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Doctor insights on: Aromatase Inhibitors Breast Cancer

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Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

Dr. Barry Rosen
4,428 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Evista (raloxifene) estrogen receptor for uterine cancer?

Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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How’s an aromatase inhibitor used for breast cancer?

How’s an aromatase inhibitor used for breast cancer?

Hormonal therapy: Aromatase inhibitors are a form of hormonal therapy for post menopausal patients. They are effective only in er+ cases. They block the conversion of other hormones to estrogen via the enzyme aromatase. In premenopausal patients they actually stimulate the ovaries to increase estrogen production. Hormonal therapy is systemic treatment, reduces local recurrence, and reduces risk of 2nd primaries. ...Read more

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Dr. Liawaty Ho Dr. Ho
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Chemotherapy hormone receptor positive node breast cancer?

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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Who takes arimidex (anastrozole) for breast cancer?

Who takes arimidex (anastrozole) for breast cancer?

Post menopausal ER+: Women who are post-menopausal and have estrogen receptor positive breast cancer. ...Read more

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Is evista (raloxifene) as effective as tamoxifen in reducing breast cancer?

Is evista (raloxifene) as effective as tamoxifen in reducing breast cancer?

Yes (and no): The study of tamoxifen and Raloxifene (star) trial compared the effectiveness of these two drugs in the prevention of breast cancer and found them to be equally effective, with a 50% reduction in invasive breast cancer as compared to placebo. However, only tamoxifen reduced the rate of carcinoma in situ (dcis, lcis). ...Read more

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Does tamoxifen stop breast cancer from growing?

Does tamoxifen stop breast cancer from growing?

Yes: Tamoxifen is an antiestrogen that blocks the ability of breast cancer cells to use estrogen; therefore, it is only effective in hormone sensitive (estrogen receptor +) breast cancers. When taken for 5 years, tamoxifen has been shown to both stop the growth of cancer cells in breast cancer patients and to prevent the development of breast cancer in women that are at high risk. ...Read more

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Breast cancer prevention?

Breast cancer prevention?

5 steps: 1. Maintain a healthy weight. Obesity increases your risk of breast cancer 2. Have babies and breast feed. These decrease your risk 3. Limit hormone therapy after menopause. 4. Decrease alcohol intake 5. Exercise - women who have regular physical exercise have a decreased risk of breast cancer. ...Read more

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Does pr-negative breast cancer respond to tamoxifen?

Does pr-negative breast cancer respond to tamoxifen?

It depends.: Tamoxifen is used to treat hormone-sensitive breast cancer. This is determined by checking for estrogen receptors (er) and Progesterone receptors (pr) on the cancer. If the cancer is er+ and pr- (or vice-versa), it should respond to tamoxifen. However, if the cancer is er- and pr-, tamoxifen is not effective. ...Read more

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Is dcis breast cancer genetic?

Is dcis breast cancer genetic?

It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read more

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What is estrogen receptor positive breast cancer?

What is estrogen receptor positive breast cancer?

One with receptors.: These are tumors with estrogen receptors on them. This makes them susceptable to some chemotherapeutic agents, like tamoxifen. ...Read more

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Do the breast enhancement pills "breast actives" cause breast cancer or uterus cancer?

Do the breast enhancement pills "breast actives" cause breast cancer or uterus cancer?

Unknown: Breast enhancement pills are not regulated and therefore may have various unknown substances in them. Some of those substances, especially if they include estrogen, may increase risk of cancers. ...Read more

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When is tamoxifen for breast cancer treatment?

When is tamoxifen for breast cancer treatment?

Chemotherapy: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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Can raloxifene drug used if breast cancer?

Not usually: This is a drug like tamoxifen. It is used for risk prevention. It is also used in a condition called lobular cancer in situ, which is a non spreading kind of cancer. It has been used in some cases of breast cancer, but is not the drug of choice. ...Read more

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Can thyroid cancer increase breast cancer risk?

Can thyroid cancer increase breast cancer risk?

