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Doctor insights on: Antiphospholipid Syndrome Lupus Anticoagulant Antibodies

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What is the definition or description of: lupus anticoagulant antibodies?

What is the definition or description of: lupus anticoagulant antibodies?

See below: Lupus anticoagulant (la) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. The disease name is a misnomer. La is actually a prothrombotic agent. The presence of la antibodies precipitates the formation of thrombi. The name derives from their properties in vitro, since in lab tests la causes an increase in clotting time. ...Read more

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Dr. Qamar Khan
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Lupus Anticoagulant Antibodies Present (Definition)

The lupus anticoagulant (la) is a screening test for anti-phospholipid antibody syndrome. (apas). Apas includes sometimes severe blood clotting of the arteries and veins. Women with apas sometimes have multiple miscarriages. Some but not all apas patients have lupus (sle). There are false positive la tests: infection and if the test is taken when patient is on an ...Read more


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What is the definition or description of: lupus anticoagulant antibodies present?

What is the definition or description of: lupus anticoagulant antibodies present?

Depends: The lupus anticoagulant (la) is a screening test for anti-phospholipid antibody syndrome. (apas). Apas includes sometimes severe blood clotting of the arteries and veins. Women with apas sometimes have multiple miscarriages. Some but not all apas patients have lupus (sle). There are false positive la tests: infection and if the test is taken when patient is on an anti-coagulant such as heparin. ...Read more

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

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If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?

If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?

Yes: The real question is should you be on long term anticoagulation. If you have had a pulmonary embolis, stroke or heart attack, the answer is usually yes andyou might need to treat simultaneously with aspirin, coumadin(rat poiison) and heparin. Sometimes a very tough disease tocontrol. ...Read more

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I miscarried twice. Doc advised me to do thrombophilia screen, anticardiopin antibody and lupus anticoagulant - what are they?

Tests for clotting: These are tests for abnormal clotting factors that, if present, may be causing you to miscarry. Someone of these causes can be treated during pregnancy. ...Read more

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I have a positive ana, positive lupus anticoagulant, 386 value for microsomal antibodies. C3 of 113, C4 of 53. A rash on face could it be lupus?

I have a positive ana, positive lupus anticoagulant, 386 value for microsomal antibodies. C3 of 113, C4 of 53.  A rash on face could it be lupus?

Yes: If the rash fits the butterfly or discoid rash or the subacute lupus skin lesion. ANA titer is usually high in lupus; you have not listed yours. The c3 and c4 are markers of disease activity and famously nonspecific. Don't try to self-diagnose; your age of 54 is a bit high for new-onset lupus though it's not impossible. ...Read more

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Dr. Boris Aronzon
504 doctors shared insights

Blood Thinners (Definition)

Agents which slow ;/or break down blood clot formation in up to 3 different ways (they do not decrease blood viscosity; thickness.) (1) some inhibit platelet function (e.g. Aspirin, clopidogrel, etc.). (2) others interfere with some of the clot forming proteins (warfarin, dabigatran, rivaroxaban, etc.), (3) others stimulate the blood clot destruction ...Read more


Anticoagulant (Definition)

Anticoagulants are any of a variety of drugs which decrease the body's ability to make or sustain blood clots. They fall, generally, into two categories. Drugs like Aspirin and clopidogrel (plavix) prevent platelets from forming the initial stages of a clot. Drugs like warfarin (coumadin) and dabigatran (pradaxa) block the later process ...Read more