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Doctor insights on: Antihistamines For Anxiety

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Dr. Heidi Fowler
3,258 Doctors shared insights

Anxiety (Definition)

Anxiety is a general term for several disorders that cause nervousness, fear, apprehension, and worrying. These disorders affect how we feel and behave, and they can manifest real physical symptoms. Mild anxiety is vague and unsettling, while severe anxiety can be extremely debilitating, having a serious ...Read more


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Is Atarax the only antihistamine that's supposed to help with anxiety?

Is Atarax the only antihistamine that's supposed to help with anxiety?

Not the only one: There are a number of antihistamines that have also been helpful in treating acute anxiety. It would be best to discuss these options with your psychiatrist to find the right medication choice for you, as the sedation that often occurs with antihistamines can be quite hindering.

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I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t

I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t

Go to.....?: You should not mix Xanax with sedating antihistamines like diphenhydramine (Benadryl) since taking them together increases the sedative effect. If your doctor OK's it, you could use a less sedating antihistamine such as loratadine (Claritin) or fexofenadine (Allegra) with Xanax. As with any habit-forming drug, you should use Xanax sparingly at the lowest effective dose. Dr. Anne

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Just a thought. I suffer from burning skin sensations from anxiety. Would an antihistamine help with this sensation do you think?

Just a thought. I suffer from burning skin sensations from anxiety. Would an antihistamine help with this sensation do you think?

Depends: Usually burning skin sensations are due to nerves or is nerve pain. Best to see your doctor to see whether you have any peripheral nerve damage.

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Had anxiety bp went 160/100 pulse 120 bpm. Managed by 2 hrs. Then prescribed antihistamine for better sleep but developed boil after 2days. Is this bad?

Had anxiety bp went 160/100 pulse 120 bpm. Managed by 2 hrs. Then prescribed antihistamine for better sleep but developed boil after 2days. Is this bad?

Lots here.: The boil is likely not related to the other symptoms. The insomnia may be related to the anxiety. Yes- that BP & heart rate are elevated. What are you doing to address your anxiety? Talking therapy ranks really high. Cognitive Behavioral therapy or psychotherapy can be effective. Aim for daily exercise, 8 hours of sleep per night & good nutrition w 5 servings of veggies & 4 of fruit per day.

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Why can hydroxyzine be used for anxiety but not diphenhydramine? Both are antihistamines, one derived from the other, correct?

Not same effects: In same class of drugs as Diphenhydramine but has antagonistic effects on several receptor sites in the brain which means it works to treat anxiety, mild depression and unhealthy thought processes.

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I am Having some mild test taking anxiety with slight nausea / tummy discomfort, I know that antihistamines are used for motion sickness. Could I try?

I am Having some mild test taking anxiety with slight nausea / tummy discomfort, I know that antihistamines are used for motion sickness. Could I try?

Non-med options: Try learning relaxation techniques, eg. Guided meditation or deep breathing (see YouTube).They lower heart rate & blood pressure, & help with physical & emotional sides of anxiety.Best if practiced regularly. Antihistamines best for anxiety (hydroxyzine is FDA approved, Benadryl (diphenhydramine) =same generation) get into the brain. They unfortunately cut off the "stay awake and alert" signal, not good for exams.

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Does Benadryl (diphenhydramine) work for anxiety?

Does Benadryl (diphenhydramine) work for anxiety?

Time For DroolSchool: We here on the ranch call it"Benadrool"because it can shlog you out. So yes sometimes it can work for calming down. But too much turns it into Bena-DryMouthBlurredVisionKnockedOut-Dryl. So just take one capsule (25mg)or at most 50mg. It's not usually prescribed for this. There are other medications specifically for anxiety. But Benadryl (diphenhydramine) is a non-prescription medication and usually safe at proper doses

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Is it ok to take one 25MG Benadryl (diphenhydramine) for anxiety regularly?

Is it ok to take one 25MG Benadryl (diphenhydramine) for anxiety regularly?

OK but: There are better alternatives. Talk to your doctor. Benadryl (diphenhydramine) tends to make you just drowsy.

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Is it okay for me to take Benadryl (diphenhydramine) for some anxiety issues I am having?

Anxiety: On an as needed basis, short term, is ok. Also talk to your doctor about other options for anxiety long-term if needed.

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Is it safe to take Benadryl (diphenhydramine) every night for anxiety?

Is it safe to take Benadryl (diphenhydramine) every night for anxiety?

Benadryl (diphenhydramine): Benadryl (diphenhydramine) is not an anti-anxiety medication. People take it for its drowsiness side-effect. It will not relieve your anxiety whatsoever.

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Hello, I took one Benadryl (diphenhydramine) at 8:08 pm and I'm assuming it has kicked in but I'm really tired but full of anxiety... How much more longer will the "high" be gone?

Hello, I took one Benadryl (diphenhydramine) at 8:08 pm and I'm assuming it has kicked in but I'm really tired but full of anxiety... How much more longer will the "high" be gone?

Anxiety: I understand your concern. Benadryl can cause drowsiness and tiredness. Benadryl Allergy & Cold can cause excitability, anxiety, restlessness and insomnia. “Feeling high” can be due to Cocaine and Amphetamines. Stresses of relationship with parents and girlfriend; separation, peer pressure to use alcohol and drugs;, and to establish your Identity can cause Anxiety. See Psychiatrist for Therapy

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How can Benadryl (diphenhydramine) and Xanax differ when it comes to treating anxiety?

Very different med: Xanax and Benadryl (diphenhydramine) are two very different medications. Xanax is an anti anxiety medication approved for the treatment of anxiety. It is in the benzodiazepine class of medication so there is a risk of tolerance and withdrawal symptoms that lead to dependence. Benadryl (diphenhydramine) is an anti histamine approved for the treatment of allergy symptoms. It primarily produces drowsiness which can cover anxiety.

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If I take Benadryl (diphenhydramine) before getting on a plane, will the sedation from it help with my plane anxiety?

If I take Benadryl (diphenhydramine) before getting on a plane, will the sedation from it help with my plane anxiety?

Causes drowsiness: Might suggest this be dealt with like one handles stage fright. Try a beta-blocker like propanalol or timolol. Another choice, alprazolam, which could keep you more awake. Talk to your doc, as these approaches are all generic and relatively cheap.

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I'm having a bad anxiety attack and I want more than my usual dose of xanax. Would it be okay to take a Benadryl (diphenhydramine) or two with it?

I'm having a bad anxiety attack and I want more than my usual dose of xanax. Would it be okay to take a Benadryl (diphenhydramine) or two with it?

Consult with MD: I can answer this question for my individual patients (whom I know well). However, this is really an important question for you to address with your physician. I am afraid that by telling you how to take your meds that I would be providing medical treatment (which only your providers should do). Take care.

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. Paul Carter
634 Doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more