Top
30
Doctor insights on: Arterial Lateral Sclerosis

Share
1

1
Is sclerosis of an arterial valve dangerous? I'm 32. I have a RBBB discovered on an EKG. Had an echo showing some sclerosis. Something to worry about?

Is sclerosis of an arterial valve dangerous? I'm 32. I have a RBBB discovered on an EKG. Had an echo showing some sclerosis. Something to worry about?

Probably not: At this time there is probably nothing to worry about (the cardiologist would have let you know if there was). I would simply adopt a healthy lifestyle of exercise, healthy eating, getting to a normal BMI. As long as the sclerosis doesn't affect the way the heart pumps blood (measured as ejection fraction) then it will not cause problems. RBBB is also pretty common and not dangerous. ...Read more

Dr. Mark Pack
1 Doctor shared a insight

Artery (Definition)

Arteries are defined as blood vessels which carry blood away from the heart (to either the body or lungs). Arteries: higher pressure, thicker walls, stretch (pulse) with each heart contraction & deliver blood to the arterioles which control the flow to individual capillaries. Veins are blood vessels which carry blood from capillaries back to the heart (body to right heart; ...Read more


2

2
I am suffering from primary lateral sclerosis, is there a treatmnet?

I am suffering from primary lateral sclerosis, is there a treatmnet?

Yes there is: Primary lateral sclerosis is a form of lou gehrig's disease, which affects the motor neuron cell, and may involve a slow chronic course. The drug Riluzole is the only product on the market so far, and has shown some potential to prevent tracheostomy. Part of the treatment involves supportive care, and prevention of infections, so work closely with a team of experienced physicians. ...Read more

3

3
Can you tell me if emg tests can be normal with primary lateral sclerosis?

Can you tell me if emg tests can be normal with primary lateral sclerosis?

Would be unlikely: If motor neuron disease exists, and could be in form of primary lateral sclerosis, there will usually be some degree of EMG pathology. A fully normal EMG would tend to rule against a diagnosis of any kind of motor neuron disease, but early on, findings might be very minimal and the test might need repetition in several months. ...Read more

4

4
What is primary lateral sclerosis?

What is primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

5

5
What are the symptoms of primary lateral sclerosis?

What are the symptoms of primary lateral sclerosis?

Variant of ALS: Als affects motor nerve cells, but varies in presentation. Diagnosis of primary lateral sclerosis is challenging, as involves upper motor neuron cells and early on, an EMG test could well be non-diagnostic, as it tests the lower cells. Since this variation involves central corticospinal cells, there is unilateral weakness of arm and/or leg without sensory loss. Later, loss of muscle bulk maybe. ...Read more

6

6
Primary lateral sclerosis only 1 side, is this normal?

Not unexpected: Not surprising but this may not stay unilateral, or this may be the ultimate outcome. Motor neuron disorders vary in expression, but require attentive followup with a neuromuscular specialist on an ongoing basis. Riluzole may be of value. ...Read more

7

7
What is the definition or description of: primary lateral sclerosis?

What is the definition or description of: primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

8

8
What is amyotrophic lateral sclerosis?

Disease of nervecell: Amyotrophic lateral sclerosis, or als, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. Als does not affect the senses (sight, smell, taste, hearing, touch). It only rarely affects bladder or bowel function, or a person's ability to think or reason. The condition slowly gets worse and cause difficulty with breathing muscles. ...Read more

9

9
What is amyotrophic lateral sclerosis (als)?  

Motor neuron disease: A disorder of misfolded proteins, attacking nerve cell bodies in spinal cord and brain. Tends to involve weakness not numbness, and can affect legs and arms with flickering of muscles, loss of muscle mass, and evenually problems with breathing and swallowing. Unfortunately, there is no cure, and it preserves awareness. Gratefully, it is relatively rare. ...Read more

10

10
Could kids get amyotrophic lateral sclerosis?

Could kids get amyotrophic lateral sclerosis?

