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Doctor insights on: Anticardiolipin Antibodies

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Dr. Lonnie Smith
25 doctors shared insights

Anticardiolipin Antibodies (Overview)

Anti-cardiolipin antibodies (aca) are antibodies directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, and lupus. They are a form of anti-mitochondrial antibody. Aca can be classified as either igm, igg or IgA and they can be β2-glycoprotein dependent or independent. Anti-phospholipid antibodies can either be lupus anticoagulants or the aca.


Dr. Lonnie Smith
25 doctors shared insights

Anticardiolipin Antibodies (Overview)

Anti-cardiolipin antibodies (aca) are antibodies directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, and lupus. They are a form of anti-mitochondrial antibody. Aca can be classified as either igm, igg or IgA and they can be β2-glycoprotein dependent or independent. Anti-phospholipid antibodies can either be lupus anticoagulants or the aca.


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Is it dangerous to have elevated anticardiolipin antibodies?

Is it dangerous to have elevated anticardiolipin antibodies?

It depends: Just having those antibodies may be harmless. However, they can be associated with certain diseases; cause thrombosis (occlusion) of blood vessels, reduce the number of platelets (the cells in the blood that are crucial for clotting) and bleeding in the skin. Most depends on how high the level of those antibodies is in your system. ...Read more

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Hepatocellular disease, seizures, low blood count, anticardiolipin antibodies, arthritis, rash on hands and numbness in legs. What does this all mean?

Hepatocellular disease, seizures, low blood count, anticardiolipin antibodies, arthritis, rash on hands and numbness in legs. What does this all mean?

Auto-immune disorder: You have described features of auto-immune disorder. For example, a person with lupus could have all these features. You need evaluation and treatment by a physician in consultation with specialists in more than one field. ...Read more

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I have antiphospholipid syndrome(aps), with anticardiolipin antibodies igg/gpl extremely high. Others are normal. What problems arise with a high igl?

I have antiphospholipid syndrome(aps), with anticardiolipin antibodies igg/gpl extremely high. Others are normal. What problems arise with a high igl?

Antiphospholipid syn: Antiphospholipid syndrome (aps) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. Some patients with aps have no evidence of any definable associated disease, while, in other patients, aps occurs in association with sle or another rheumatic or autoimmune disorder. Traditionally, these have been referred to as primary or secondary aps, respectivel. ...Read more

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What are the cuases of elevated anticardiolipin antibodies?

What are the cuases of elevated anticardiolipin antibodies?

Auto-immunity: Anticardiolipin antibodies are commonly present in systemic lupus and related disorders. These antibodies are also present due to syphilis. See this site for more info. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc95774/. ...Read more

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Does anybody know about elevated anticardiolipin antibodies?

Auto-antbody: Anti-cardiolipin antibodies are seen in two main conditions, (1) auto-immune disease like systemic lupus, anti-phopholipid syndrome and (2) syphilis. ...Read more

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What happens if you have elevated anticardiolipin antibodies?

What happens if you have elevated anticardiolipin antibodies?

Depends: Antiphospholipid syndrome(aps) is an autoimmune disorder characterized by thromboses, complications of pregnancy, and certain laboratory abnormalities. Anti-cardiolipin of the IgA isotype are not part of the laboratory criteria for aps due to lack of specificity.Consult with your doctor regarding which type of antibody was tested and significance in your clinical situation. ...Read more

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What is the definition or description of: anticardiolipin antibodies?

Mitochondrial factor: Cardiolipin is the equivalent of a mitochondrial factor, and so anticardiolipin antibodies are considered to be anti-mitochondrial antibiodies. They are also found in various diseases (such as syphilis, antiphospholipid syndrome, behçet's syndrome, systemic lupus erythematosus). They can be seen in association with spontaneous abortions too. ...Read more

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Is it dangerous to have elevated anticardiolipin antibodies?

It depends: Just having those antibodies may be harmless. However, they can be associated with certain diseases; cause thrombosis (occlusion) of blood vessels, reduce the number of platelets (the cells in the blood that are crucial for clotting) and bleeding in the skin. Most depends on how high the level of those antibodies is in your system. ...Read more

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Do you have lupus if you have anticardiolipin antibodies? What else do you look for with this?

Do you have lupus if you have anticardiolipin antibodies? What else do you look for with this?

Not necessarily: Antiphospholipid antibodies can occur where there is no underlying disease or can be associated with lupus, rheumatoid arthritis and other disorders. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more