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Doctor insights on: Apc Gene Sequencing

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Dr. Scott McLean Dr. McLean
Clinical Genetics
31 years in practice
Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine
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What is the difference in gene sequencing tests vs gene deletion/duplication tests? Should one type of genetic test be done before the other?

What is the difference in gene sequencing tests vs gene deletion/duplication tests? Should one type of genetic test be done before the other?

Depends: Sequencing is like reading war and peace letter by letter, and deletion/duplication testing is like seeing if a chapter is completely missing or present as an extra copy. Which first? Depends on the condition. For duchenne muscular dystrophy, look for deletions first. For brca, sequence first. Your clinical geneticist can discuss the strategy with you.

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Homework: This is the last line from a long homework problem that's already all over other answer boards. It's not appropriate to bring it here, and without the rest of the problem, we can't answer it anyway.

Dr. Golder Wilson Dr. Wilson
Clinical Genetics
years in practice
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Should I screen my children for ovarian cancer genes since it seems to be so deadly? There is no history in my family.

Should I screen my children for ovarian cancer genes since it seems to be so deadly? There is no history in my family.

No: There is no simple screen for ovarian cancer susceptibility beyond the breast-ovarian cancer gene (brca) testing that costs $2600-3300. Only families with cases of ovarian or early onset (<45) breast cancer should consider this testing.

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Dr. Scott McLean Dr. McLean
Clinical Genetics
31 years in practice
Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine
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What is the difference in gene sequencing tests vs gene deletion/duplication tests? Should one type of genetic test be done before the other?

Depends: Sequencing is like reading war and peace letter by letter, and deletion/duplication testing is like seeing if a chapter is completely missing or present as an extra copy. Which first? Depends on the condition. For duchenne muscular dystrophy, look for deletions first. For brca, sequence first. Your clinical geneticist can discuss the strategy with you.

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Dr. Al Hegab Dr. Hegab
Internal Medicine - Allergy & Immunology
36 years in practice
Ain Shams University Faculty of Medicine
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Sinus infection-Gene sequencing was positive for staph epidermidis MRSE in my sinuses. I was started on Zuvox how serious is this infection?

Sinus infection-Gene sequencing was positive for staph epidermidis MRSE in my sinuses. I was started on Zuvox how serious is this infection?

MRSA sinusitis: Not uncommon, zyvox (linezolid) should take care of it, but take full prescribed dose and follow instructions, you will be fine

Dr. Robert Killian Dr. Killian
General Practice
24 years in practice
University of Utah School of Medicine
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Dr. Judy Mouchawar Dr. Mouchawar
Preventive Medicine
25 years in practice
McGill University Faculty of Medicine
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Who needs apc genetic testing?

Who needs apc genetic testing?

History of polyps: General indications for APC gene testing include patients who themselves have had 10 or more adenomas or have had a desmoid tumor, or patients who have a family member with an APC gene mutation found on genetic testing.

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Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
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Dr. Clarence Grim Dr. Grim
Internal Medicine - Endocrinology
53 years in practice
University of Missouri-Columbia School of Medicine
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Dr. Paul Pyles Dr. Pyles
Addiction Medicine
29 years in practice
The Ohio State University College of Medicine
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How much DNA is needed for nanopore sequencing?

How much DNA is needed for nanopore sequencing?

A future scientist: How much do you think is required? A single strand? A single molecule? I encourage you to find the answer. Best of wishes to your future endeavors.

Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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Can you tell me why PCR and DNA sequencing provided no results for brents pathogen.?

Can you tell me why PCR and DNA sequencing provided no results for brents pathogen.?

Homework: This is a question from a homework problem in microbiology that's already all over the answer boards. It's not appropriate to bring it here.

Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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Can you tell me why PCR and DNA sequencing provided no results for brent's pathogen.?

Homework: This is the last line from a long homework problem that's already all over other answer boards. It's not appropriate to bring it here, and without the rest of the problem, we can't answer it anyway.

Dr. James Ferguson Dr. Ferguson
Pediatrics
42 years in practice
University of Texas Medical Branch School of Medicine
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Sev. Dev. Delay -array comparative genetic hybridization (acgh) results indicate no abnormalities- would full genetic sequencing be advised (knome)?

Sev. Dev. Delay -array comparative genetic hybridization (acgh) results indicate no abnormalities- would full genetic sequencing be advised (knome)?

Not necessarily: Newer genetic tests provide incite into a variety of issues like autism & other developmental variations. Yet causation remains elusive in many cases. Sadly, an injury to the developing brain centers from an unrecognized event in an otherwise normal pregnancy is a likely cause for many. This occurs in at least half of cerebral palsy cases & dev. Delay could be produced in others, yet hard to prove.

Dr. Malinda Linn Dr. Linn
Family Medicine
10 years in practice
West Virginia School of Osteopathic Medicine
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What's the effect of genes on body shape, height and weight?

What's the effect of genes on body shape, height and weight?

Everything: Genes are entirely responsible for how we look, sound, and even taste and hear. We are a combination of things passed down through our genes from our previous generations. Most of your traits are not simply one from one parent and another from the other, but multiple possibilites of gene combinations.

Dr. Ahmad M Hadied Dr. Hadied
Orthopedic Surgery
45 years in practice
University of Damascus Faculty of Medicine
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Read that longevity might be related to personality genes. Please explain that.?

Research has focused: On genetic variations that offer a physiological advantage such as high levels of HDL ty. Cholesterol. But researchers at albert einstein college of medicine and ferkauf graduate school of psychology of yeshiva university have found that personality traits like being outgoing, optimistic, easygoing, and enjoying laughter as well as staying engaged in activities may also be part of the longevi.

Dr. Robert Killian Dr. Killian
General Practice
24 years in practice
University of Utah School of Medicine
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Can you get angina at an early age if it is in your genes?

Can you get angina at an early age if it is in your genes?

Angina: Angina is a symptom and not a condition or disease caused by genetics.

Dr. Maulik Shah Dr. Shah
Clinical Genetics
20 years in practice
Virginia Commonwealth University School of Medicine
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How much do genes determine health? Should we all check genomes?

How much do genes determine health? Should we all check genomes?

It's variable: For any given disease, there is a contribution of genetics, environment, diet and development. For rare genetic syndromes like pku, the genetic component is 100% while in type ii diabetes, genetics is about 45%. I do not recommend whole genome screening as that is often too much information to make rational decisions. I would suggest genetic susceptibility testing for specific conditions.

Dr. Clarence Grim Dr. Grim
Internal Medicine - Endocrinology
53 years in practice
University of Missouri-Columbia School of Medicine
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Dr. William Holmes Dr. Holmes
Pediatrics - Psychiatry
30 years in practice
University of Texas Medical Branch School of Medicine
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Does anyone know where autism comes from --genes?

Does anyone know where autism comes from --genes?

Multiple Factors: There are some know genetic causes of autism - the most common of these is fragile x syndrome. However, many childrent with autism have no known genetic problem. Genetic difficulties play a role, but there are other environmental factors that are suspected to play a role as well, such as environmental toxins and even the possbility of viral illnesses. Obviously, there is still much to learn.

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Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their dna sequence ...Read more


Dna (Definition)

Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. Its is comprised the nucleotide molecules which are ...Read more