Not usually: There are some families who have increased rates of a variety of cancers, including papillary thyroid cancer, breast cancer, and colon cancer. But having one does not cause an risk for another; instead inherited genes put a person at increased risk for both. A person with a history of thyroid cancer should be sure to get recommended mammograms and colon tests. ...Read more

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Is Xeloda (capecitabine) effective for breast cancer?

Is Xeloda (capecitabine) effective for breast cancer?

Xeloda (capecitabine) for breast ca: Xeloda (capecitabine) also known as Capecitabine is a very effective oral chemotherapy drug used for metastatic or stage 4 breast cancer. It can be used by itself (mono therapy) or as part of combination chemotherapy. Major side effects include diarrhea, hand foot syndrome, nausea and small chance of coronary spasm. It is well tolerated. Patients on Xeloda (capecitabine) need to be followed closely by medical oncologists. ...Read more

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Could premerin homone replacement cause Paget breast cancer?

Could premerin homone replacement cause Paget breast cancer?

Unlikely: We think that combined hormone replacement including estrogen and Progesterone cause an increase in breast cancer of which paget's disease if the breast is a type. Premarin (conjugated estrogens) only contains estrogen. ...Read more

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Does breast cancer increase colon cancer risk?

Does breast cancer increase colon cancer risk?

Rarely.: Some hereditary mutations may increase the risk of both breast and colon cancer. Nevertheless, the majority of all breast and colon cancers are not hereditary. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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How’s an aromatase inhibitor used for breast cancer?

Hormonal therapy: Aromatase inhibitors are a form of hormonal therapy for post menopausal patients. They are effective only in er+ cases. They block the conversion of other hormones to estrogen via the enzyme aromatase. In premenopausal patients they actually stimulate the ovaries to increase estrogen production. Hormonal therapy is systemic treatment, reduces local recurrence, and reduces risk of 2nd primaries. ...Read more

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If given a bilat oopherectomy and aromatose inhibitors for breast cancer would the doctor know that these can cause osteoporosis & what should she do?

If given a bilat oopherectomy and aromatose inhibitors for breast cancer would the doctor know that these can cause osteoporosis & what should she do?

YOU know!: It sounds like you are aware of the risk, so tell your doctor! it is great that you are thinking about this. Yes, you are at risk for losing bone, so you need to know 1. Where you are starting (what your bone density is now) 2. Your vitamin d level, and 3. How much your bone density changes in 1-2 years. Keep up weight-bearing exercise like walking, and keep up the conversation with your doc! ...Read more

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What is the difference between anti-estrogens and anti-aromatases for breast cancer?

What is the difference between anti-estrogens and anti-aromatases for breast cancer?

"cousin-drugs": Tamoxifen ("anti-estrogen") and aromatase inhibitors (ai) are both used for treating breast cancers that are estrogen-receptor +. Ai's are only suitable after menopause but may be slightly more effective; furthermore, they are not associated with any increased risk of uterine cancer like tamoxifen. ...Read more

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Why does my breast cancer come back? I have had radiation, chemo 2x and surgeries. I have been on several aromase inhibitors a nd had a tram flap

Why does my breast cancer come back? I have had radiation, chemo 2x and surgeries. I have been on several aromase inhibitors a nd had a tram flap

Residual tumor: When tumors of breast are resected primarily, many have tumor close to bx margins. Here radiation fails in about 20% and disease will then spread. Reresection for margins essential. The issue of recurrence also depends on the size of the primary lesion, greater than 2.5 cm. and the status of the hormone receptors. If one has a triple negative lesion then the response to many treatments poor. ...Read more

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Dr. Liawaty Ho Dr. Ho
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How common is breast cancer?

Dr. Liawaty Ho Dr. Ho
7 doctors agreed:
How common is breast cancer?

Pretty common : Estimated new cases and deaths from breast cancer in the United States in 2012: new cases: 226, 870 (female); 2, 190 (male) and 39, 510 (female); 410 (male) deaths. Lifetime risk is 1 to 8. Risk is higher with the increased of age. ...Read more

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Dr. Liawaty Ho Dr. Ho
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How can breast cancer spread?

