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Doctor insights on: Antiphospholipid Syndrome

Autoimmune: Apl syndrome is an autoimmune disease in the same general catagory as lupus. It causes abnormal blood clotting , and attacks the body to disrupt normal funtion. Not only does it affect early pregnancy but women's spllens have been removed during a pregnancy to try to keep from pg loss. You need expert maternal-fetal doctor care before and during the pg! ...Read more

There are a few...: The criteria for the diagnosis of aps is based upon both clinical findings(what happens to you) and laboratory findings(results of blood tests). Some of the clinical findngs are a history of blood clots; fetal death over 10 weeks; delivery under 34 weeks due to preeclampsia; 3 or more recurrent miscarriages. Since aps can adversely affect a pregnancy, you need to discuss with your physician. ...Read more

Autoimmune: Autoimmune means your body produces antibodies - cells that attack your own body. In antiphosopholipid syndrome the antibody which is made provokes blood clots (thrombosis) in both arteries and veins as well as pregnancy-related complications such as miscarriage, stillbirth, preterm delivery, or severe preeclampsia. ...Read more

Yes: Antiphospholipid antibodies can come and go and then reappear. ...Read more

Varies: Depending on the lab from 1to 14 days. ...Read more

Both.: Symptoms would lead a doctor to verify the diagnosis with a lab test. The symptoms would be bad blood clots, like a DVT or pe. ...Read more

No interaction: There is no significant interaction between these two medication and so their use should be fine together...Also, viagra (sildenafil) does not last too long and so interaction, if occurring at all, should be brief. As always, use caution whenever u must/need to use multiple meds... Have fun and good luck. ...Read more

No: Apa, along with lupus anti-coagulant antibody, are two antibodies that attack the areas in the cell wall of growing tissue, especially the fast-growing placental tissue of an early pregnancy. It is estimated that 1-5% of the american population has apa syndrome. The most worrisome effects are miscarriage and blood clot disorders. ...Read more

Unknown: Xarelto is approved by the us food & drug administration for the treatment of pulmonary embolism and deep venous thrombosis. It is approved in europe for these indications as well as in the prevention of stroke or systemic issues for patients with atrial fibrillation. As far as i can tell there is no approval for antiphospholipid antibody syndrome. I would consult with a hematologist to be sure. ...Read more

Failure of other Tx: Apls (antiphospholipid antibody syndrome) if necessary can be treated first with steroids like prednisone. Sometimes just being on a blood thinner is enough to avoid blood clots that it can cause or miscarriages. Other treatments like Rituxan (rituximab) (antibody) have been used especially if low platelet counts are seen. If these initial tx fail, doctors may resort to chemo drugs like cyclophosphamide. ...Read more

Anticoagulation.: If you get bad blood clots from antiphospholipid syndrome, treatment with Coumadin (warfarin) or another anticoagulant might be recommended. ...Read more

APL syndrome : Can be controlled and any complications from apl be treated . Spontaneous remission s possible over time . Needs careful vigilance and follow up by rheumatologist. ...Read more

Lupus, stress.: Systemic lupus erythematosus, chronic/acute severe stress and genetic predisposition all conspire to lead to antiphospholipid antibody syndrome. This is a very rare but devastating disorder that can have horrible perinatal outcomes with each pregnancy. Considered an autoimmune disorder, apls may have its etiological underpinnings in maternal-fetal cell trafficking, as most autoimmune conditions. ...Read more

Heparin: Risk for miscarriages have been related and will be significant in patient with anti phospholipids syndrome. Heparin will be needed during prenancy to reduce risk for miscarriages. It is safe to use Heparin during pregnancy. You will need to be seen by your ob/perinatologist and will likely be referred to a hematologist for your high risk pregnancy. ...Read more