Doctor insights on:
Are Obese People Resistant To Leptin
Yes: Although leptin is a circulating signal that reduces appetite, obese individuals generally exhibit an unusually high circulating concentration of leptin. These people are said to be resistant to the effects of leptin, in much the same way that people with type 2 diabetes are resistant to the effects of insulin. ...Read moreSee 1 more doctor answer
The definition started with Louis Israel Dublin, chief statistician of the Metropolitan life insurance company, in the early 1940s, as a BMI >25 (definitely >30) for people in their 20's based on retrospective observational life insurance data of the age at which people died later in life. This was subsequently adopted by the medical disease industry. However, BMI is ...Read more
Yes: There are many hormones that help modulate energy balance in the body. Leptin is one hormone (of many) that makes you feel full. Ghrelin is one hormone (of many) that makes you feel hungry. There are other hormones and neurotransmitters that keep the system redundant and hard to modify. ...Read more
Can you tell me about animals with a leptin deficiency or a defect in leptin receptors exhibit hyperphagia (overeating) and extreme obesity. Why?
Perindopril reduces leptin levels in obese patients.Will it increase weight?Are there any medicines 2 increase Amylin&leptin 4 weight loss?Plz help
I am a narcoleptic with cataplexy. Does that mean I am leptin resistant and need to take leptin supplements or go on a leptin diet?
Biochemical markers: There is no known standardized test at this time. Leptin levels are . The following findings correlate with leptin resistance: morning blood sugar > 95; hbac1n >5.6; positive microalbumin test; elevated LDL and triglycerides with a low hdl; low testosterone levels in men; non alcohollic fatty liver disease (ultrasound test); polycystic ovarian syndrome in women; central obesity pattern. ...Read moreSee 1 more doctor answer
Hunger decreases: Leptin is a neuro-transmitter produced by fat cells that tell the brains that you need calories (starvation indicator), When it falls you get the sensation of hunger. When it rises you become satiated. This may help: http://www.webmd.com/diet/obesity/the-facts-on-leptin-faq ...Read more
A hormone: Hi. Leptin is a hormone made by adipose tissue (fat cells) that has the effect on the satiety center in the hypothalamus in the brain to tell you you're full, it's OK to stop eating. Obese people are leptin resistant, not leptin deficient. A leptin receptor agonist, metreleptin, was recently approved for treatment of people with little/no adipose tissue (generalized lipodystrophy). ...Read more
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