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Doctor insights on: Are There Differences Between Zoloft And Effexor

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Are there differences between Zoloft and effexor (venlafaxine)?

Are there differences between Zoloft and effexor (venlafaxine)?

Yes: Zoloft is serotonergic in nature. Effexor (venlafaxine) in low doses is also. At higher doses effexor's noradrenergic. Zoloft has fewer significant side effects - Effexor (venlafaxine) has more including at times severe withdrawal effects compared to zoloft. Studies show Effexor (venlafaxine) to be more effective in severe depression than other antidepressants. With its dual nature Effexor (venlafaxine) doesn't seem to lose effectiveness like zoloft. ...Read more

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Dr. Krishna Kumar
536 doctors shared insights

Venlafaxine (Definition)

It belong to classification of snri antidepressant also help anxiety start slow go slow its approved for depression and anxiety disorder there are some common side effects important never stop suddenly always taper slowly if you ever ...Read more


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What is the difference between Effexor (venlafaxine) and zoloft?

What is the difference between Effexor (venlafaxine) and zoloft?

The difference : Between zoloft and Effexor (venlafaxine) is in the the chemicals they target in the brain. Zoloft targets serotonin while Effexor (venlafaxine) targets both serotonin and norepinephrine. ...Read more

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Is Effexor (venlafaxine) right for me? 200mg Zoloft daily doesn't work. I am a diabetic I have been taking Zoloft for 12 years now and it always worked in the past. Thanks for your help!

Is Effexor (venlafaxine) right for me? 200mg Zoloft daily doesn't work. I am a diabetic I have been taking Zoloft for 12 years now and it always worked in the past. Thanks for your help!

Hello. : Hello. I don't know what condition you are taking the zoloft for. Ptsd? Anxiety disorder? Depression? The first issue is to ensure that your diagnosis is correct. Although 200mg of zoloft is the maximum recommended dose in the pdr; it is often prescribed off - label at higher doses. Some of the concerns with Effexor (venlafaxine) is that to get a dose that has more than just an effect on serotonin levels; you could have problems with weight gain and hypertension. Some patients need a medication combination or a mood stabilizer good luck. ...Read more

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Is Zoloft better drug than Effexor (venlafaxine)? I heard more people using Zoloft than Effexor (venlafaxine).

Is Zoloft better drug than Effexor (venlafaxine)? I heard more people using Zoloft than Effexor (venlafaxine).

Nope: One is not better than the other. Response rates are similar for major depression. Differences in potential side-effects and drug-interactions. Cost basis is similar for both (despite what the retail pharmacy might want to sell it to you for). ...Read more

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I tried to quit effexor (venlafaxine) xr but the symptoms came back. Psch put me on zoloft 200m mg. How much time will it take to work?

I tried to quit effexor (venlafaxine) xr but the symptoms came back. Psch put me on zoloft 200m mg. How much time will it take to work?

Variable: This is a good question. As soon as a person takes a dose of Zoloft (sertraline) (or any SRI) their levels of serotonin in their brain begin to change. Some individuals likely benefit from that alone However...the secondary therapeutic actions relate to changes on the surface of the nerve cell which requires more complex mechanisms i.e protein synthesis...and this can take 2-4 weeks. So time is needed. ...Read more

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Was on 75mg of Effexor (venlafaxine) for last 7 weeks and have been upped to 150mg for the last week or so. Feel worse than what i was when i was on Zoloft.

Was on 75mg of Effexor (venlafaxine) for last 7 weeks and have been upped to 150mg for the last week or so. Feel worse than what i was when i was on Zoloft.

Let treating dr know: It is common for some medications to work well and others may not work as well. You need to let your treating Dr. know and medications may need to be adjusted or switched until the right one or combination of them works best for you. Good luck. ...Read more

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Currently take 200mg Zoloft daily and Dr. has now added Effexor (venlafaxine) XR 75mg daily. Is this a problem? What alternatives should I discuss with Dr.?

Seems like a lot: Zoloft 200 mg is a pretty high dose. You may want to ask him about weaning down on the Zoloft as he's increasing the Effexor XR. You may also want to ask about another class of medication instead of the Effexor XR such as wellbutrin, buproprion or abilify, (aripiprazole) depending on your diagnosis. ...Read more

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Is it safe to take Effexor (venlafaxine) XR along with taking zoloft?

Safe: Safe is such a relative term. Whenever taking multiple meds you run the risk of interactions or side effects. With that being said, realize that Effexor (venlafaxine) affects norepinephrine and seretonin, both of which are neurotransmitters associated with dep and anx; whereas, zoloft targets mainly seretonin. If prescribed both, attention needs to be paid to developing seretonin syndrome, which is an overload. ...Read more

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Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Zoloft (sertraline): Yes it is. Dopamin reuptake inhibition increases as dose increase. ...Read more

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Currently taking 200mg Zoloft. Effexor (venlafaxine) XR started 07/01/14. Since Effexor (venlafaxine) Iam losing weight.went from 297 to 280. Is this a cause for concern?

Currently taking 200mg Zoloft. Effexor (venlafaxine) XR started 07/01/14. Since  Effexor (venlafaxine) Iam losing weight.went from 297 to 280. Is this a cause for concern?

