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Doctor insights on: Are Bone Marrow Biopsies Ever False

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Are bone marrow biopsies ever false?

Are bone marrow biopsies ever false?

Rarely: Keep in mind that there is no such thing as 100% in life or in medicine. For every test we do, there is some chance (which may be very, very small) that the result will be incorrect. ...Read more

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Dr. Lawrence Kessler
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


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Are bone marrow biopsies painful to have done?

Are bone marrow biopsies painful to have done?

It depends: If done by an experienced health care worker(doctor/nurse) the bone marrow biopsy can be tolerable(mild to moderate amount of pain). They use local anesthesia which controls 90% of the pain. So i would not worry too much about it and get it done. Just make sure that the person doing the biopsy has done more than 20 biopsies before and does them fairly frequently(>1 per month). ...Read more

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Are bone marrow biopsies and aspirations risky?

Low risk: There is always risk involved in any procedure. Some have greater risk than others. Generally speaking, bone marrow biopsies are low risk, but your hematologist would be the best person to assess whether the risk outweighs the potential benefit, which is the real question. ...Read more

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Are bone marrow biopsies done on both sides?

Are bone marrow biopsies done on both sides?

They can be: Most of the time a bone marrow biopsy and aspiration is done on one side (unilateral). For the staging of certain cancers a biopsy is done on both sides (bilateral). ...Read more

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Bone marrow Biopsy showed 2 genetic abnormality. Another bone marrow done in same center showed no abnormalities. No treatment done. Any explanation?

Bone marrow Biopsy showed 2 genetic abnormality. Another bone marrow done in same center showed no abnormalities. No treatment done. Any explanation?

Cytogenetic analysis: A bit more complicated. Not enough information to assess.Need more details on the exact type of genetic abnormality. Would be helpful to be able to view the entire genetic evaluation, complete blood count and history. Suggest that you seek a full one on one consultation. Good luck. ...Read more

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Can there be different opinion on beta 2 microglobulin and bone marrow biopsy regarding detection on multiple myeloma?

Can there be different opinion on beta 2 
microglobulin and bone marrow biopsy regarding detection on multiple myeloma?

Beta 2 Microglobulin: Is a way of following myeloma response to therapy. The problem is that it can be elevated in other conditions- including benign ones. I've seen it very high in patients with kidney dysfunction. So the leel could be different than the bone marrow, which is the only real way to prove multiple myeloma. ...Read more

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What is the difference between bone marrow aspiration n bone marrow biopsy what tests are performed in both?

What is the difference between bone marrow aspiration n bone marrow biopsy what tests are performed in both?

More info: A bone marrow aspirate is just drawing bone marrow into a syringe for evaluation. A biopsy actually removes a core of bone from the marrow cavity to check for architecture of the marrow. ...Read more

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How are bone marrow biopsy and chromosome analysis different?

There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal. Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see. ...Read more

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What would a bone marrow biopsy show? They ruled out cancer already.

What would a bone marrow biopsy show? They ruled out cancer already.

It depends,,: it depends on what it was done for. It could be to check on a precancerous condition of the blood like myelodysplastic syndrome or to see if the blood cell lines are sufficient in quantity but this is an extreme test only to be done if other tests are inconclusive or ominous. If cancer had been ruled out, there likely isn't a need for it. See your doctor to find out more info.. Good luck. ...Read more

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What tests should be done frm bone marrow biopsy n aspiration slides?

Depends on purpose: How many tests can be done from blood? Millions. How many tests can be done from a bone marrow biopsy (BMB) specimen? Many? What tests should be done? It depends on 1) purpose for performing the BMB and 2) the findings the pathologist sees on morphologic examination of the aspirate & biopsy. Tests may include stains for iron or congo red (amyloidosis) as well as flow cytometry, cytogenetics, FISH. ...Read more

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I am recently diagnosis with acute osteomyelitis accrdg to bone biopsy result but no bacteria found, MRI and indium scan was done may but negative?

I am recently diagnosis with acute osteomyelitis accrdg to bone biopsy result but no bacteria found, MRI and indium scan was done may but negative?

