Doctor insights on:
Aromatase Inhibitors Medication
If a natural weightlifter took anti cancer medication (aromatase inhibitor), shouldn't his testosterone level increase dramatically?
Increase somewhat: Aromatase inhibitors inhibit the effect of estrogen on the pituitary gland as well as elsewhere. As a result they can increase pituitary hormones that stimulate testosterone production modestly, not usually dramatically. By the way, these medications are banned by most major sports ...Read more
Maybe but for what?: All medications, prescription & otc, as well as all dietary supplements, have potential side effects. There is no free lunch, no side effect free pill, whether medication or supplement. Aromatase inhibitors are approved for use in breast cancer in which case the potential risk of liver damage, hypertension, etc probably outweighs risk of recurrent breast cancer. So talk to your doc re what's right. ...Read more
Benefits > downsides:
Hormonal therapy has systemic benefits in er+ patients (similar to chemo), reduces local recurrence after breast conservation, and reduces the risk of second/new breast cancers. Head to head each of these is slightly better for ais than tamoxifen.
Ais major side effects are menopausal symptoms, bone and joint symptoms (arthralgias), and decrease in bone density. ...Read more
No: If you have been prescribed aromatase inhibitors, presumably you have hormone sensitive breast cancer. Do not substitute the homeopathic placebo for your medications. The data on breast cancer treatment is solid for aromatase inhibitors and using a homeopathic placebo might prove lethal. ...Read more
May be effective: For boys with short stature, and no other known cause, aromatase inhibitors have been used. It is still considered experimental, and it is not clear that it will increase adult height. Much depends on the specific condition. As with anything that may increase testosterone, there are side effects. You should only do this under the care/supervision of a pediatric endocrinologist. ...Read more
Need help in reducing e2 (oestradiol). Need some advice in dosing aromatase inhibitors. Tried arimidex as well as aromasin (exemestane) but got bone mineral loss..
Go see your doctor: Presumably you're taking Arimidex (anastrozole) to control your Estradiol to treat gynecomastia (rather than trying to jack up your testosterone). Loss of bone mineral density is a known consequence of excessively lowering one's estradiol. I'm not clear what kind of trouble you're having w/your dosing since you didn't mention your regimen. Regardless, you need to address your concern w/your doctor. ...Read more
FTM requires two things:
1: I do not take care of such patients unless I am notified by a Psychologist who is taking care of the patient.
2: I do not see any indication for aromatase inhibitors to be given in addition to testosterone.
I have been fortunate to have reasonable success with FTM and MTF. ...Read more
No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read more
No it is not.: Even though it is an over the counter supplement, it is not recommended by any reputable manufacturer to be taken before you are 18. If you are asking about it as a way to increase your testosterone levels, remember if it was successful it would prematurely lead to your bones fusing and stunt your growth/height! ...Read more
Hormonal therapy: Aromatase inhibitors are a form of hormonal therapy for post menopausal patients. They are effective only in er+ cases. They block the conversion of other hormones to estrogen via the enzyme aromatase. In premenopausal patients they actually stimulate the ovaries to increase estrogen production. Hormonal therapy is systemic treatment, reduces local recurrence, and reduces risk of 2nd primaries. ...Read more
Is it safe to take HCG (for wt loss) when on an aromatase inhibitor, ihave taken it previous but was not on the arimadex at the time thanks?
Not defined: I assume the aromatase inhibitors are being used to manage potential or existing metastatic breast cancer. HCG is a hormone developing during pregnancy which does have some beneficial effect on cancer, at least with regard to the n-terminal repeat of the molecule. How it effects breast cancer has not been reported and when used for diet many patients overuse the product and become anorexic. ...Read more
Possibly but...: Much will depend on your specific situation and on your own physician's thoughts after physical examination. I have found that gynecomastia, if persistent, is often best treated with partial excision of the prominent glandular tissue as well as liposuction surgery of the peripheral chest area. ...Read more
Be careful.: Make sure gynecomastia is the correct diagnosis. Breast cancer in male patients is very rare, but can be potentially life threatening. Using medications such as an aromatase inhibitor for breast swelling before eliminating the diagnosis of breast cancer can be potentially serious. Check with your doctor for details. ...Read more
Will taking an aromatase inhibitor combined with finasteride eliminate the sexual side effects caused by finasteride?
