pre-existing liver disease, Methotrexate can be harmful.Your doctor will need to check your liver enzymes monthly for 3 months, then every 3 months while on Methotrexate to make sure your liver is okay. Do not take if pregnant--it can kill the baby. ...Read more
Is it better to be on 25mg methotrexate injections (53pounds) or lower dose of methotrexate along with a biological in treating juvenile arthritis?
Combo much better: Injected weekly Methotrexate is clearly a good drug for juvenile arthritis but doesn't come close the ideal combination of weekly Methotrexate (12.5-20mg) and a biologic such as enbrel, remicade, or humira.Before biologics were available, using relatively high weekly doses (25mg) was common since Methotrexate by itself rarely puts jia/jra completely into remission.The combo of both most often does. ...Read moreSee 1 more doctor answer
Works: Methotrexate has become the standard of first choice forra treatment but rarely results in remission, ie no one can tell if you have it including the doctor. The risk is extremely low, although you cannot use alcohol, and is not usually used if ther is preexisting liver disease. Most patients have to add several other disease modifying drugs to get better. ...Read more
Very safe!: Although i frequently use other agents for jia, i frequently add mtx to the therapeutic mix. Considering that the dose should be lower, i still favor the subcutaneous route rather than oral. However, I have not had serious issues with mtx and children. Make sure they get supplemental folic acid! ...Read more
Good: Usually helps within 2-4 months but rarely produces 100 % remission.Quite low risk. ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
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