Suprising: Sometimes organisms are not localized in osteomyelitis because of partial treatment with antibiotics.Another reason is osteomyelitis is actually subacute and not actually acute.Patients with chronic recurrent multifocal osteomyelitis(CRMO)can get osteomyelitis in multiple sites with no bacteria that is autoimmune process.Surprising that MRI is normal. Indium is usually positive with no bacteria ...Read more

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My blood test for jak2 was negative but blood counts are still rising would you recomend bone marrow biopsy?

My blood test for jak2 was negative but blood counts are still rising would you recomend bone marrow biopsy?

Yes: Jak2 testing is supportive of certain myeloproliferative diagnsoses, but the clinical decision to pursue the bm biopsy will be driven by the extent and pace of rise and your symptoms. ...Read more

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Do doctors get non-embryonic stem cells from bone marrow?

Do doctors get non-embryonic stem cells from bone marrow?

Yes: Mostly hematopoietic (blood) cells and a few mesenchymal (mscs) can be obtained from bone marrow aspiration. Trends in most non-blood applications is to use fat tissues, which have many more mscs that bone marrow. Choice of which depends on specific conditions being treated. ...Read more

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Is bone marrow biopsy done without anesthesia?

Is bone marrow biopsy done without anesthesia?

Just for children: Young children will generally be put to sleep. The rest will at least get local anesthesia which is like novacaine over the hip. ...Read more

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I have inconsistent tests that lean toward multiple myeloma or MGUS. First xray lytic lesion; globulin series serum & urine monoclonal positive to gamma; 24 hr electopherurine neg; beginning anemia; BUN off; other small abnormals. Bone survey neg.

Need second opinion: The criteria for myeloma vs Mgus changed recently but both changes include exact percentages and size of lytic bone lesions. Your data as you summarized are not adequate and since mgus vs multiple myeloma are like dawn and day, you need to be seen and your precise numbers verified. That said, please see hemeonc in centers experienced in myeloma dx,management,and treatment. ...Read more

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Do Standard99m Tc bone scans with tracer ever reveal lytic lesions of Myeloma, or only ever osteoblastic lesions, and fracture? Having workup for MM.

Do Standard99m Tc bone scans with tracer ever reveal lytic lesions of Myeloma, or only ever osteoblastic lesions, and fracture? Having workup for MM.

Bone scan, not helpf: Bone lesions of myeloma do not show up on a Bone scan. So it is not a useful test when looking for bone lesions which can be seen more easily with MRI scan. Alternatively a CT scan can help in a localised spot and PET scan can also be useful in certain select situations. ...Read more

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Why are biopsys done? Docs have done my gall bladder biopsy reports are awaited

Why are biopsys done? Docs have done my gall bladder biopsy reports are awaited

To give info.: Biopsies help provide information as to what exactly caused the disease in you. The answer will help with treatment options. In the case of your gall bladder, you may have gall stones and figuring out what type of stones they are may help your dr. Tell you what foods you should or should not eat more of, etc. Biopsies will also let us know if there are any malignant cells. ...Read more

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Are bone marrow biopsies ever false?

Rarely: Keep in mind that there is no such thing as 100% in life or in medicine. For every test we do, there is some chance (which may be very, very small) that the result will be incorrect. ...Read more

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How do bone marrow biopsies typically work?

How do bone marrow biopsies typically work?

Biopsy...: You are typically on your stomach and lightly sedated. The area on the back of your pelvis (hip region) is injected with local anesthesia and a "large" needle is placed into the bone marrow cavity to remove a sample of the contents. ...Read more

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Are bone marrow biopsies done on both sides?

They can be: Most of the time a bone marrow biopsy and aspiration is done on one side (unilateral). For the staging of certain cancers a biopsy is done on both sides (bilateral). ...Read more

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Are bone marrow biopsies painful to have done?

It depends: If done by an experienced health care worker(doctor/nurse) the bone marrow biopsy can be tolerable(mild to moderate amount of pain). They use local anesthesia which controls 90% of the pain. So i would not worry too much about it and get it done. Just make sure that the person doing the biopsy has done more than 20 biopsies before and does them fairly frequently(>1 per month). ...Read more

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Can you tell me how do bone marrow biopsies work?

