Doctor insights on:
Antiphospholipid Syndrome Family History Of Thrombophilia
Usually genetic in which certain parameters in the blood are lacking leading to blood clotting Over the last decade there has been many blood parameters to look at,e.g. Factor V Leiden,protein c s deficency,antiphospholipid,lupus May run in families Treatment once thrombosis occurs is ...Read more
GBS: Anyone can develop GBS, but people over 50 yrs. age are more at risk. It develops several days/weeks after having diarrhea or respiratory infection, with most common cause being a bacterium called Campylobacter, & some cases follow the Flu or Epstein Barr virus infection, and rarely after vaccination. ...Read more
What other autoimmune diseases, besides antiphospholipid syndrome, cause deep vein thrombosis & increased coagulation of blood?
It is genetic: It is caused by a rare recessive genetic mutation causing degeneration of the "telomere" part of the chromosome, leading to premature aging. Each parent of someone with the disease would have one copy of the gene and neither parent would be affected. ...Read more
Usually NOT: The mechanism of increased clotting in antiphospholipid syndrome (aps) is complex involving many levels of the clotting cascade. Although a paradoxical prolongation of the prothrombin or thromboplastin time is seen in the lab test (blood looks thinner), what happens inside the body could be the opposite - an increased risk of clotting that has nothing to do with levels of factor 8. ...Read more
Cancer patients: Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than metastases, metabolic and nutritional deficits, infections, coagulopathy or side effects of cancer treatment. They may occur before the obvious signs of a malignancy become apparent. ...Read more
Would normal CBC, metabolic panel, ESR, CRP, PT, aPTT, d-dimer make multiple myeloma or waldenstrom macroglobulinemia unlikely? Given a presumptive diagnosis of von Willebrand at age 31 with no known family history. Concerned it may be acquired form.
Not right tests: If you wish to be tested for multiple myeloma or Waldenstrom, you should have serum protein electrophoresis and immunofixation electrophoresis and if needed similar studies on urine. It is not a do it yourself diagnosis and your doctor should order the tests, if warranted. ...Read more
Miscarriage: Apa, along with lupus anti-coagulant antibody, are two antibodies that attack the areas in the cell wall of growing tissue, especially the fast-growing placental tissue of an early pregnancy. These are newly-discovered causes for recurrent miscarriage, and are usually treated with Heparin injections and Aspirin during pregnancy. ...Read more
Would a diagnosis of the VASCULAR subtype of Ehlers-Danlos syndrome likely happen before age 35? Hypermobile family with no sudden deaths.
It can: I have seen it but it sounds unlikely in you. ...Read more
Yes: Most females are born with 2 x chromosomes. Ts is a disorder resulting from missing one x chromosome or some part of it in the cells of the body. It is a disorder exclusive to females. Those with ts are born with it. Manifestations vary depending on the genetics. Small stature is one feature most girls have in common with each other. ...Read more
Pregnancy outcome: Individuals with antiphospholipid syndrome may be at an increased risk of first trimester recurrent pregnancy loss. Treatments are available though to improve outcome. Make sure your OB or your fertility specialist knows so he/she can address appropriately. ...Read moreSee 2 more doctor answers
Is there any doctor with experience of seeing patients with Cowden's syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN hamartoma tumour syndrome?
Cowden Syndrome: http://ghr.nlm.nih.gov/condition/bannayan-riley-ruvalcaba-syndrome http://ghr.nlm.nih.gov/condition/cowden-syndrome http://rarediseases.info.nih.gov/gard/6202/cowden-syndrome/resources/8 Those are fairly rare disease Perhaps the above links could assist you. Seems like University of Iowa does have expertise. ...Read more
31yrs old.2miscarraiges.1st missed 2nd anembryonic.spontaneous miscarraiges.no medical history and no family history of immune disorders.want ur guid?
Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?
Also, is there any other interesting information you have on antiphospholipid syndrome prengnacy disorder?
