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Doctor insights on: Are Obese People Resistant To Leptin

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Are obese people resistant to leptin?

Are obese people resistant to leptin?

Yes: Although leptin is a circulating signal that reduces appetite, obese individuals generally exhibit an unusually high circulating concentration of leptin. These people are said to be resistant to the effects of leptin, in much the same way that people with type 2 diabetes are resistant to the effects of insulin. ...Read more

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Dr. Quang Nguyen
4,506 doctors shared insights

Obesity (Definition)

The definition started with Louis Israel Dublin, chief statistician of the Metropolitan life insurance company, in the early 1940s, as a BMI >25 (definitely >30) for people in their 20's based on retrospective observational life insurance data of the age at which people died later in life. This was subsequently adopted by the medical disease industry. However, BMI is ...Read more


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Besides leptin, what's another biomarker for obesity.?

Besides leptin, what's another biomarker for obesity.?

There are several: There are several factors including ghrelin and also Insulin metabolism that are important. ...Read more

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Leptin and ghrelin hormones and obesity. Is there a connection?

Leptin and ghrelin hormones and obesity. Is there a connection?

Yes: There are many hormones that help modulate energy balance in the body. Leptin is one hormone (of many) that makes you feel full. Ghrelin is one hormone (of many) that makes you feel hungry. There are other hormones and neurotransmitters that keep the system redundant and hard to modify. ...Read more

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Can you tell me about animals with a leptin deficiency or a defect in leptin receptors exhibit hyperphagia (overeating) and extreme obesity. Why?

Can you tell me about animals with a leptin deficiency or a defect in leptin receptors exhibit hyperphagia (overeating) and extreme obesity. Why?

Humans: Not sure about animal research but here's a helpful reference for humans: http://ghr.Nlm.Nih.Gov/condition/congenital-leptin-deficiency. ...Read more

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I am a narcoleptic with cataplexy. Does that mean I am leptin resistant and need to take leptin supplements or go on a leptin diet?

I am a narcoleptic with cataplexy. Does that mean I am leptin resistant and need to take leptin supplements or go on a leptin diet?

No....: The "leptic" in narcoleptic does not stand for "leptin". The full name of the condition is narcolepsy and it is characterized by the sudden onset of sleep. There are treatments available so be sure to follow up with the doctor who diagnosed you. ...Read more

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How can the leptin diet work?

How can the leptin diet work?

Fat controlling: Hormone , or some times called 'starvation hormone ' controls its deposition , depletion , ( putting fat on or taking it off ) . There is no convincing scientific proof by exogenous intake , ( food or pills ) it will do the same , only one who gets benefit is the one who makes and sells.. Only proven way to loose weight , limiting intake , spending more time in gym , no time on couch ...Read more

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How can the leptin diet work?

How can  the leptin diet work?

It probably doesn't: All diets are the same , low calorie, low carb and some supplements that should suppress appetite, like leptin. The problem is these experiments are conducted in mice and humans do not respond the same way to these meds. Very hard to lose weight but cutting calories and moving more can help. ...Read more

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Which type of food decreases leptin?

Which type of food decreases leptin?

Supplement glutamine: Instead of focusing on leptin diet if you take l-glutamine supplements 1000mg at night and any time you have cravings you can turn on the satiation response in brain and naturally start the weight loss. ...Read more

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What "activates " your leptin to lose weight?

What "activates " your leptin to lose weight?

Not so simple: Leptin does help regulate weight by curbing appetite and the amount of leptin you make is directly related to how much fat you have stored, However, overweight people seem to become resistant to the appetite effects of leptin and continue to eat more than they need even with high leptin levels. There is no way to activate your leptin - it is there but not working to help you lose weight ...Read more

Dr. Robert Cabay
518 doctors shared insights

Leptin (Definition)

Leptin is a hormone (a chemical made in one part of the body that is carried by the blood to other parts of the body) made by fat cells, and may have effects on appetite and the way ...Read more