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Doctor insights on: Anticholinergic Effects Of Antihistamines

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Newer antihistamines are not anticholinergic. So why are side effects like constipation often reported for claritin (loratadine) for example?

Newer antihistamines are not anticholinergic. So why are side effects like constipation often reported for claritin (loratadine) for example?

Less anticholinergic: Newer generation antihistamines like Claritin (loratadine) still have anticholinergic properties, but to a much lower degree compared with first-gen. Some patients remain highly sensitive to associated side effects. ...Read more

Anticholinergic (Definition)

Most drugs have some anticholinergic qualities, which means they interfere with the normal function ...Read more


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Why bilateral armpit rash after swimming 1 min? I cannot use antihistamines 'cos severe anticholinergic effects (dysphonia, dry mucose). Montelukast.

Why bilateral armpit rash after swimming 1 min? I cannot use antihistamines 'cos severe anticholinergic effects (dysphonia, dry mucose). Montelukast.

Topical creme: There are multiple topical compounded cremes and ointments containing antihistamines which can be applied locally but not get absorbed systemically. Ask your doctor to prescribe some. ...Read more

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Safe for a person who takes haldol (haloperidol) + anticholinergic / antihistamine do physical activity at the gym?

Yes: The short answer is yes. I might add, that taking alot of anticholinergic medication, i.e. Cogentin/benztropine or artane/trihexylphenadil-can decrease one's ability to perspire, or sweat. As sweating is the body's natural mechanism to cool off, a concern might be that a person could become overheated. Be sure and drink lots of water and be careful not to become overheated. See: hyperpyrexia. ...Read more

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Does anticholinergic or antihistamine alone relieve bronchoconstriction in asthma? Will doctors prescribe one or another or both with beta 2 agonist?

Does anticholinergic or antihistamine alone relieve bronchoconstriction in asthma? Will doctors prescribe one or another or both with beta 2 agonist?

Anticholinergic: Anticholinergic but not the usual doses of antihistamine relieves bronchoconstriction in some people. It may be used as a combination with a beta 2 agonist as in the case of combivent (albuterol and ipratropium). However persistent asthma should be treated with a controller drug such as inhaled steroid and/or a leukotriene blocker. Using just beta agonist alone on a regular basis may actually make your asthma worse. ...Read more

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Will benadryl (diphenhydramine) have an effect on a methacholine challenge since it's an anticholinergic drug?

Will benadryl (diphenhydramine) have an effect on a methacholine challenge since it's an anticholinergic drug?

Possibly : To get the best indication of bronchial hyper reactivity, you should not take any antihistamines for 3 to 7 days before the challenge. Unless, of course, the point is to see if Benadryl (diphenhydramine) will diminish the reactivity. That's why you need to discuss such questions with the physician who ordered the test. ...Read more

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Do anticholinergic medications like Benadryl (diphenhydramine) have a link with mild cognitive impairment?

Do anticholinergic medications like Benadryl (diphenhydramine) have a link with mild cognitive impairment?

No: Unlikely; Benadryl (diphenhydramine) has drowsy effects, but clears out after few hours. Interestingly can cause paradoxical stimulation as a side effect. A chronic mild cognitive impairment could be something else. ...Read more

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What are the side effects of using antihistamines?

What are the side effects of using antihistamines?

Few: There are no long term adverse effects from using antihistamines. Short term sides effects are typically from older antihistamines such as Benadryl (diphenhydramine) that can cause drowsiness and delayed reaction time. New generation antihistamines such as claritin, clarinex, zyrtec, xyzal and Allegra are generally very well tolerated. No dependence and few if any drug interactions. ...Read more

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I wish to know what are the side effects of antihistamines?

I wish to know what are the side effects of antihistamines?

Tiredness : Mostly they cause tiredness but if you have a prostate problem, be careful don't drink and take benedry and don't drive or operate heavy machinery! ...Read more

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How can we reduce or eliminate the side effects of antihistamines?

