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Doctor insights on: Antihistamine For Itching And Rash

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Suddenly itching without rashes, after wearing new shirt. Took antihistamine but still feel the same. Severe at night cannot sleep. 2 days already.

Suddenly itching without rashes, after wearing new shirt. Took antihistamine but still feel the same. Severe at night cannot sleep. 2 days already.

Get checked: If you have already tried Benadryl (diphenhydramine) your doctor can prescribe stronger medicines depending on what you have. Good luck and avoid the new shirt as you may have developed an allergy to it. ...Read more

Dr. John Chiu
2,663 Doctors shared insights

Rash (Definition)

A skin rash is a symptom in which a person has changes on part or all of his skin, such as color changes, bumps, blisters, oozing, peeling, ...Read more


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Since 10 days, I am itching all over without any rashes. But when I scratch my skin gets damaged and red. Antihistamines only short term help no cure.

Since 10 days, I am itching all over without any rashes. But when I scratch my skin gets damaged and red. Antihistamines only short term help no cure.

Itching: Try Amlactin lotion and aveeno oatmeal bath in case dry skinbut follow up with doctor/urgent care this weekend. May be allergy to latex or other environmental/food issue. May need allergy referral ...Read more

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Itching/welts/rash everyday if I don't take antihistamines, has been happening for over 2 years, what could b wrong? Itching occurs everywhere

Itching/welts/rash everyday if I don't take antihistamines, has been happening for over 2 years, what could b wrong? Itching occurs everywhere

Chronic urticaria: You likely have CU about 30-40% of which are thought to be from an autoimmune cause. IN the absence of throat swelling and given your response to antihistamine, this is more a quality of life than a health issue. An allergy consult may be beneficial. ...Read more

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Is it normal that roseola rash worsen as days go by? What can I do for my kid? Pls help no fever she is itching and we gave antihistamine

Is it normal that roseola rash worsen as days go by? What can I do for my kid? Pls help no fever she is itching and we gave antihistamine

Cool bath may help.: Roseola rash is generally not itchy and lasts about 3 days. Itchy rash sounds more an like allergic reaction or urticaria that can come as a result of infection, so if rash doesn't clear in 3 days, please get evaluation. Continue antihistamine. Sometimes topical lotions that leave the skin feeling cool also is effective. ...Read more

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Horrible itching with no rash. Prednisone makes it stop not antihistamine. Blood work shows nothing. 5 weeks now. What is it and how stop itching?

Itching: There is a condition known as stress induced urticaria that can cause this. If you are anxious, seek help and your itching may be better. There may also be other causes that just do not cause a rash, so keep getting evaluated and worked up as needed. Best wishes. ...Read more

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What is causing my all over itching without a rash? No known allergies. Antihistamines and lotions do not help. Mild soaps, detergents, etc do but hel

What is causing my all over itching without a rash? No known allergies. Antihistamines and lotions do not help. Mild soaps, detergents, etc do but hel

Dry skin: In the winter months, the first thing I consider would be dry skin. Try using unscented soap and apply a skin moisturizer all over within 3 minutes after bathing to see it this helps. It may take a few days for the skin to calm down. If problem persists, then need to consult a dermatologist or allergist. ...Read more

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Raised lumps and extreme itching burning rash on limbs, antihistamine give some relief doc doc changed the brand of my meds. What to do now?

Raised lumps and extreme itching burning rash on limbs, antihistamine give some relief doc doc changed the brand of my meds. What to do now?

Sounds like...: Sounds like the assumption is that you're having an allergic reaction to your meds. If so, stopping it should be enough. Can take a while for your body to clear though. Continue anti-histamine. Avoid getting overheated (exertion or hot bath/shower). Can add topical steroid cream.

See doctor if not better 7-10 days after change in meds. ...Read more

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My 12 yr old son has slapped cheek rash but just on his arms. He is itching madly all over, antihistamine doesn't seem to help. What can I do to help?

My 12 yr old son has slapped cheek rash but just on his arms. He is itching madly all over, antihistamine doesn't seem to help. What can I do to help?

Fifth's Disease: Your description is of "fifth's disease." this is an exanthem (rash) caused by parvovirus b19. The facial rash (slapped cheeks) & truncal rash (lacy) last about a week. Nothing other than cool compresses or oatmeal baths help the skin, since the rash is inside the skin from an infection. Systemic antihistamines may help, but topical creams play no role in helping this condition. ...Read more

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I hav a rash on both arms and knees it itches like crazy! Had it for a very long time was told cardboard mites but cnt find them I have tried Benadryl (diphenhydramine) spray cream and pill and nothing helps!

I hav a rash on both arms and knees it itches like crazy! Had it for a very long time was told cardboard mites but cnt find them I have tried Benadryl (diphenhydramine) spray cream and pill and nothing helps!

Hard: Hard to tell without a clinical examination, but perhaps it is psoriasis or eczema? Read more about these conditions (and a classic picture on the arms, legs) and treatment options at the link below. I hope that helps a little! ...Read more

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Husband quit drinking alcohol a month ago and skin itches, keeps him up at night even when taking antihistamine. Related to quitting drinking?