Is a potent aromatase inhibitor (letrozole) effevtive in delaying epiphyseal fusion and thus making me grow taller? I am 18 years old
If during the aromatase inhibitor therapy my prostate shrinks to the normal size, can that confirm the cause being elevated estradiol? Thank you.
Huh?: Why are you on an aromatase inhibitor in the first place? ...Read more
Assuming my growt plates have not closed, would an aromatase inhibitor (letrozole) combined with 200mg/ml/month of testosterone make me grow taller?
Genetics: No. But, your growth plates have closed. ...Read more
What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca? Carbo/taxol? Aromatase inhibitor? Other? Clinical trials?
Treatment: We always encourage clinical trials as first line option. Standard therapy will include use of taxane and platinum compound like carboplatin/taxol combo. I would not use arimidex. 2nd line drugs include cisplatin, taxotere, doxil, gemzar, avastin, (bevacizumab) topotecan etc. ...Read more
Is aromatase inhibitor treatment likely to normalize the levels of elevated estradiol, 5-HIAA, histamine and lipid status? Thank you.
What aroma is that??: Yes, and it cures baldness and will get rid of an annoying girlfriend. Well, actually, it just inhibits the conversion of testost to estrogens in your body cells (it works overtime in fat cells).Its relationship to 5-HIAA is sketchy at best (far as I know)and on blood lipids very complex and probably opposite what you think. No easy answers here, except: you gotta histamine problem? Take an antihistamine! ...Read more
Xeloda (capecitabine). Can someone go off Chemo and on an Aromatase Inhibitor after taking Xeloda (capecitabine). I am not menopausal yet and have BC mets to lymph and? Liver?
Yes and No: You have to give us details of your medical history such as when was your breast cancer first diagnosed? When did it becomemetastatic? What all drugs have been used to treat your breast cancer so far. Have you been treated with Tamoxifen before? Did Tamoxifen help control your breast Cancer anytime or it did not? AI's are typically not used in Premenopausal patients because you ovaries are active ...Read more
Low testosterone, low estradiol, high estrone, weight good, taking 200mg testosterone a day at cheek & gum, using a aromatase inhibitor, why low t?
What medical information/product training are oncologists and gynecologists given before they prescribe a drug such as an aromatose inhibitor?
Varies: Usually, drugs such as aromatase inhibitors are first studied in medical school and then residency. In practice, phsycians study new drugs through continuing medical education courses, physician desk reference, and multiple other sources. ...Read more
If its not possible for aromatose inhibitors to affect discs (ddd) how come cigarettes do? (i do not smoke) but am curious as to how!
Nicotine: Theveffecy of nicotine on disc is multifactorial and unknown nicotimecis a potent vasoconstrictor which inhibits healing the disc spacecrzpecially nucleus pulposis has a poor native blood supply less blood ischemia accelerted degentation or mited healing response to daily injuries acclerates degeneration it happens with smoklrss tabacco as well no nicotine no effect in disc. ...Read more
If aromatose inhibitors & ooph can cause osteoporosis, can they also dry out the discs of the spine. I have both problems since ais & ooph?
No: They will not cause disc damage.Get a more detailed answer ›
If aromatose inhibitors can cause me to have severe osteoporosis, can it cause the cervical, lombar, dorsal discs to dry out, too coincidental?
If anastozole (arimiset) possibly caused facial palsy, should it be discontinued or do all aromotase inhibitors contain the same basic ingredients?
Arimidex (anastrozole): On oct, 27, 2012: 12, 989 people reported to have side effects when taking arimidex (anastrozole). Among them, 27 people (0.21%) have facial palsy. The annual incidence in the population is. 02%. Thus there appears to be a slightly greater incidence in those taking arimidex (anastrozole). ...Read more
Can aromatose inhibitors cause osteonecrosis of the jaw? I know bisphosphanates can, but what about other meds?
They do not!: Since they lower Estradiol levels, they can make osteoporosis more likely, but the do not cause osteonecrosis of the jaw! Obviously used for estrogen receptor positive breast ca, Evista (raloxifene) would be a good trade for your tamoxifen, in the sense that it would prevent osteoporosis as well as breast ca! ...Read more