Dr. Liawaty Ho Dr. Ho
2 doctors agreed:
How can breast cancer spread?

3 ways: It spread through lymphatic organ ( lymph glands) , through blood circulation and direct invasion to the adjacent organ such as skin, chest wall etc. ...Read more

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How does breast cancer spread?

Circulation: Most breast cancers begin in the breast ducts, where milk is transported to the nipple. Invasive cancers break out of the duct and spread to the adjacent supportive tissue within the breast, where the lymphatics and blood vessels are found. These cancer cells may enter these vessels and travel anywhere in the body. ...Read more

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How can breast cancer develop?

One mutant cell: One normal cell inside your breast mutates (becomes abnormal), and begins to grow. The normal "stop" signal that tell a cell to stop dividing doesn't work, so the cells keep dividing. One cell becomes two, two become four, four become eight, etc. It takes millions of cancer cells to form a tumor you can feel. ...Read more

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How does breast cancer develop?

How does breast cancer develop?

One mutant cell: One normal cell inside your breast mutates (becomes abnormal), and begins to grow. The normal "stop" signal that tell a cell to stop dividing doesn't work, so the cells keep dividing. One cell becomes two, two become four, four become eight, etc. It takes millions of cancer cells to form a tumor you can feel. ...Read more

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Whom does breast cancer affect?

Whom does breast cancer affect?

One-In-Eight Women: A common misconception is that women without a family history need not worry about breast cancer. In truth, most breast cancers occur in women with no risk factors. Furthermore, the incidence increases with age. Every woman needs to have regular screening mammograms beginning at age 40. ...Read more

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Why don't men get breast cancer?

Why don't men get breast cancer?

They do: Male breast cancer exists, but is only 1% of breast ca. Females develop breast tissue in response to hormones at levels that men don't achieve. If men take certain hormone medications, their breast tissue can grow. Breast cancer cells can be estrogen sensitive, so genetic males taking estrogen or with liver dz may be at increased risk. Brca gene can also increase risk, as in females. ...Read more

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Does estradi case breast cancer?

Does estradi case breast cancer?

Possibly: Estrogen receptor type of cancer incidence fell after scientific studies linking estrogen use with increased risk of breast cancer caused many women to discontinue their use, but other studies gave less convincing conclusions. ...Read more

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Can my friend have breast cancer?

Can my friend have breast cancer?

???: You need to give us more info but the answer would be: anybody can have cancer. Advise your friend to see a doctor if there is any concerning symptom but in the end is his/her choice. ...Read more

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How do you diagnose breast cancer?

How do you diagnose breast cancer?

Biopsy: Diagnosis is made through a biopsy that is either performed through the skin with a needle or by a surgical procedure. ...Read more

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Does mastis lead to breast cancer?

Does mastis lead to breast cancer?

No: Mastitis is describing inflammation. A swollen breast though may hide cancer and sometimes and underlying cancer can manifest swelling and redness in the breast. ...Read more

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Diagnosed w/breast cancer. What now?

See a surgeon: You will need referrals from your doctor to see a breast cancer surgeon who specializes in breast cancer treatment, and a medical oncology specialist. Most often lumpectomy surgery (or also called partial mastectomy) and post -operative hormone therapy or chemotherapy and possible radiation therapy is indicated. There is a very high success rate in treating breast cancer. ...Read more

Dr. Liawaty Ho Dr. Ho
14 doctors agreed:
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Can you please explain breast cancer?

Dr. Liawaty Ho Dr. Ho
14 doctors agreed:

Cancer of the breast: Cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare. Read more here : http://cancer.Gov/cancertopics/wyntk/breast. ...Read more

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Dr. Mark Hoepfner
1,070 doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more


Aromatase Inhibitors (Definition)

An aromatase inhibitor is a medicine that blocks the conversion of androgens in fat cells to ...Read more