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Doctor insights on: Antiphospholipid Syndrome Ptt

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What is antiphospholipid syndrome?

What is antiphospholipid syndrome?

Blood clots: Antiphospholipid Syndrome (APS) can exist on its own or in association with another autoimmune condition such as lupus. It is caused by antibodies that increase the risk of blood clots. These antibodies also interfere with routine laboratory tests of blood clotting by binding to phospholipids, hence the name. The symptoms of APS can include blood clots, Raynaud's and pregnancy loss. ...Read more

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Dr. Richard Riker
221 doctors shared insights

Partial Thromboplastin Time (Definition)

The time required for clot formation in blood plasma after activation and addition of platelet particles such as phospholipids. The test called PTT or aptt is used to assess the coagulation pathways or clotting pathways in your blood. A prolonged aptt can indicate a deficiency of a component of the clotting pathways, such as factors xii, xi, ix, viii, x, v, ...Read more


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What leads to antiphospholipid syndrome?

It can be genetic: One can inherit this syndrome, or it may arise without any apparent history or cause. It is associated with multiple medical problems, including recurrent pregnancy loss. ...Read more

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Is there an aftermath of antiphospholipid syndrome?

Pregnancy outcome: Individuals with antiphospholipid syndrome may be at an increased risk of first trimester recurrent pregnancy loss. Treatments are available though to improve outcome. Make sure your OB or your fertility specialist knows so he/she can address appropriately. ...Read more

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When is the antiphospholipid syndrome treated with chemotherapy?

When is the antiphospholipid syndrome treated with chemotherapy?

Failure of other Tx: Apls (antiphospholipid antibody syndrome) if necessary can be treated first with steroids like prednisone. Sometimes just being on a blood thinner is enough to avoid blood clots that it can cause or miscarriages. Other treatments like Rituxan (rituximab) (antibody) have been used especially if low platelet counts are seen. If these initial tx fail, doctors may resort to chemo drugs like cyclophosphamide. ...Read more

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Antiphospholipid syndrome patients only between the ages of 18 - 30?

Common young/mid-age: Aps is commonly seen in the young and middle age group but can be seen in the pediatric and elderly population also. Since aps may be a part of sle (lupus), a sizable number of aps patients are young in common with the sle population. There is a female preponderance also. ...Read more

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What is the recommended INR level for someone diagnosed with Antiphospholipid Syndrome?

See details: The range should be 2-2.5 but in severe cases a level of 2.5-3 may be warranted. ...Read more

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Also, is there any other interesting information you have on antiphospholipid syndrome prengnacy disorder?

Pregnancy Morbidity: Antiphospholipid syndrome can cause significant problems with pregnancy:one or more late-term (>10 wks' gest) spontaneous abortions;one or more premature births of a physically healthy newborn at or before 34 weeks’ gestation because of severe hypertension (eclampsia); three or more unexplained, successive, spontaneous abortions before 10 weeks’ gestation. ...Read more

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Can you explain antiphospholipid syndrome?

Can you explain antiphospholipid syndrome?

Short description: It involves arterial or venous clotting or specific pregnancy complications, with laboratory evidence of anti-phospholipid antibodies. Autoantibodies, meaning produced and directed against one's self, are to plasma proteins (many:) altering normal clotting leading to thrombus (clot) and/or pregancy complications like fetal death, recurrent early pregnancy loss, eclampsia, and others. ...Read more

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What can trigger antiphospholipid syndrome ?

What can trigger antiphospholipid syndrome ?

Lupus, stress.: Systemic lupus erythematosus, chronic/acute severe stress and genetic predisposition all conspire to lead to antiphospholipid antibody syndrome. This is a very rare but devastating disorder that can have horrible perinatal outcomes with each pregnancy. Considered an autoimmune disorder, apls may have its etiological underpinnings in maternal-fetal cell trafficking, as most autoimmune conditions. ...Read more

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Can antiphospholipid syndrome (aps) be cured?

APL syndrome : Can be controlled and any complications from apl be treated . Spontaneous remission s possible over time . Needs careful vigilance and follow up by rheumatologist. ...Read more

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Dr. Victor Beshay
325 doctors shared insights

Antiphospholipid Syndrome (Definition)

Antiphospholipid antibodies are components in one's blood that can increase the risk of blood clots especially in the smallest blood vessels called capillaries. These individuals are prone to deep venous thrombosis in the leg and potentially pulmonary ...Read more