Doctor insights on:
Are Hb's Levels Elevated With Beta Thalassemia Trait
My 6 yo had appt w/ hematology. Results show elevated ldh, elevated retic and increased hgb F. Is this consistent with beta thalassemia trait?
Epigenetics and drug: We know that sickle cell patients that have increased Hemoglobin F typically have less sickle cell complications. This is the basis for using Hydroxyurea in sickle cell patients. Some individuals have elevated Hemoglobin F levels due to differences in the genetic region of the beta and gamma globin genes that prevent the normal shutting-off of the gamma globin gene. This leads to increased HGB f. ...Read more
Slightly elevated beta fraction from serum protein electrophoresis. Beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen. Immunofixation normal.
Need more info.: The pattern of your blood counts over the years would be helpful. Many asian populations have hemoglobin e. Beta thal trait is also frequently seen. You need to see your hematologist to clarify what is going on and any potential treatments. Good luck. ...Read more
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, You may consult this site for information on this topic. http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9234 ...Read more
Maybe: Ice cravings has been reported as a symptom of iron deficiency anemia. Some people believe ice cravings also occur in other forms of anemia, such as thalassemia anemias. It is not known how many non-anemic persons have ice cravings, so it is unknown how likely it would be for a ice cravings to occur coincidentally with an anemia but not due to the anemia. ...Read more
Elevated rbcs (5.9), elevated hemaglobin (17.8), & elevated hematocrit (57%) low rdw. (11.0) polycythemia vera? Are these levels unsafe? Also have hbp
Genetic disorder: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3237252/ "the disorder is characterized by marked clinical variability, ranging from a mild and asymptomatic anaemia to a life-threatening disorder requiring transfusions from infancy. "...."careful tailoring of treatment is required for each patient, and that therapeutic approaches should be re-assessed over-time." not curable..Look at website-. ...Read more
Not the same.: Hemoglobin e is found in the asian population frequently and may be seen with thal trait. Thal major is a serious problem requiring much intervention, including transfusions and frequently splenectomy. Your doctor should be your guiding you. Pregnancy needs to be discussed with your doctor. ...Read moreSee 1 more doctor answer
Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read moreSee 1 more doctor answer
Electrophoresis, but: Levels of hemoglobin h and hemoglobin barts should make the distinction straightforward though there may be modifying genes that could make interpretation. The real question is the implications in planning your family and for this perhaps you would like to have genetic testing done. Any hematologist would probably enjoy helping you out. Good luck. ...Read more
Is absence of HbA in 4 month baby (only has HbF and HbA2 ) a lab diagnosis of minor beta thalassemia or major beta thalassemia ?(educational question)
Beta Thalassemia...: Great info... https://en.wikipedia.org/wiki/Beta_thalassemiaGet a more detailed answer ›
Can a female with Hb H disease marry someone with beta thalassemia trait? What are the possible results in terms of genetics percentages?
Sure: Anybody can marry anybody. Since HgbH disease involves the alpha genes and beta thal minor involves the beta genes, I would not be concerned. However, you might do well to be certain that neither partner carries the other person's trait as well masked by what's already diagnosed. Sit down with a competent clinical geneticist. ...Read more
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