Doctor insights on:
Are There Treatment Guidelines For Bone Metastases
Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more
Clinical trial: Clinical trial or standard chemotherapy. Bone mets can be treated with bisphosphonate (zometa) or Denosumab (xgeva). Mri of the brain should evaluate for brain mets. Trials: http://clinicaltrials.Gov/ct2/results?Term=small+cell+lung+cancer&recr=open&no_unk=y standard of care chemotherapy is a 2 drug combination with a "platinum". ...Read more
What can we expect from a stage 4 lung cancer patient with bone metastases- what can be done in case all treatments are ruled out?
Biomarkers in lungCA: For stage 4 non-small cell lung cancer -- specifically adenocarincoma -- i would check the biomarkers alk and egfr. The response rate with oral drugs for those targets is ~80% vs. 20% with chemo. Bone mets can be treated with bisphosphonate (zometa) or Denosumab (xgeva). Palliative care provided early has a survival benefit. Ref: temel et al. Nejm http://www.Nejm.Org/doi/pdf/10.1056/nejmoa1000678. ...Read moreSee 1 more doctor answer
Like termites,: Abnormal cells destroy bone integrity after traveling from the cancer by the blood stream to a new place. When they grow, they can cause bones to collapse, leading to pain and fracture, or expand causing pain. In many tumors, this is characteristic (prostate, myeloma), treatment can be chemical, radiotherapy, and surgery. ...Read moreSee 2 more doctor answers
X-ray,bone scan: Sometimes bone metastases (bone mets) are found before they have a chance to cause any symptoms. When you are found to have cancer, your doctor may order tests (like x-rays or bone scans) to see how far the cancer has spread. This may be done before, during, and after treatment. In other cases, a symptom such as bone pain may be the first sign of bone mets. ...Read more
Bone Mets = spread -: of the cancer to bones, and the shadows seen on the Xrays are the osteolytic lesions ( basically the spreading cancer lodges in the bone). Treatment depends on the location of the cancer (whether its from breast, thyroid, kidney or lung) spreading to the Bone, and extent of the bone involvement. In long bones these lesions can be bypassed using a Rod in the bone to stabilize it. See Orthopod. ...Read more
It depends: There are 2 factors that are important. One is the type of cancer and the second is the response to treatment. For metastatic breast or prostate cancer to bone that responds to hormone treatment it could be years. For melanoma that is not responsive it could be a few months. ...Read more
Bony mets: It means that he has a cancer outside the bone that has spread to the bone. Prostate will be the most common cause of bony mets in man- however , other cancers like lung, thyroid, kidney cancers and breast cancer in female are commonly also spread to the bone. Treatment for bone mets will be directed to relieve the symptoms created by the bone mets=pain, fracture, compression, hypercalcemia etc. ...Read moreSee 1 more doctor answer
Other modalities: Conventional x-rays, ct scans, pet scans and bone scans are the ways that we usually detect bone metastasis in cancer work ups. Bone density scans are not used for this purpose, but instead are used to document osteoporosis, and determine treatment to replace lost calcium in bones that can lead to benign fractures. ...Read more
A cancer begins in an organ (say the breast). If it gets into the blood stream or the lymphatic stream the cells can travel to other parts of the body where, in the right environment, they may settle and grow. This development of tumor growth far away from the original site ...Read more
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