See below: Bone marrow biopsy and aspirate are done to diagnose disorders of blood and bone marrow. This site provides a short description of the procedure and indications for the procedure. http://www.nlm.nih.gov/medlineplus/ency/article/003934.htm. ...Read more

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Had a bone marrow asp and biopsy. Said abnormal female karyotype and these numbers in order. Add(14)(q22)(20). It was never explained. Could you help?

Need mor einformatio: You need to tell us about what made you go to see your doctor in the first instance and why was a bone marrow done? Unless you have some blood disorder, we can not interpret your chromosomal change(karyotype). You will be better off asking your doctor what it means now that he has given you this worry some report. ...Read more

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Is a bone marrow biopsy painful?

Yes and no: Any biopsy will be painful but in the hands of an experienced doctor and proper sedation (local novocaine) it can be a much more tolerable process. Pain killers such as tylenol (acetaminophen) afterwards for 24-58 hours can be a help too. ...Read more

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What amount is a bone marrow biopsy?

What amount is a bone marrow biopsy?

Bone marrow biopsy?: I am not clear what you are asking--do you want to know how much bone marrow is removed during a bone marrow biopsy? Generally, 5-15 cc's of marrow is removed during a bone marrow aspiration and then a 2-3 cm small piece of the bone marrow is removed for the biopsy. If you were trying to get other information please add a more detailed question. ...Read more

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Does a bone marrow biopsy cause pain?

Does a bone marrow biopsy cause pain?

Yes: A bone marrow biopsy unfortunately can be a painful procedure. It is only performed when the benefits outweigh the risks, however. ...Read more

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When do you need a bone marrow biopsy?

Blood disorders: A number of blood disorders like undiagnosed anemia, leukemia, high red cell count, low white cell or platelet count may warrant a bone marrow biopsy. See this site for more info. http://www.webmd.com/cancer/bone-marrow-aspiration-and-biopsy ...Read more

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Can getting a bone marrow biopsy hurt?

It will hurt: Even with a local anesthetic and some sedation, you can expect a fair amount of pain. Be brave and remember that it's being done to promote your improved health. ...Read more

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What is a bone marrow biopsy done for ?

Bone marrow biopsy: Hi, Bone Marrow biopsy is usually performed when a blood cell disorder is suspected, blood cell disorders are: Leukemia, aplastic anemia, multiple mylemoa and etc and some infectious processes. ...Read more

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What makes an a bone marrow biopsy abnormal?

Change in components: A bone marrow biopsy in a normal person will find the pattern of cells most often seen in a healthy person of that age.This would include red cells and their precursers (builders), white cells & precursers, platelet precursers & others. In illness, the pattern changes, and some or all may be abnormal. Tumor cells may take over every space& or few if any normal cells may be seen. ...Read more

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How painful is a bone marrow biopsy typically?

It depends: Some people have a higher pain tolerance than others. Even at the hands of the most skilled physician, a bone marrow biopsy is at least uncomfortable. ...Read more

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Why could someone require a bone-marrow biopsy?

Why could someone require a bone-marrow biopsy?

Many Indications: Bone marrow biopsy is most useful in diagnosis and staging of blood cancers (leukemia, lymphoma, multiple myeloma, etc). Also indicated for evaluating unexplained anemia, leukopenia, thrombocytopenia, pancytopenia, or unexplained elevated blood counts. It is also useful for fever of unknown origin, or as a confirmation that bone marrow transplantation is successful. ...Read more

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Where on the body is a bone marrow biopsy done?

The hip: Biopsies are taken from the upper back portion of the hip. Occasionally, if a suction aspiration is needed, a breastbone puncture can be used. ...Read more

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Are bone marrow biopsies and aspirations risky?

Low risk: There is always risk involved in any procedure. Some have greater risk than others. Generally speaking, bone marrow biopsies are low risk, but your hematologist would be the best person to assess whether the risk outweighs the potential benefit, which is the real question. ...Read more

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Does getting a bone marrow biopsy typically hurt?

Depends: If your receive conscious sedation, you will not have noticeable pain during the procedure. Afterward, you may have pain for a day or so unless there is an untoward complication. I had one and it hurt minimally for 24 hours. I had conscious sedation. ...Read more

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Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more


Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more