Husband quit drinking alcohol a month ago and skin itches, keeps him up at night even when taking antihistamine. Related to quitting drinking?

Not expected.: Alcohol usually worsens itching unless one has drunk oneself into a semi-stupor. Not all itching is induced by histamine and thus it may not work at all. Dry skin is the most common cause for itching without a rash, consider applying a moisturizer <3 mins after bathing to see if this helps. Make sure that no new medication or supplement was introduced shortly before the onset of itching. ...Read more

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The back of my legs itch bad. When I shave it goes away. When the hair grows back it itches bad. I've had it for some time and doctors have given me antihistamines for it. One doctor said I had an allergy to my own hair.

Irritation?: Your hair is likely very curve and thus when they are long enough they may start to "tickle" or irritate your leg. This would not be helped by taking an antihistamine although a topical numbing agent or cortisone may. Since you have already found the solution, why not shave more frequently? ...Read more

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Got an allergic reaction from unknown source on my entire body, tried Benadryl (diphenhydramine), not helping. What can I try using? Just itching all over, no rashes, hives.

Got an allergic reaction from unknown source on my entire body, tried Benadryl (diphenhydramine), not helping. What can I try using? Just itching all over, no rashes, hives.

Dry skin?: Dry skin by far is the most common cause for itching without a rash. Try applying moisturizer all over within 3 mins after bathing while avoiding scented or antibacterial soap. If problem continues, see allergist or dermatologist since there are many potential causes for itching. ...Read more

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I have sulfa allergy. I have itching, burning rashes all over my body. Can I take one Claritin (24 hr) in the morning and two Benadryl (diphenhydramine) at night?

I have sulfa allergy. I have itching, burning rashes all over my body. Can I take one Claritin (24 hr) in the morning and two Benadryl (diphenhydramine) at night?

Allergic rash: You can take 4 10mg Claritin (loratadine) a day for chronic hives. Be sure it is Claritin (loratadine) plain without decongestant. Avoid Sulfite-containing foods like wine, dried fruits, radishes, potatoes, shrimp ...Read more

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Uncontrollable itching, no rash, Benadryl (diphenhydramine) for 3 days stop med this am and itch is back. What is it? How long take benadryl (diphenhydramine)? Feel miserable. Help!

Find cause: It is important to find the cause of itching. This may need a dermatologist to see you on consultation. Benadryl (diphenhydramine) is a temp relief medicine, it does not cure the problem. Make sure your skin is well moisturized as dry skin can be the cause especially with all the heating going on in the house during cold months. ...Read more

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Itching all over no rash for three weeks. Tried Benadryl (diphenhydramine) but it don't work it gets worse at night?

Itching all over no rash for three weeks. Tried Benadryl (diphenhydramine) but it don't work it gets worse at night?

Need Evaluation: You should be seen by your primary care doctor. You could have a number of different issues- thryoid, liver, kidney, etc. Blood work and evaluation may be mandatory! ...Read more

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Itching all over no rash for three weeks. Tried Benadryl (diphenhydramine) but it don't work it gets worse at night?

Itching all over no rash for three weeks. Tried Benadryl (diphenhydramine) but it don't work it gets worse at night?

Needs an evaluation: There are a lot of reasons to be very itchy, from scabies infestation to eczema to liver or kidney disease. Each one needs different treatments so you need to get evaluated by your physician asap. In the meantime, use gentle cleansers on the skin and moisturize at least twice daily to keep the skin calm. And try your best not to scratch! ...Read more

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My 2.5 year old son has a heat rash. Would childrens benadryl be helpful for him to alleviate the rash and itching?

My 2.5 year old son has a heat rash. Would childrens benadryl be helpful for him to alleviate the rash and itching?

No: According to the drug manufacturers of Benadryl it is not recommended in children under six years old when the medication is purchased over the counter at the drugstore or grocery.
Pediatricians do use the medication based on weight dosing guidelines.
For safety check with your doctor. ...Read more

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Does Benadryl (diphenhydramine) help contact dermatitis rash go away or does be Benadryl (diphenhydramine) only help with itching not the swelling?

Does Benadryl (diphenhydramine) help contact dermatitis rash go away or does be Benadryl (diphenhydramine) only help with itching not the swelling?

Contact dermatitis: Benadryl (diphenhydramine) and other antihistamines treat reactions that are cause by histamine release, like hives (urticaria). Contact dermatitis is inflammation driven by cells of the immune system called lymphocytes. Taking Benadryl (diphenhydramine) for contact dermatitis will make you sleepy but doesn't reduce itch or inflammation. Contact dermatitis responds to topical and if severe enough, oral steroids. ...Read more

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Uncontrollable itching all over body. No rash. Took Benadryl (diphenhydramine) and warm bad. Ate white cheddar puffs. 4hrs ago. Somewhat still itching but easier.?

