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Doctor insights on: Are Obese People Resistant To Leptin

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Are obese people resistant to leptin?

Are obese people resistant to leptin?

Yes: Although leptin is a circulating signal that reduces appetite, obese individuals generally exhibit an unusually high circulating concentration of leptin. These people are said to be resistant to the effects of leptin, in much the same way that people with type 2 diabetes are resistant to the effects of insulin. ...Read more

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Dr. Quang Nguyen
4,559 doctors shared insights

Obesity (Definition)

Having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat, and/or body water. Both terms mean that a person's weight is greater than what's considered healthy for ...Read more


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Besides leptin, what's another biomarker for obesity.?

Besides leptin, what's another biomarker for obesity.?

There are several: There are several factors including ghrelin and also Insulin metabolism that are important. ...Read more

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Leptin and ghrelin hormones and obesity. Is there a connection?

Leptin and ghrelin hormones and obesity. Is there a connection?

Yes: There are many hormones that help modulate energy balance in the body. Leptin is one hormone (of many) that makes you feel full. Ghrelin is one hormone (of many) that makes you feel hungry. There are other hormones and neurotransmitters that keep the system redundant and hard to modify. ...Read more

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Can you tell me about animals with a leptin deficiency or a defect in leptin receptors exhibit hyperphagia (overeating) and extreme obesity. Why?

Can you tell me about animals with a leptin deficiency or a defect in leptin receptors exhibit hyperphagia (overeating) and extreme obesity. Why?

Humans: Not sure about animal research but here's a helpful reference for humans: http://ghr.Nlm.Nih.Gov/condition/congenital-leptin-deficiency. ...Read more

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I am a narcoleptic with cataplexy. Does that mean I am leptin resistant and need to take leptin supplements or go on a leptin diet?

I am a narcoleptic with cataplexy. Does that mean I am leptin resistant and need to take leptin supplements or go on a leptin diet?

No....: The "leptic" in narcoleptic does not stand for "leptin". The full name of the condition is narcolepsy and it is characterized by the sudden onset of sleep. There are treatments available so be sure to follow up with the doctor who diagnosed you. ...Read more

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How can the leptin diet work?

How can the leptin diet work?

Fat controlling: Hormone , or some times called 'starvation hormone ' controls its deposition , depletion , ( putting fat on or taking it off ) . There is no convincing scientific proof by exogenous intake , ( food or pills ) it will do the same , only one who gets benefit is the one who makes and sells.. Only proven way to loose weight , limiting intake , spending more time in gym , no time on couch ...Read more

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How can the leptin diet work?

How can  the leptin diet work?

It probably doesn't: All diets are the same , low calorie, low carb and some supplements that should suppress appetite, like leptin. The problem is these experiments are conducted in mice and humans do not respond the same way to these meds. Very hard to lose weight but cutting calories and moving more can help. ...Read more

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Which type of food decreases leptin?

Which type of food decreases leptin?

Supplement glutamine: Instead of focusing on leptin diet if you take l-glutamine supplements 1000mg at night and any time you have cravings you can turn on the satiation response in brain and naturally start the weight loss. ...Read more

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What "activates " your leptin to lose weight?

What "activates " your leptin to lose weight?

Not so simple: Leptin does help regulate weight by curbing appetite and the amount of leptin you make is directly related to how much fat you have stored, However, overweight people seem to become resistant to the appetite effects of leptin and continue to eat more than they need even with high leptin levels. There is no way to activate your leptin - it is there but not working to help you lose weight ...Read more

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What effect does dieting have on leptin levels?

Lowers level: If dieting is intended to lower fat content, then there should be expected drop in leptin levels as this hormone (cytokine) is produced by the fat cells (adipocytes). ...Read more

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What is the role of leptin in weight management?

What is the role of leptin in weight management?

Inhibits appettite: Leptin hormone tells your brain that you are full and do not need to eat anymore. ...Read more

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Is there an after effect of a 'leptin deficiency'?

Is there an after effect of a 'leptin deficiency'?

Fat hormone: Leptons are hypothesized to be a hormone released to control fat metabolism. It has been shown in mice to be effective in fat control, but not in humans. At this point, there are no significant effects of a deficiency. ...Read more

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Does leptin affect your bra size?

Does leptin affect your bra size?

Breast size: There are studies regarding leptin & obesity, breast cancer etc. I don't believe that there is any hard data that leptin will specifically increase your breast size. Maybe one of the breast specialist physicians will weigh in on this. ...Read more

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What happens when leptin levels rise?

What happens when leptin levels rise?

Hunger decreases: Leptin is a neuro-transmitter produced by fat cells that tell the brains that you need calories (starvation indicator), When it falls you get the sensation of hunger. When it rises you become satiated. This may help: http://www.webmd.com/diet/obesity/the-facts-on-leptin-faq ...Read more

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Which fruits have leptin?

Which fruits have leptin?

May cause weightgain: Recently, a study was published that may possibly exhibit a link between fruit consumption and weight gain. The study determined that high consumption of fructose may well be a cause of leptin resistance. By eating fruit, you can help the natural occurring leptin to help increase your body's metabolism function - high leptin is correlated with leptin resistance. ...Read more

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Are leptin and diabetes related?

Evidence suggests ..: Leptin signals the brain that the body has had enough to eat, producing a feeling of satiety. A very small group of humans possesses homozygous mutations for the leptin gene, leading to a constant desire for food and resulting in severe obesity. Over consumption of carbohydrates without sufficient exercise can lead to Insulin resistance and blood sugar elevation which characterize diabetes. ...Read more

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Dr. Robert Cabay
518 doctors shared insights

Leptin (Definition)

Leptin is a hormone (a chemical made in one part of the body that is carried by the blood to other parts of the body) made by fat cells, and may have effects on appetite and the way ...Read more