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Doctor insights on: Are Some People More Prone To Getting Serum Sickness

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Are some people more prone to getting serum sickness?

Are some people more prone to getting serum sickness?

Serum sickness: Classic serum sickness is caused by administration of a protein antigen from a non-human species. There have been some case reports implicating the drugs Rituximab and Infliximab (used to treat chron's disease and rheumatoid arthritis). Rarely, repeated blood transfusions, insect stings, and mosquito bites can cause serum sickness-type reactions. ...Read more

Dr. Dariush Saghafi
15 doctors shared insights

Serum Sickness (Definition)

Serum sickness is a type of hypersensitivity reaction (type iii immune reaction) that occurs when the immune system develops antibodies to a foreign protein. The antibody and the foreign protein combine to form an immune complex (ic) that can settle in areas of the body such as the joints or the kidney. The ic can damage these areas and cause arthralgias ...Read more


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Whats serum sickness?

Whats serum sickness?

Systemic allergic : Systemic allergic response in which antibody-antigen reaction in the blood stream causes systemic problems. ...Read more

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Can serum sickness be cured?

Can serum sickness be cured?

Yes: The most common treatment for serum sickness is discontinuation of the offending drug, combined with the use of both antihistamines and glucocorticoids. Withdrawal of the drug by itself is usually sufficient treatment for patients with mild symptoms. Fever and joint pains resolve within 48 hours. To prevent recurrence, the culprit drug should be avoided in the future, if possible. ...Read more

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How can I treat serum sickness?

How can I treat serum sickness?

Avoidance: Not much can be done specifically to treat serum sickness, other than avoiding the antigen that caused it in the first place. If there is significant joint or other inflammation, steroids can help reduce the symptoms while waiting for the reaction to go away. ...Read more

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Can you die from serum sickness?

Can you die from serum sickness?

Unfortunately...Yes: Serum sickness got it's name from reactions after treatments with high doses of horse serum given for treatments snake bites or tetanus. Antibiotics can also cause this. The persons antibodies clump with the foreign serum proteins. These clumps (immune complexes) can clog small blood vessels in the skin, mucous membranes, joints, kidneys and intestines. Fulminant severe reaction can be fatal. ...Read more

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Has anyone else had serum sickness?

Has anyone else had  serum sickness?

Serum Sickness: Serum sickness is a reaction that is similar to an allergy. The immune system reacts to medications that contain injected proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that contains antibodies given to a person to help protect them against germs or poisonous substances. ...Read more

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Are the symptoms of serum sickness bad?

Are the symptoms of serum sickness bad?

Can be: Serum sickness usually causes fever, lymph node enlargement, arthritis, muscle pain, weakness, renal disease, severity of the disease would determine the severity of symptoms. ...Read more

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Has anyone ever heard of "serum sickness"?

Has anyone ever heard of "serum sickness"?

Systemic allergic : Systemic allergic response in which antibody-antigen reaction in the blood stream causes systemic problems. ...Read more

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Can I die from serum sickness if I ignore it?

Can I die from serum sickness if I ignore it?

Yes: Serum sickness can lead to organ damage and vascular collapse if the offending agent is not stopped. Normally however it is a self-limited syndrome which resolves after the offending agent is removed. ...Read more

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What is the definition or description of: serum sickness?

What is the definition or description of: serum sickness?

Hypersensitivity: Serum sickness is a type of hypersensitivity reaction (type iii immune reaction) that occurs when the immune system develops antibodies to a foreign protein. The antibody and the foreign protein combine to form an immune complex (ic) that can settle in areas of the body such as the joints or the kidney. The ic can damage these areas and cause arthralgias and glomerulonephritis for example. ...Read more

Serum (Definition)

Serum is the component of blood that does not contain cells or clotting factors. It does contain electrolytes an ...Read more