Doctor insights on:
Are Myelofibrosis And Multiple Myeloma Are Related To Each Other
Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Is it necessary to take dexa along with Velcade (bortezomib) same day for multiple myeloma patient of 80 yrs as acute diarrhea is encountered after every dose?
See below: Velcade may produce diarrhea, but DEX usually not. Velcade and DEX have been given same day only for the convenience, and I see no reason to try to give them on separate days. Alternatively, one can reduce the dose of Velcade or try anti-diarrhea agent prophylactively, such as imodium (loperamide). Diarrhea needs to be treated with antidiarrhea agents and electrolytes monitoring. ...Read more
My father 80 yrs is under treatment with Velcade (bortezomib) for multiple myeloma a After 2 cycles he is facing acute diarrhea after every injection kindly guide?
Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?
Homeopathy, herbs ;: There are no proven alternatives for multiple myeloma but that does not mean they may not help; but I would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. ...Read more
Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more
The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more
Plasma cell cancer:
Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. ...Read more
None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more
Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Nephropathy: Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney. ...Read more
Myeloma has a variable natural history. Many patients have had myeloma for years prior to diagnosis without realizing it, while others are diagnosed by screening for monoclonal protein in the blood.
Modern hematologists can use advanced treatments like velcade, revlimid, (lenalidomide) thalomid, and stem cell transplant, allowing myeloma patients to live longer than ever. More info: http://bit. Ly/lrzotm. ...Read more
No: I would not recommend hydroxycut under any circumstances. ...Read more
Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now. ...Read more
Nobody knows: Bottom line is that nobody knows for sure. No serious studies have correlated multiple myeloma and stress, so this would be an unlikely cause. Genetic abnormalities ate involved in causing this disease but is hard to figure out what is exactly causing such genetic abnormalities. Best wishes, ariel. ...Read more
Years: This really varies depending most importantly on the chromosome abnormalities. Patients with this diagnosis are living longer, whereas previously many died within 3 years, most are living much longer. ...Read more
Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis (SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma. ...Read more
Not clear: There is no correct answer for this. Many patients receiving bisphosphonates for active myeloma receive regular treatment for approximately 2 years. In some cases it may be given longer on a less frequent schedule. It may also be stopped or decreased in frequency if side effects develop. ...Read more
Yes - RR 2.0 to 4.0:
Relative risk (rr) incr mgus 2.8, myeloma 2.9, lpl/wm 4.0, cll 2.0. From landgren et al.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/19182202
the myeloma cytogenetics are reviewed in greenberg et al. May 2013 -- http://www. Ncbi. Nlm. Nih. Gov/pubmed/23647020. ...Read more
It depends: Survival in myeloma depends on a number of factors. First, is stage. Second is chromosomal abnormalities. Some have a good prognosis, others not so good. In general we think that myeloma is not usually curable with standard therapies, but survival is getting better with our newer agents, so that living 10 years is not unusual. Cure may be possible with allogeneic bone marrow transplant. ...Read more
No: But it is one of the most effective therapies and for those who can get it, it is shown even in this era to add benefit to novel therapy. In USA we bank cells for two autos. ...Read more