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Several drugs. : Physostigmine is an inhibitor of acetylcholinesterase, increasing the availability of acetylcholine. It is used to treat myasthenia gravis, alzheimer's disease & glaucoma. Other carbamates include neostigmine, pyridostigmine, ambenonium demarcarium, & rivastigmine. Edrophonium has a similar mechanism of action. ...Read more
Potentiation: Great question! Certain causes of muscle weakness, such as those caused by organophosphates and succinyl choline, are made much worse by physostigmine, and this can lead to a respiratory crisis. If the cause of weakness is not known, this medicine might be avoided. Hope that helps! ...Read more
Please explain why is it risky to administer physostigmine to all patients presenting with muscle weakness?
Bad idea: Physostigmine is a powerful drug with many nasty side-effects. The vast majority of people presenting with muscle weakness do not have undiagnosed myasthenia gravis or anticholinergic poisoning. Give it to somebody heat exhaustion and you'll further mess up the electrolytes. Give it to some who's having a stroke and they may throw up and aspirate. Botulism / neuropathy? It can kill them. ...Read more
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Varies by response: Bupropion comes in several verstions--immediate release, twoce daily dosage form, and once-daily doseage form. Typical ranges are 200 to 450 mg a day. 450 mg is the maximum recommended doses because there is an increased risk of seizures above that dose. As with all antidepressants, the dose any individual needs varies and depends on condition being treated and side effects. ...Read moreSee 1 more doctor answer
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