How can we reduce or eliminate the side effects of antihistamines?

Try different brands: The side effects of antihistamines (dry mouth, tiredness. Etc) vary from drug to drug. For example Benadryl (diphenhydramine) OTC is more likely to make you sleepy (in fact for some it's a safe sleeping pill) whereas the more recent additions to the OTC antihistamine group (eg Claritin) have less sleepiness (but more dry mouth) Each Person reacts differently to these drugs Try some
Hope this helps DR Z ...Read more

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What are the side effects of antihistamines and what can we do about each?

What are the side effects of antihistamines and what can we do about each?

3rd generation AH: Older antihistamines (AH) like Benadryl, (diphenhydramine) Atarax, Periactin caused drowsiness and dry mouth in at least 30% of the people. Weight gain in another potential side effect.
Newer antihistamines like Zyrtec, Xyzal causes drowsiness in about 10% of the people 3rd generation AH like Allegra and Claritin are not expected to cause drowsiness in 95% of the people. ...Read more

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Which effects does antihistamines have on the body?

Many: New generation antihistamines (claritin, zyrtec, (cetirizine) allegra) will decrease itching, runny nose and sneezing associated with allergies. They also help with itching and hives. Older antihistamines do the same, but may also cause side effects like dry mouth, dry eyes, GI upset, fatigue, sleepiness, impaired reaction time, and increased appetite. ...Read more

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Will taking antihistamines at bedtime reduce its effects the second day?

Antihistamines: At night should not have any effect on how well they work the next day. People don't get desensitized to antihistamines, though a lot think they do. If you are taking Benadryl (diphenhydramine) at bedtime, don't expect it to take care of you the next day though, as it is a short acting medication. ...Read more

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Is antihistamine bad for asthma.if not what is the safest antihistamine to take with minimum side effects?

No: Antihistamines are not bad to take if you have asthma, however if you're using them to treat asthma symptoms this is not appropriate. Antihistamines are for itchy, sneezy symptoms secondary to allergies. Asthma medications include albuterol and daily inhaled steroids. Non-sedating antihistamines like Claritn, Zyrtec, and Allegra (fexofenadine) have relatively equal efficacy and safety profiles ...Read more

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What are long term side effects of diphenhydramine antihistamines and do they lose effectiveness over time? K

Minimal: Diphenhydramine is the active ingredient in Benadryl (diphenhydramine) and has been around for a very long time. Like most antihistamines, there is not believed to be long term side effects. Losing effectiveness is less well studied, but with ongoing use there could be some development of tolerance or it could be that you are still being exposed to an allergen and that is why symptoms are not controlled. ...Read more

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Can a non drowsy antihistamine that had no side effects that I've noticed hurt you if u take 2 pills in 24hrs instead of 2?

Can a non drowsy antihistamine that had no side effects that I've noticed hurt you if u take 2 pills in 24hrs instead of 2?

No: Which antihistamine? Why using it? Sometimes, for chronic urticaria, cetirizine [Zyrtec] is dosed at 3 a day. The official dose of these is 1 a day. Allegra and claritin are also sometimes used at double or triple dose. It is best if you consult a Dr before you take doses higher than usual. ...Read more

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Is it possible to get "rebound" side effects from stopping an antihistamine? I've been taking one for 5 months, and have sinus problems since stopping

You probably need it: Rebound to cessation of antihistamines would be unusual,. If you took a combination antihistamine/decongestant, it would be more common. However, you had been taking an antihistamine for 5 months. Had you taken it for a nasal problem? My hunch is that your nasal/sinus problem, for which you had taken the antihistamine in the first place, recurred the moment you stopped it. ...Read more

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I am about to take an antihistamine for the first time but my friends tell me to use it before bedtime. Will I still feel the effects the next day?