Similar: But most childhood illnesses which affect the motor neuron, like als, are quite rare, and more hereditary in origin. A variety of such disorders cause weakness in very young children, and adolescents and seem similar in outcome. Also, polio used to affect many children but is almost unknown in usa today. ...Read more

11

11
What exactly is amyotrophic lateral sclerosis?

What exactly is amyotrophic lateral sclerosis?

Lou Gehrig's disease: Als is a disease affecting the nerve cell body, causes weakness, muscle wasting, and fasciculations or fluttering of the muscles. It can affect mobility, swallowing, and breathing. There is no known cure to date, and the prognosis is often very poor. We believe it is a disorder of "misfolded proteins", similar in some ways to alzheimer's and parkinson's, but a far rarer condition, fortunately. ...Read more

12

12
Who first discovered amyotrophic lateral sclerosis?

Who first discovered amyotrophic lateral sclerosis?

Charcot: The French Neurologist Charcot is credited with the paper describing ALS as a distinct illness ...Read more

13

13
What are the tests for amyotrophic lateral sclerosis?

Diagnosis: Since we hope to find alternative problems instead of als, we search for possible other diagnoses. The testing includes blood studies, especially for hyperthyroidism, MRI tests of the neck and spinal cord, EMG studies, and even muscle biopsies on occasion. ...Read more

14

14
What sort of problem is amyotrophic lateral sclerosis?

Lou Gehrig's: Als also known as lou gehrig's disease is a disease of nerves. It is a progressive loss of muscle strength. Initial symptoms are usually muscle weakness or cramps followed by muscle paralysis in later stages. Difficulty breathing and swallowing are common due to the muscle weakness. There is no cure but there are medications to help with symptom management. ...Read more

15

15
What are the symptoms of amyotrophic lateral sclerosis?

What are the symptoms of amyotrophic lateral sclerosis?

See below: The main symptoms of ALS are weakness. The weakness often starts with one hand and then may progress to the other. The legs will often become weak as well. The muscles begin to get thinner. This is called atrophy. There may also be exaggerated reflexes and stiffness in the muscles called spasticity. The muscles that help us speak and swallow and breath can also be weakened. ...Read more

16

16
How is amyotrophic lateral sclerosis transmitted in humans?

It is not transmitte: It is not typically a heriditary or infectious disease. No one knows the exact cause. ...Read more

17

17
What does it mean when a guy has amyotrophic lateral sclerosis?

Degenrative DO: Als is a neurologic disease where nerves in the central nervous system degenerate, leading to weakness. This can cause inability to walk or use the hands or arms, facial weakness, difficulty eating and swallowing, and respiratory difficulties, leading to infections like pneumonia. It is not a curable disease. ...Read more

18

18
What is amyotrophic lateral sclerosis (als)? Can it be treated?

Lou Gehrig's disease: Als is a disease affecting the nerve cell body, causes weakness, muscle wasting, and fasciculations or fluttering of the muscles. It can affect mobility, swallowing, and breathing. There is no known cure to date, and the prognosis is often very poor. We believe it is a disorder of "misfolded proteins", similar in some ways to alzheimer's and parkinson's, but a far rarer condition, fortunately. ...Read more

19

19
What are the challenges of living with amyotrophic lateral sclerosis?

Very difficult: ALS is a progressive nasty disease with NO cure or even significant control other than Riluzole, and causes muscular atrophy, weakness, fasciculations, and eventual inability to swallow or breathe. As you can imagine, these problems require extensive medical care and diligence, and interventions which may be very complex. ...Read more

20

20
What is the definition or description of: Amyotrophic lateral sclerosis?

Neurodegenerative: ALS is a neurodegenerative disease of the upper and lower motor neurons. There is a male predominance, and occurs most frequently between the ages of 50 - 60 years. While the most frequent form has a dire prognosis, it does have several variants, with different prognoses that can be prolonged with respect to survival. The diagnosis is based on the clinical findings and robust NCV/EMG studies. ...Read more

