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Doctor insights on: Are Femara And Norethindrone Used For Stage 4 Endometriosis

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Are femara (letrozole) and norethindrone used for stage 4 endometriosis?

Are femara (letrozole) and norethindrone used for stage 4 endometriosis?

Not very successfull: No medical treatment has ever been shown to be effective in treating stage IV endo. This stage means that there is deeply invasive endo usually between the rectum and vagina or cervix. Endo nodules are by definition deeper than 5mm, and the hormones can't penetrate well and they don't respond. You need a surgeon very experienced in complex procedures to remove the endo. ...Read more

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Dr. Michael Traub
1,197 doctors shared insights

Endometriosis (Definition)

An abnormal condition where some endometrial tissue, which is lining tissue of the uterus, is located outside the uterus. The displaced tissue, just like the tissue lining the uterus, bleeds during each menstrual cycle. Endometriosis can be very painful, and can result ...Read more


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Has anyone had success on femara (letrozole) and norethindrone for endometriosis?

Has anyone had success on femara (letrozole) and norethindrone for endometriosis?

Hormonal treatment: Femara (letrozole) inhibits the formation of estrogen within the endometriosis tissue. Aromatase inhibitors, formerly used to treat some breast cancer, have been successful in the treatment of endometriosis. Norethindrone, a Progesterone is also successful in some cases. ...Read more

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I have been diagnosed with endometriosis and have been prescribed aygestin (norethindrone) 5 mg/day. My stomach seems to be extremely hard. Help?

I have been diagnosed with endometriosis and have been prescribed aygestin (norethindrone) 5 mg/day. My stomach seems to be extremely hard. Help?

Not sure about: Aygestin (norethindrone) itself causing a hard stomach per say but some patients complain of bloating and abdominal discomfort when they start the medication. It can be self limited. Also i'd want to know more about how your endometriosis was diagnosed to better inform you, but ultimately, i would recommend talking to your doctor about this. ...Read more

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Diagnosed w/ stage 4 endometriosis in 2010. Had a laparoscopy in 2010 & a laparotomy in 2011. My ultrasounds are clear but still have pain (sometimes debilitating). Should I have another laparoscopy?

Hormone suppression: Laparoscopy and laparotomy will be sufficient to get rid of adhesions and masses in the belly, however surgery will never get rid of the route cause of your endometriosis which is the presence and production of estrogen. You would need to remove both ovaries or be placed on medications to suppress your hormones to see effects on the endometriosis. Lupron (leuprolide) injections. ...Read more

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21 years old stage 4 endometriosis, on Lupron (leuprolide) depot and still have pain. Have had 2 laparoscopic surgeries. What can I do now?

Unusual: Lupron (leuprolide) in combination with conservative surgery is usually helpful for symptomatic endometriosis. However there is another medication called danocrine that can be dosed in a variety of ways that may help as well. This was on the market well before Lupron (leuprolide) and may be worth a trial. Talk with your doctor and good luck. This is a frustrating disease. ...Read more

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My wife had endometriosis stage 4 which has been removed however there are nodules remaining which are also affecting the draining urea tube of kidney?

My wife had endometriosis stage 4 which has been removed however there are nodules remaining which are also affecting the draining urea tube of kidney?

See the attending,,,: For the condition as described, you should bring all your questions and concerns to the attending physician, instead of trying guessing game online. Best wish... ...Read more

Dr. Warren Foster
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