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Doctor insights on: Aplastic Anemia

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What sort of problem is aplastic anemia?

What sort of problem is aplastic anemia?

Aplastic anemia: Aplastic anemia is a serious problem of the blood sytem and bone marrow. The problem is that the bone marrow, where new blood cells are normally made, stops producing new cells, so you end up with low red blood cell counts, low white blood cell counts, and low platelet counts. The causes may be nutritional, cancer-related, toxin-related (eg, certain drugs), or genetic. See a hematologist.

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Dr. Steven Ginsberg
1,278 Doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more


Dr. Liawaty Ho Dr. Ho
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How does aplastic anemia and bone marrow transplant relate?

Dr. Liawaty Ho Dr. Ho
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How does aplastic anemia and bone marrow transplant relate?

Aplastic anemia: Aplastic anemia is a condition where for some unclear reason the bone marrow fails to produce normal blood cells. It could be due to underlying genetic mutation plus environmental -i.e. Drugs, chemical agent, infection, etc. Immunosupressant agent has been used to treat aplastic anemia with some response. Allogeneic bone marrow transplant will be the treatment of choice to cure the disease.

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Does aplastic anemia usually cause many symptoms?

Does aplastic anemia usually cause many symptoms?

Yes: Aplastic anemia is a failure of your bone marrow red cell production. The blood count drops, you lose energy, have trouble doing anything and if neglected the level could go so low that you cannot function and might even die. Bone marrow transplantation offers a very successful remedy. You should consult with your hematologist about this.

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What are the symptoms of aplastic anemia?

What are the symptoms of aplastic anemia?

Aplastic anemia: Aplastic anemia can make all of the blood cells low. Low red cells causes anemia. The symptoms of anemia can be fatigue, dizziness, pallor, chest pain, and shortness of breath. Low white cells make the patient susceptible to fever and a variety of infections. Low platelets make one likely to have bruising, bleeding, or petechiae (small purple freckles on the skin).

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What are the signs you get with aplastic anemia?

BM failure: Aplastic anemia is caused by bone marrow failure to produce all blood cells (affecting white cell, red blood cells as well as platelet). It can be presented with pallor, fatigue/tired, lack of energy, shortness of breath on exertion, episodes of infections, bleeding episodes, increased abdominal girth due to enlargement of spleen, etc.

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What are the tests for aplastic anemia?

What are the tests for aplastic anemia?

Many: The most basic is the cbc, which will give you hemoglobin, hematocrit, white cell count, and platelet counts. An additional important test is a reticulocyte count which gives you the production index of red cells. Your doctor can advise you further, based on your symptoms and history. Hope this helps.

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What can you do when you have aplastic anemia?

Quite a lot: Confirmed aplastic anemia is a serious condition. For severe cases treatment includes immunesuppressive drugs such as steroids, cylosporine and in younger patients (< 55 yrs old) includes donor bone marrow transplantation. In many patients long term improvements in blood counts can be obtained.

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Can Lamotrigine cause aplastic anemia?

Can Lamotrigine cause aplastic anemia?

Unfortunately, yes: Unfortunately, the very good drug for epilepsy and to some extent mood disorders, Lamotrigine can cause aplastic anemia in a very rare number of individuals. AA is present worldwide at a rate of about 4 cases per 1 million (word wide). 3.2 cases per million would be ACQUIRED such as from exposure to medication or other reasons. Usually found in younger individuals on the drug.

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How long a patient can live treated with immunosuppressive drugs for severe aplastic anemia?

An extended: Period of time. Most patients reach a new baseline which is probably not normal. Therapy is tapered slowly. We never start before 1 year or longer if response is continuing to improve.

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Love indian culture and yoga. Can I ask an indian doctor at a us hospital to use some treatments from there to heal me of aplastic anemia?

You can ask: Ask and you shall receive - except for aplastic anemia. This is a failure of your bone marrow to make red cells. It can be due to toxic insults (like benzene) but is commonly spontaneous. A few respond to high dose steroids but most require a bone marrow transplantation (not found in indian culture). This is your only hope ben obi wan kenobi.

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Can aplastic anemia be cured?

Can aplastic anemia be cured?

Possible: Aplastic anemia can be treated with immunosuppressive medications with resolution in a significant percentage of patients. Younger patients can be successfully treated with donor bone marrow transplants.

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Does folic acid prevent aplastic anemia?

Does folic acid prevent aplastic anemia?

Probably not: No evidence to the best of my knowledge. Aplastic anemia is a bone marrow failure disorder, which can be due to genetic cause, autoimmune, post-viral infection, and sometime prolonged drug use or radiation exposure.

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Can aplastic anemia be cured?

Possible: Aplastic anemia can be treated with immunosuppressive medications with resolution in a significant percentage of patients. Younger patients can be successfully treated with donor bone marrow transplants.

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Can neglis aplastic anemia be cured?

What is neglis?: Regarding aplastic anemia, yes there are good treatments for it. Standard of care for a young person with severe aplastic anemia and a matched sibling donor is an hematopoietic stem cell transplant. For those without a suitable donor, immune suppression is standard of care. If you can clarify the word "neglis" for us, we are happy to provide additional info. Cheers.

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What are the tests for aplastic anemia?

Many: The most basic is the cbc, which will give you hemoglobin, hematocrit, white cell count, and platelet counts. An additional important test is a reticulocyte count which gives you the production index of red cells. Your doctor can advise you further, based on your symptoms and history. Hope this helps.

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What medications treat aplastic anemia?

What medications treat aplastic anemia?

Many: Immune suppression with drugs like steroids, cyclosporine, and anti-thymocyte globulin (horse). Bone marrow transplantation is another important type of treatment for aplastic anemia in young people.

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What sort of problem is aplastic anemia?

Aplastic anemia: Aplastic anemia is a serious problem of the blood sytem and bone marrow. The problem is that the bone marrow, where new blood cells are normally made, stops producing new cells, so you end up with low red blood cell counts, low white blood cell counts, and low platelet counts. The causes may be nutritional, cancer-related, toxin-related (eg, certain drugs), or genetic. See a hematologist.

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Dr. Keith Stockerl-Goldstein
80 Doctors shared insights

Anemia, Aplastic (Definition)

Complete lack of blood cell reproduction. ...Read more