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Doctor insights on: Antihistamines For Anxiety

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Dr. Heidi Fowler
3,146 doctors shared insights

Anxiety (Definition)

Anxiety is a general term for several disorders that cause nervousness, fear, apprehension, and worrying. These disorders affect how we feel and behave, and they can manifest real physical symptoms. Mild anxiety is vague and unsettling, while severe anxiety can be extremely debilitating, having a serious ...Read more


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I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t

I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t

Go to.....?: You should not mix Xanax with sedating antihistamines like diphenhydramine (Benadryl) since taking them together increases the sedative effect. If your doctor OK's it, you could use a less sedating antihistamine such as loratadine (Claritin) or fexofenadine (Allegra) with Xanax. As with any habit-forming drug, you should use Xanax sparingly at the lowest effective dose. Dr. Anne ...Read more

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Why can hydroxyzine be used for anxiety but not diphenhydramine? Both are antihistamines, one derived from the other, correct?

Not same effects: In same class of drugs as Diphenhydramine but has antagonistic effects on several receptor sites in the brain which means it works to treat anxiety, mild depression and unhealthy thought processes. ...Read more

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I am Having some mild test taking anxiety with slight nausea / tummy discomfort, I know that antihistamines are used for motion sickness. Could I try?

 I am Having some mild test taking anxiety with slight nausea / tummy discomfort, I know that antihistamines are used for motion sickness. Could I try?

Non-med options: Try learning relaxation techniques, eg. guided meditation or deep breathing (see YouTube).They lower heart rate & blood pressure, & help with physical & emotional sides of anxiety.Best if practiced regularly. Antihistamines best for anxiety (hydroxyzine is FDA approved, Benadryl (diphenhydramine) =same generation) get into the brain. They unfortunately cut off the "stay awake and alert" signal, not good for exams. ...Read more

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Does Benadryl (diphenhydramine) work for anxiety?

Does Benadryl (diphenhydramine) work for anxiety?

Time For DroolSchool: We here on the ranch call it"Benadrool"because it can shlog you out.So yes sometimes it can work for calming down. But too much turns it into Bena-DryMouthBlurredVisionKnockedOut-Dryl.So just take one capsule(25mg)or at most 50mg. It's not usually prescribed for this.There are other medications specifically for anxiety. But Benadryl (diphenhydramine) is a non-prescription medication and usually safe at proper doses ...Read more

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Is it ok to take one 25MG Benadryl (diphenhydramine) for anxiety regularly?

Is it ok to take one 25MG Benadryl (diphenhydramine) for anxiety regularly?

OK but: There are better alternatives. Talk to your doctor. Benadryl (diphenhydramine) tends to make you just drowsy . ...Read more

Dr. Alan Ali
1,147 doctors shared insights

Feeling Anxious (Definition)

different subjective and objective symptoms of anxiety. The ones usually first encountered are: rapid heart beats, increased breathing, hypervigilance, and rapid thinking. For a complete list and a thorough understanding of the how's and why's ...Read more


Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more