Doctor insights on:
Aromatase Inhibitors Medication
Which bone density medications can be taken with aromatase inhibitors? Which have the fewest side effects? Should I switch to tamoxifen instead?
Bone density loss: In patients who are pre-menopausal with early breast cancer and on aromatase inhibition, fracture prevention is best statistically with denosumab therapy, and supplemental calcium administration. Adjuvant biophosphonates are recommended for patients with documented bone loss (osteopenia or osteoporosis), and those who are peri or post menopausal. ...Read more
If a natural weightlifter took anti cancer medication (aromatase inhibitor), shouldn't his testosterone level increase dramatically?
Increase somewhat: Aromatase inhibitors inhibit the effect of estrogen on the pituitary gland as well as elsewhere. As a result they can increase pituitary hormones that stimulate testosterone production modestly, not usually dramatically. By the way, these medications are banned by most major sports ...Read more
Maybe but for what?: All medications, prescription & otc, as well as all dietary supplements, have potential side effects. There is no free lunch, no side effect free pill, whether medication or supplement. Aromatase inhibitors are approved for use in breast cancer in which case the potential risk of liver damage, hypertension, etc probably outweighs risk of recurrent breast cancer. So talk to your doc re what's right. ...Read more
Benefits > downsides: Hormonal therapy has systemic benefits in er+ patients (similar to chemo), reduces local recurrence after breast conservation, and reduces the risk of second/new breast cancers. Head to head each of these is slightly better for ais than tamoxifen. Ais major side effects are menopausal symptoms, bone and joint symptoms (arthralgias), and decrease in bone density. ...Read moreSee 1 more doctor answer
No: If you have been prescribed aromatase inhibitors, presumably you have hormone sensitive breast cancer. Do not substitute the homeopathic placebo for your medications. The data on breast cancer treatment is solid for aromatase inhibitors and using a homeopathic placebo might prove lethal. ...Read moreSee 1 more doctor answer
May be effective: For boys with short stature, and no other known cause, aromatase inhibitors have been used. It is still considered experimental, and it is not clear that it will increase adult height. Much depends on the specific condition. As with anything that may increase testosterone, there are side effects. You should only do this under the care/supervision of a pediatric endocrinologist. ...Read more
Probably never will: Many of the drugs we use in pediatric oncology are never approved by the fda for treatment of a particular pediatric cancer. Once it gains fda approval for an adult disease indication, we then can study it in clinical trials, and if warranted, use it. ...Read moreSee 3 more doctor answers
Need help in reducing e2 (oestradiol). Need some advice in dosing aromatase inhibitors. Tried arimidex as well as aromasin (exemestane) but got bone mineral loss..
Go see your doctor: Presumably you're taking Arimidex (anastrozole) to control your Estradiol to treat gynecomastia (rather than trying to jack up your testosterone). Loss of bone mineral density is a known consequence of excessively lowering one's estradiol. I'm not clear what kind of trouble you're having w/your dosing since you didn't mention your regimen. Regardless, you need to address your concern w/your doctor. ...Read more
Aromatase: FTM requires two things: 1: I do not take care of such patients unless I am notified by a Psychologist who is taking care of the patient. 2: I do not see any indication for aromatase inhibitors to be given in addition to testosterone. I have been fortunate to have reasonable success with FTM and MTF. ...Read more
No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read moreSee 1 more doctor answer
No it is not.: Even though it is an over the counter supplement, it is not recommended by any reputable manufacturer to be taken before you are 18. If you are asking about it as a way to increase your testosterone levels, remember if it was successful it would prematurely lead to your bones fusing and stunt your growth/height! ...Read more
Hormonal therapy: Aromatase inhibitors are a form of hormonal therapy for post menopausal patients. They are effective only in er+ cases. They block the conversion of other hormones to estrogen via the enzyme aromatase. In premenopausal patients they actually stimulate the ovaries to increase estrogen production. Hormonal therapy is systemic treatment, reduces local recurrence, and reduces risk of 2nd primaries. ...Read moreSee 1 more doctor answer
Is it safe to take HCG( for wt loss) when on an aromatase inhibitor ,ihave taken it previous but was not on the arimadex at the time thanks?
Not defined: I assume the aromatase inhibitors are being used to manage potential or existing metastatic breast cancer. HCG is a hormone developing during pregnancy which does have some beneficial effect on cancer, at least with regard to the n-terminal repeat of the molecule. How it effects breast cancer has not been reported and when used for diet many patients overuse the product and become anorexic . ...Read more
Possibly but...: Much will depend on your specific situation and on your own physician's thoughts after physical examination. I have found that gynecomastia, if persistent, is often best treated with partial excision of the prominent glandular tissue as well as liposuction surgery of the peripheral chest area. ...Read moreSee 2 more doctor answers
Be careful.: Make sure gynecomastia is the correct diagnosis. Breast cancer in male patients is very rare, but can be potentially life threatening. Using medications such as an aromatase inhibitor for breast swelling before eliminating the diagnosis of breast cancer can be potentially serious. Check with your doctor for details. ...Read moreSee 2 more doctor answers
Will taking an aromatase inhibitor combined with finasteride eliminate the sexual side effects caused by finasteride?
Is a potent aromatase inhibitor (letrozole) effevtive in delaying epiphyseal fusion and thus making me grow taller? I am 18 years old
If during the aromatase inhibitor therapy my prostate shrinks to the normal size, can that confirm the cause being elevated estradiol? Thank you.
Huh?: Why are you on an aromatase inhibitor in the first place? ...Read more
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