Depends on the med: Some antihistamines are more sedating than others. Medications like Benadryl (diphenhydramine) can definitely cause sedation. Newer antihistamines like Allegra and Claritin are non-sedating and Zyrtec is sedating in roughly 10-20% of patients. ...Read more

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Is there any side effects when you take antihistamines for a longer period than a month?

Unlikely: Antihistamines are generally safe to take for prolonged periods of time, as long as you're taking the proper dose. These medicines are notorious for causing drowsiness, although some over the counter antihistamines are non-drowsy. ...Read more

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I understand that one cannot become addicted to antihistamines, however, can't people become addicted to the sedating effects of drugs?

Tolerance: You become tolerant to the sedative effect of first generation antihistamines and with time you will no longer feel sedated from them. If you are using then as a sleep aid, will you need more with time to achieve the same level of sedation. It is not an addiction, it is tolerance to the medication. ...Read more

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Are anti-histamines considered anti-cholinergics? What about ventolin for asthma, is that anti-cholinergic?

Are anti-histamines considered anti-cholinergics? What about ventolin for asthma, is that anti-cholinergic?

Neither are, really.: Ventolin is albuterol... A sympathetic nervous system stimulant that causes airways to dilate. Anti-histamines are not anticholinergic, per se, but in high doses or in the elderly they can cause some same neurological symptoms as anticholinergics. Newer antihistamines are not a problem though, because they penetrate the brain less well — which is why they don't make you drowsy. ...Read more

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Is there any side effects when you take antihistamines like atarax (hydroxyzine) for a longer period?

Is there any side effects when you take antihistamines like atarax (hydroxyzine) for a longer period?

No: Even though it is an effective sedative, hypnotic, analgesic, and tranquilizer, it shares almost none of the abuse, dependence, addiction, and toxicity potential of other drugs used for the same range of therapeutic reasons. ...Read more

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Long-term side effects from taking bilastine 20mg 1x per day (antihistamine) for chronic rhinitis? Need it to help dry up post-nasal drip.

Probably safe: There is no major side effect from taking this type of antihistamine long term (not yet approved in US) but a small percentage of people may experience drowsiness and weight gain. It may potentially impact memory function among people with memory impairment. ...Read more

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Allergic reactions include runny nose and watery eyes. Can antihistamine drugs help prevent or decrease the effects of an allergic reaction?

Allergic reactions include runny nose and watery eyes. Can antihistamine drugs help prevent or decrease the effects of an allergic reaction?

Yes: Antihistamines are very successful at decreasing symptoms of runny nose and itchy eyes. There are both aver the counter and prescription antihistamines available. ...Read more

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I gave expired antihistamine syrup to my 30 months old son incidentally... Is it dangerous? What s the side effect on him?

I gave expired antihistamine syrup to my 30 months old son incidentally... Is it dangerous? What s the side effect on him?

Expired drugs: There should be no side effects as expiration is usually based on loss of drug effectiveness. Drug companies err on the side of shortening times to expiration. Actually many drugs are effective long after expiration dates. Expired drugs are commonly used effectively by volunteer organizations when no other drugs are available. Relax! ...Read more

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What are the common uses of antihistamine?

Antihistamine 4 itch: Antihistamines (ah) block histamine receptors and stop histamine from causing itching and swelling. They are mainly used to treat allergies and hives. Some are sedating; those are used as sleep aids. Many otc sleep meds contain Diphenhydramine (benadryl). ...Read more

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Is Flixonase an antihistamine?

Steroid Nasal Spray: Flixonase or Flonase (fluticasone proprionate) is a steroid nasal spray commonly used to treat allergic rhinitis by decreasing the allergic inflammation in the nasal mucosa. It is not an antihistamine. ...Read more

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Is there an antihistamine cream?

Yes, but avoid: Benadryl (diphenhydramine) cream is available. While some people find temporary relief for insect bites with this, in general it is not very effective compared to other antihistamines taken as pills or tabs. For generalized rash, it really doesn't make sense. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. Paul Carter
648 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more