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Doctor insights on: Antiphospholipid Syndrome Lupus Anticoagulant Antibodies

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

Dr. Jan Lei Iwata
10 doctors shared insights

Lupus Anticoagulant Antibodies Present (Definition)

The lupus anticoagulant (la) is a screening test for anti-phospholipid antibody syndrome. (apas). Apas includes sometimes severe blood clotting of the arteries and veins. Women with apas sometimes have multiple miscarriages. Some but not all apas patients have lupus (sle). There are false positive la tests: infection and if the test is taken when patient is on an ...Read more


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How does antiphospholipid antibody syndrome cause miscarriage?

How does antiphospholipid antibody syndrome cause miscarriage?

Autoimmune: Apl syndrome is an autoimmune disease in the same general catagory as lupus. It causes abnormal blood clotting , and attacks the body to disrupt normal funtion. Not only does it affect early pregnancy but women's spllens have been removed during a pregnancy to try to keep from pg loss. You need expert maternal-fetal doctor care before and during the pg! ...Read more

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Can aps (antiphospholipid syndrome) cause ed?

Can aps (antiphospholipid syndrome) cause ed?

Yes: The following published research article reported that 50% of the patients with aps had erectile dysfunction. http://lup.sagepub.com/content/21/3/319.abstract. ...Read more

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The antiphospholipid antibody syndrome is antibodies associated with what problem?

Miscarriage: Apa, along with lupus anti-coagulant antibody, are two antibodies that attack the areas in the cell wall of growing tissue, especially the fast-growing placental tissue of an early pregnancy. These are newly-discovered causes for recurrent miscarriage, and are usually treated with Heparin injections and Aspirin during pregnancy. ...Read more

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Is D-Dimer, hs, CRP, and/or PT/PTT elevated with antiphospholipid syndrome??

Is D-Dimer, hs, CRP, and/or PT/PTT elevated with antiphospholipid syndrome??

All could be: Depending on the spectrum of abnormalities associated with the syndrome all of these tests results could be abnormal. ...Read more

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Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read more

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Do infectious diseases trigger antiphospholipid syndrome ?

In theory: In theory if you have preexisting antiphospholipid antibodies, a major infection such sepsis can trigger these antibodies to cause clotting events. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What is antiphospolipid syndrome (hughes syndrome)?

Antiphospholipids: An autoimune disorder characterized by antibodies to certain phopholipids that predisposes to clotting problmes and pregnancy complications. A certain percentage will develop into systemic lupus. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Atenolol-induced lupus erythematosus http://www.Ncbi.Nlm.Nih.Gov/pubmed/9270530?

Atenolol-induced lupus erythematosus           http://www.Ncbi.Nlm.Nih.Gov/pubmed/9270530?

Let me explain: I read the article, this medication could induce symptoms of autoimmune disease including lupus, but lupus has no cure to date but those symptoms disappear with the treatment. That the main difference. ...Read more

Dr. Alfred Kim Dr. Kim
2 doctors agreed:
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What gene causes lupus erythematosus?

Dr. Alfred Kim Dr. Kim
2 doctors agreed:
What gene causes lupus erythematosus?

Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read more

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Can you explain the diagnosisof purpura fulmicans and lupus anticoagulant w/possible phophosilid syndrome?

No: This is a question that can be adequately answered only by complicated drawings, references to appropriate testing of several clotting factors, and analysis by a rheumatologist and a hematologist. In my patients such a discussion would take at least an hour. Hire a hematology consultant. ...Read more

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Do people with lupus have the lupus anticoagulant?

Not necessarily: Although many people with lupus have lupus anticoagulant not all do. And most people with lupus anticoagulant do not have lupus. Patients with lupus are more likely to develop the lupus anticoagulant than the general population so it is one "marker" for the disease. ...Read more

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Dr. Boris Aronzon
535 doctors shared insights

Blood Thinners (Definition)

Agents which slow ;/or break down blood clot formation in up to 3 different ways (they do not decrease blood viscosity; thickness.) (1) some inhibit platelet function (e.g. Aspirin, clopidogrel, etc.). (2) others interfere with some of the clot forming proteins (warfarin, dabigatran, rivaroxaban, etc.), (3) others stimulate the blood clot destruction ...Read more


Anticoagulant (Definition)

Anticoagulants are any of a variety of drugs which decrease the body's ability to make or sustain blood clots. They fall, generally, into two categories. Drugs like Aspirin and clopidogrel (plavix) prevent platelets from forming the initial stages of a clot. Drugs like warfarin (coumadin) and dabigatran (pradaxa) block the later process ...Read more