Pregnancy Morbidity: Antiphospholipid syndrome can cause significant problems with pregnancy:one or more late-term (>10 wks' gest) spontaneous abortions;one or more premature births of a physically healthy newborn at or before 34 weeks’ gestation because of severe hypertension (eclampsia); three or more unexplained, successive, spontaneous abortions before 10 weeks’ gestation. ...Read more
Yes. For transplant?: You've a rare condition (antiphospholipid antibody syndrome or APLAS), so regardless of whether your organs are viable for transplant, I am sure that they will be of use to the medical community that studies this disease. Whether organs can be placed in another depends on the condition that they are in at the time of "harvest". It's good let your wishes be known & thanks for being an organ donor. ...Read more
Safe but don't work: Safe but not effective can be dangerous. Antiphospholipid syndrome is rare but can cause serious problems including blood clots in the legs or lungs which may be fatal, or pregnancy complications, such as multiple early miscarriages, late miscarriage, or severe pre-eclampsia. See a hematologist if you're not trying to conceive, reproductive endocrinologist (rei) if trying, high risk OB if pregnant. ...Read moreSee 2 more doctor answers
No: Apa, along with lupus anti-coagulant antibody, are two antibodies that attack the areas in the cell wall of growing tissue, especially the fast-growing placental tissue of an early pregnancy. It is estimated that 1-5% of the american population has apa syndrome. The most worrisome effects are miscarriage and blood clot disorders. ...Read more
Increased risk: Anti-phospholipid antibody syndrome can cause growth restriction, early onset high blood pressure of pregnancy (pre-eclampsia) and blood clots. Your doctor will likely prescribe blood thinners during your pregnancy and follow the babies growth with serial ultrasounds. ...Read moreSee 2 more doctor answers
Can antiphospholipid syndrome be found in people with chronic inflammatory demyelinating polyneuropathy?
What are common neurological symptoms for seronegative antiphospholipid syndrome and once treated do these symptoms go away?
Yes and no!: First, all acla are of not the same significance, since the igm anticardiolipin ab is more likely to cause blood vessel blockage than the igg, which is worse than the iga! second, if a mini-stroke has occured, there may be complete resolution. If a major stroke has occurred then resolution will be incomlete at best. Individuals with antiphospholipid syndrome should be anticoagulated. ...Read more
I was diagnosed with antiphospholipid syndrome, but my latest blood tests came back normal. Is it possible for aps to come back again?
Yes: Antiphospholipid antibodies can come and go and then reappear. ...Read more
What autoantibody is seen the most in antiphospholipid syndrome? For example..Perhaps anticardiolipin is seen more often than the others...?
APS : The antibodies seen antiphospholipid syndrome are as follows: igg and igm anticardiolipin antibodies; lupus anticoagulant; igg and igm anti-ß2-glycoprotein i antibodies. Depending on the clinical presentation, 2 of these antibodies should be positive and the first 2 mentioned are usually measured with the third antibody measured if only one of the 1st 2 is positive. ...Read more
Can a "healthy" women pregnant with first child develop Antiphospholipid syndrome? Or does it mean usually that person had something they did not kno
Autoantibodies: Many women develop autoantibodies and are happily unaware. Most will not develop antiphospholipid antibody syndrome. If however, you have the changes on blood tests and do have abnormal clotting with symptoms, then it is likely that you had the antibodies before and would not have known. ...Read more
I have enlarged periportal lymph nodes which have remained the same size for the past 6 months. I have antiphospholipid syndrome. Could that cause it?
APLAS and lymph node: Antiphospholipid antibody syndrome can cause strokes, heart attacks, miscarriages, deep venous thromboses, pulmonary emboli, livedo reticularis, chorea, and several other things but doesn't cause lymphadenopathy per se. It is much more likely that some underlying condition is causing both the lymph nodes and the abnormal antibodies. Please see a hematologist to sort out what could be going on. ...Read more
There are a few...: The criteria for the diagnosis of aps is based upon both clinical findings(what happens to you) and laboratory findings(results of blood tests). Some of the clinical findngs are a history of blood clots; fetal death over 10 weeks; delivery under 34 weeks due to preeclampsia; 3 or more recurrent miscarriages. Since aps can adversely affect a pregnancy, you need to discuss with your physician. ...Read moreSee 1 more doctor answer
Failure of other Tx: Apls (antiphospholipid antibody syndrome) if necessary can be treated first with steroids like prednisone. Sometimes just being on a blood thinner is enough to avoid blood clots that it can cause or miscarriages. Other treatments like Rituxan (rituximab) (antibody) have been used especially if low platelet counts are seen. If these initial tx fail, doctors may resort to chemo drugs like cyclophosphamide. ...Read moreSee 1 more doctor answer
See details: The range should be 2-2.5 but in severe cases a level of 2.5-3 may be warranted. ...Read more
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