21

21
What are the main causes of amyotrophic lateral sclerosis? What can be done to treat it?

See below: We really do not understand the cause, but 10% are genetic and 25% of these are associated with mutations of a gene encoding copper/zinc superoxide dismutase. 90% are sporadic and of no clear causation. There is no cure and control measures are mediocre. The drug Riluzole may delay need to respirator, but most treatments are palliative. ...Read more

22

22
Just heard a close neighbor has amyotrophic lateral sclerosis. How do we explain this condition to the kids?

Weakness: I would explain that it means he will get weak over time, may eventually need a wheelchair, and that his doctors will do everything they can to help him. I would tell them they can't catch it from him, and it is a rare condition, so it is unlikely they or their family members would develop it. ...Read more

23

23
Is amyotrophic lateral sclerosis sex-linked or a chromosomal error?

Is amyotrophic lateral sclerosis sex-linked or a chromosomal error?

ALS: Amyotrophic lateral sclerosis or ALS (lou gehrig's disease) is a central nervous system disease that causes progressive loss of strength and coordination. There are no known risk factors which predispose someone to developing als. Most commonly, the cause is unknown but in about 10% of cases, there is a genetic defect which leads to the problem. ...Read more

24

24
Last advances in the investigation on amyotrophic lateral sclerosis?

Research still slow: A number of established agents have recently been investigated for their potential as neuroprotective agents, including antibiotics and minocycline. Progress has also been made in exploiting growth factors for the treatment of amyotrophic lateral sclerosis, partly due to advances in developing effective delivery systems to the central nervous system but overall out looks so far is not great yet. ...Read more

25

25
Hi doctors, was just wondering what is amyotrophic lateral sclerosis?

Lou Gehrig's disease: Als is a very nasty uncurable disease involving the motor neuron in brain and spinal cord, usually arising in middle to later years of life. It results in a steady deterioration of muscle, with atrophy and fasciculations, possibly eventuating in loss of ability to swallow and breathe. The sole medication on the market which may modestly help is riluzole. ...Read more

26

26
Is it true that amyotrophic lateral sclerosis is a chromosomal error?

10% are familial: And 25% of these involve a mutation of the gene encoding copper/zinc superoxide dismutase. 90% of all cases are sporadic and of unknown etiology. ...Read more

27

27
Do you know if amyotrophic lateral sclerosis is sex linked or a chromosomal error?

Possible: About 10% of cases of ALS are familial, and 30% of these are due to mutations of the gene than encodes copper/zinc superoxide dysmutase. ...Read more

28

28
My grandma has Amyotrophic lateral sclerosis and what medicine she should take for relieving the pain? Or preventing the further complications?

My grandma has Amyotrophic lateral sclerosis and what medicine she should take for relieving the pain? Or preventing the further complications?

Comments: Sole drug on market for ALS is riluzole, which can delay tracheotomy but does not enhance strength. Since it inhibits glutamate, maybe pain relief achieved by use of Lyrica (pregabalin) or gabapentin. Most of the approach in ALS is supportive and palliative. Have a family conference with her neurologist. ...Read more

29

29
What is the treatment for amyotrophic lateral sclerosis?

What is the treatment for amyotrophic lateral sclerosis?

Not good: Lou gehrig's disease remains resistant to successful treatment or control. The drug Riluzole is on the market but is very disappointing, although may delay useage of a tracheostomy tube for a few months. We are learning about a misfolded protein, and this may point the way for future success. ...Read more

30

30
Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Not similar diseases: Als is very different, and is a disease of "mis-folded proteins" like alzheimers and parkinson's, and all of these affect older people.
Ms is an autoimmune disease afflicting younger patients who have hereditary susceptibilities and environmental exposures. Ms can be successfully treated and controlled, but ALS does not respond well to current therapies. ...Read more

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more