Uncontrollable itching all over body. No rash. Took Benadryl (diphenhydramine) and warm bad. Ate white cheddar puffs. 4hrs ago. Somewhat still itching but easier.?

No rash?: Itching without rash is somewhat unusual for an allergic reaction to a food. Write down everything you have eaten in the past 12 to 24 hours. It may be something you don't suspect. If it occurs again, you can begin to narrow down the possibilities, if the itching is from an allergic cause. ...Read more

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Anaphylaxis to med yesterday, used epi/ER. Feel better, swelling/rash/fast heartbt etc. Are gone except mild itching. Should I use benadryl (diphenhydramine)? Or?

Benadryl (diphenhydramine) is fine but: cetirizine or loratadine, have more convinient dosing though and should be non-sedating, all are OTC, what I advise you more, is to stay at home for at least 24 hrs after the attack, keep epipen (epinephrine) handy, continue using the any antihistamine regulary, use as well ranitidine regulary, flag the medicine that caused it and visit an Allergist, check aaaai. Org or acaai. Org to see allergists where you live ...Read more

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Intense body itching x3 days, no rash. No changes in lotion, soap, conditioner, dryer sheets, etc. Benadryl (diphenhydramine) lasts 2-3 hrs, atarax lasts 4. Ideas!?

Intense body itching x3 days, no rash. No changes in lotion, soap, conditioner, dryer sheets, etc. Benadryl (diphenhydramine) lasts 2-3 hrs, atarax lasts 4. Ideas!?

Pruritus: Moisturizer your skin regularly, especially after showring, don't use very hot water. Eliminate all otc supplements, if the problem persists see an allergist. ...Read more

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"i have a rash and it will not stop itching I went to the e.r last night and they prescribed me prednisone and told me to take Benadryl (diphenhydramine) I am 20 weeks?

"i have a rash and it will not stop itching I went to the e.r last night and they prescribed me prednisone and told me to take Benadryl (diphenhydramine) I am 20 weeks?

See derm: Pregnancy alone can be associated with skin rash sometimes severe. A short-course of prednisone is the usual treatment. Benadryl (diphenhydramine) does help by making you a little drowsy and probably not from its antihistamine effect. If the problem continues, consult a dermatologist. ...Read more

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My hubby has severe itching all day/night. Scabies test neg. CBC normal. Going on 8 weeks. Hydroxyzine & Benadryl (diphenhydramine) no help. No other sympts. Has rash

My hubby has severe itching all day/night. Scabies test neg. CBC normal. Going on 8 weeks. Hydroxyzine & Benadryl (diphenhydramine) no help. No other sympts. Has rash

See derm: See dermatologist since there are many causes for itching. In the meanwhile, be sure to apply a moisturizer immediately after bathing to see if this helps since dry skin is by far the most common cause for itching. On the other hand, the rash needs to be examined even though it may come from repeated scratching. ...Read more

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I have had extreme itching all over my body with no rash at all just scratch marks. I have been taking Benadryl (diphenhydramine) and anti itch cream and doesn't help?

Pruritis: See your primary care physician for labwork and exam. There are conditions such as liver problems that can cause itching without a rash. Try claritin and zantac (ranitidine) together, if not allergic and no contraindications. See your doctor soon. It must be miserable. Try and stop the itch-scatch cycle by trimming fingernails and wearing socks or gloves at night. ...Read more

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I have generalized itching all over that comes and goes (no rash). I have been on azathioprine for years for crohn's. I have tried Benadryl (diphenhydramine) & lotion. Could the itching be related to the azathioprine?

Simple Carb. Diet: Please google for simple carbohydrate diet & follow it x 1 month.& then stop azathioprine to clinch the diagnosis of itching by aza.
Call your GI doc about this. ...Read more

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35 weeks pregnant itching from head to toe. Took shower, and 2 benadryl (diphenhydramine). Very aggravating. No rash?

35 weeks pregnant itching from head to toe. Took shower, and 2 benadryl (diphenhydramine). Very aggravating. No rash?

Cholestasis?: This can give rise to intense generalized itching and is due to the gall bladder emptying slowly. Your doctor may consider running a test to rule in rule out this diagnosis. ...Read more

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Generalized itching for five months. No rash, normal blood work no allergies found. Zyrtec. Benadryl, (diphenhydramine) and hydroxyzine don't work what's wrong with me?

Generalized itching for five months. No rash, normal blood work no allergies found. Zyrtec. Benadryl, (diphenhydramine) and hydroxyzine don't work what's wrong with me?

Very difficult: You omitted details. Exactly which blood tests? May be serious. Best see a dermatologist. Never due to laundry products. Not due to food. Only sedation or placebo effect with any antihistamine. Severe, generalized itch with no rash is very difficult to define or treat. Sometimes we find an underlying disease which needs attention. You need a professional, not a DR without experience with this. ...Read more

Dr. Cornelia Franz
1,059 Doctors shared insights

Rash (Definition)

A rash is a change to skin condition which can affect color, appearance, or texture. It may or may not ...Read more


Dr. Paul Carter
643 Doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more