No: losing weight is possible on these medications but you need to check with your provider to see if you should be on two drugs in the same family which could cause some problems like serontonin syndrome Please check with provider but I do see weight loss with some antidepressants (sometimes they gain weight) ...Read more

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I take Zoloft a.M.Plus wellbutrin 150 in the morning and at night. I travel a lot and cannot always obtain wellbutrin. Friends have advised effexor (venlafaxine). ?

I take Zoloft a.M.Plus wellbutrin 150 in the morning and at night.  I travel a lot and cannot always obtain wellbutrin. Friends have advised effexor (venlafaxine). ?

Do not listen : To friends. Effexxor and wellbutrin work on different parts of the brain. You can not substitue one for the other. If you miss a dose of wellbutrin you will not have ill effects of withdrawal. If you missed medications on several days of either zoloft or Effexor (venlafaxine) you would. You should stick with the wellbutrin especially if it is working with you. There is a vacation override to get enough for trav. ...Read more

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I have gained 20 pounds in 9 months from Effexor (venlafaxine). Will I be able to lose the weight if I switch to Zoloft or will Zoloft cause the same weight gain problem ?

I have gained 20 pounds in 9 months from Effexor (venlafaxine).
Will I be able to lose the weight if I switch to Zoloft or will Zoloft cause the same weight gain problem ?

Sorry, no promises: Each person is unique. It's a troubling side effect and for some it is a reason to taper off and try other drugs but most can have this effect for some. Trial and error is all there is. Adding CBT therapy will reduce the need for high doses, long term use and improve outcome. Think about seeing someone. Best! ...Read more

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I've been on Effexor (venlafaxine) XR for about 5 weeks now. While i feel it's helping in some ways, my anxiety and obsessive thoughts are still there. I'm also scared for the withdrawal. I read Zoloft may help?

Discuss with your MD: If Effexor (venlafaxine) is not helping, you may need increase in dose or you can increase the dose to maximum tolerable dose or can be switched to ssri group of drugs like zoloft, Paxil or lexapro.You should discuss with your psychiatrist what is best for you.You also have hypothyroidism which can also contributes to the symptoms of depression and need to correct that with proper dose of levothyroxin, by your md. ...Read more

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Is Effexor (venlafaxine) more effective for panic disorder than Zoloft?

Is Effexor (venlafaxine) more effective for panic disorder than Zoloft?

Different strokes...: The polls of patients say slightly more prefer Zoloft (sertraline) for panic, but it's a very unique fit. Neither was initially for that - they're antidepressants. That said it's often effective for panic and much, more combined w/ CBT therapy. Discuss w/ Dr. Don't do it yourself! ...Read more

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I switched from 200mg of Zoloft a day to 75mg of Effexor (venlafaxine) a day. I feel funny. Is it the change in medicine that's causing it? Dizzy and funny feeling

Yes: This change in meds could be producing the "funny feeling" you describe. Both meds act on similar and different neurotransmitter systems (serotonin and norepinephrine). It may be been an easier transition to taper a little more slowly with Zoloft (Sertraline) and add Effexor (venlafaxine) at a lower dose (37.5mg) to adjust. ...Read more

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Tried zoloft, celexa, now on remeron with Effexor (venlafaxine). If this doesn't work what would be next ? Losing hope with these meds.

Tried zoloft, celexa, now on remeron with Effexor (venlafaxine). If this doesn't work what would be next ? Losing hope with these meds.

Try CBT: All research comsistently finds that optimal treatment includes good CBT therapy and your active involvement. With or without medication, results are sugnificantly better. You learn skills to manage your life overall and if you miss this part - it's very hard to make things better. Best wishes! ...Read more

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Celexa made me feel "flat" Zoloft was great but allergic Paxil gave me worst anxiety Effexor (venlafaxine) didn't notice much what is the right med for my anxiety?

Celexa made me feel "flat" Zoloft was great but allergic Paxil gave me worst anxiety Effexor (venlafaxine) didn't notice much what is the right med for my anxiety?

More choices: You and your doctor still have more possible choices, although you've tried several. If you've not yet been working with a psychiatrist, please do. Without a comprehensive psychiatric evaluation, i can't comment on a "right med" for your anxiety. You ; your doctor should partner together to help you -- and psychotherapy is an important part of your recovery also. ...Read more

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I've tried Zoloft panic remeron Effexor and I can't get past the extreme anxiety from starting the meds. I don't know what else to do frustrated ?

I've tried Zoloft panic remeron Effexor and I can't get past the extreme anxiety from starting the meds. I don't know what else to do frustrated ?

Untreated anxiety?: Sounds like you sincerely want a cure, but have yet to start medications prescribed? A paradox to be sure, but the drugs can't help if they sit in the bottle. Don't go it alone. Sounds like the best and most courageous course of action is to heed your doctor's advice. Be well-- ...Read more

Dr. Heidi Fowler
1,073 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Effexor (Definition)

Venlafaxine is a non-tricyclic which is a kind of serotonin-norepinephrine reuptake inhibiting drug (atypical anti-psychotic ...Read more