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Doctor insights on: Anyone Have Problems With Long Term Wellbutrin Use

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Anyone have problems with long term wellbutrin (bupropion) use?

Anyone have problems with long term wellbutrin (bupropion) use?

Generally no: Wellbutrin (bupropion) as a long term medication to treat and prevent major depression is generally safe and does not cause any known harm. ...Read more

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Dr. Alan Ali
757 doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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My doc has prescribed me 1mg Xanax, (alprazolam) 10mg Lexapro and just added 150mg Wellbutrin XL. Is this allowed? Will this cause long term problems?!

My doc has prescribed me 1mg Xanax, (alprazolam) 10mg Lexapro and just added 150mg Wellbutrin XL.  Is this allowed? Will this cause long term problems?!

Medication effects: I understand your concern. Reflect on symptoms of Anxiety and Depression effect on your relationships, work and personal life; medication need for anxiety or depression; then discuss medication interactions, benefits and side effects; Therapy. Wellbutrin with Lexapro may increase the risk of seizures. Using Xanax (alprazolam) with Lexapro may increase dizziness, confusion, and difficulty concentrating. ...Read more

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Are there long-term effects of wellbutrin (bupropion)?

Are there long-term effects of wellbutrin (bupropion)?

Officially, none: No warnings about long-term use of wellbutrin (bupropion) have been issued. But, you have to realize that its makeup is similar to amphetamine, and is dopamine-enhancing. It can cause jitteriness, twitching, and seizures even in short-term. It can be difficult to wean from, because of irritability and anger -- not unlike nicotine withdrawal for which it is used (as zyban). Ongoing need should be reviewed. ...Read more

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What are the risks of taking wellbutrin (bupropion) and Zoloft long term? Being used to treat ADHD and OCD respectively

What are the risks of taking wellbutrin (bupropion) and Zoloft long term?  Being used to treat ADHD and OCD respectively

Not clear: There is conflicting data regarding use of antidepressants later in life and all cause mortality although there is the notion that the medications are relatively benign. There is always going to be a risk benefit analysis that is necessary in addition to the number needed to treat or a number needed to harm with any medication reflecting the capacity to do both good and bad things to patients. ...Read more

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How long should it take to stop taking wellbutrin (bupropion)?

Are you asking: How long you need to take for a specific condition or are you asking how to taper off it. What is the condition being treated? Please clarify and re-ask. Thank you. ...Read more

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How long it takes to feel better when taking wellbutrin (bupropion) xl?

2 weeks: most psychiatric medication takes about two weeks to start showing any change in individuals. ...Read more

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Please tell me how long it takes for to adjust to wellbutrin (bupropion)?

Variable: Though I have seen some people start feeling better within a few days, 2-3 weeks is a more reasonable expectation. It can take 4-6 weeks to see the full benefit. ...Read more

Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more