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Doctor insights on: Anticardiolipin Ab Ig M Qn

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Dr. Gregory Lanza
823 Doctors shared insights

Immunoglobulin M (Definition)

There are 5 classes of immune proteins: igg, iga, igm, ige and igd. Igm fights infection. If you produce too little then infections may occur and you have hypogammaglobulinemia. If you have too much you ...Read more


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Anticardiolipin IgM elevated, what does it mean?

Anticardiolipin IgM elevated, what does it mean?

Antiphospholipids: Autoimmune antibodies can be formed against natural (normal) cell surface proteins. When this happens, adverse effects can occur. Anti-cardiolipin antibodies have been associated with abnormal blood clotting events and recurrent spontaneous miscarrages. See a hematology specialist for advice on this problem. ...Read more

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My anticardiolipin IgM is rising, now at 93.0 should I be concerned?

My anticardiolipin IgM is rising, now at 93.0 should I be concerned?

Anticardiolipin Ab: The primary consequence of the antiphospholipid antibody is non-inflammatory thromboembolic (clotting) disease. Virtually all venous and arterial systems have been cited, including large, medium, and small vessels. It could simply mean that the underlying disease process (lupus) is not being treated or controlled. ...Read more

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Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own? LA Positive but beta glycoprotein & other antibodies neg

Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own? LA Positive but beta glycoprotein & other antibodies neg

Higher future risk: The cause of an elevated aCL without other diseases is unknown. That said, 50% of people with + lupus anticoagulant have or will have SLE. Presumably, manifestations require the aCL plus another problem - infection, one of a number of drugs, pregnancy, BC pills, etc. The significance is the higher than normal risk in the face of future immunological injury ...Read more

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Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?

See below: There are certain criteria that must be met in order for one to have aps. One of which is that one must have some type of thrombotic event. Antibodies alone do not make the diagnosis. Without knowing full details regarding your case, it is difficult to say whether you do or not. ...Read more

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My anticardiolipins IgM has come back high in the last two years ranging from 113 to 53 recently what does this mean? My ANA & Other antibodies Neg.

My anticardiolipins IgM has come back high in the last two years ranging from 113 to 53 recently what does this mean? My ANA & Other antibodies Neg.

Anticardiolipins: Usually that only causes a problem for the fetus. Are you thinking of getting pregnant in the near future? If not, then I would just forget about it for the moment. ...Read more

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My anti-cardiolipin IgM was in nov 133 / 82 in jan & in feb it came down to 9.38. Should I still be referred & do I need it checked again if so when?

My anti-cardiolipin IgM was in nov 133 / 82 in jan & in feb it came down to 9.38. Should I still be referred & do I need it checked again if so when?

Ask first: Ask first why the test is being run. If there is a suspected blood clotting disorder, yes, you should see a specialist such as a hematologist. If there is an autoimmune disease process, you should see a rheumatologist. If neither of these apply, then question why the test is being run. ...Read more

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My anti-cardiolipin IgM 133u/ml (nov), 82u/ml (feb). Who do I need to see with regards to this? What speciality.

My anti-cardiolipin IgM 133u/ml (nov), 82u/ml (feb). Who do I need to see with regards to this? What speciality.

See details: If this is the only issue, see a hematologist. If it is related to lupus or another connective tissue disorder, see a rheumatologist. ...Read more

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My anti-cardiolipin IgM was checked to rule out mctd. It was in nov 133 / 82 in jan & in feb it came down to 9.38. Does it need to be tested again?

My anti-cardiolipin IgM was checked to rule out mctd. It was in nov 133 / 82 in jan & in feb it came down to 9.38. Does it need to be tested again?

See details: Anticardiolipins never rule in or rule out mctd. They are used to diagnosis specific clotting disorders that can be associated with connective tissue disorders. The levels of anticardiolipins vary up and down and in your case they should be checked once or twice a year, not every month or two. I would urge taking an 81 mg asa daily as protection if your doctor agrees. ...Read more

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My anti-cardiolipin IgM was in nov 133u/ml, 31st jan 82u/ml and on the 4th feb it came down to 9.38 mpl. Can it drop that much in 5 days? Is it error?

My anti-cardiolipin IgM was in nov 133u/ml, 31st jan 82u/ml and on the 4th feb it came down to 9.38 mpl. Can it drop that much in 5 days? Is it error?

Yes: Igm response is an acute response to an infection or inflammation and can drop very quickly if the process has subsided or controlled by medication. ...Read more

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Anti-cardiolipin IgM was checked as part of tests for mctd. It was 133 nov / 82 in jan & in feb it was 9.38. Gp says there no needs to refer or treat?

Anti-cardiolipin IgM was checked as part of tests for mctd. It was 133 nov / 82 in jan & in feb it was 9.38. Gp says there no needs to refer or treat?

? Referral: To have anti-phospholipid antibody syndrome you need to have 2 positive tests at least 3 months apart. Transient elevations are common and not risky. It's unusual that the first test was so high and it did not persist. If you still have other mctd symptoms you should see a rheumatologist. ...Read more

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My anti-cardiolipin IgM was in nov 133u/ml, jan 82u/ml and on the feb it came down to 9.38 mpl. Pt 13.8 ptt 31.2 hypermobility of the joints. Normal?

My anti-cardiolipin IgM was in nov 133u/ml, jan 82u/ml and on the feb it came down to 9.38 mpl. Pt 13.8 ptt 31.2 hypermobility of the joints. Normal?

Maybe: Having an anticardiolipid become positive is always concerning. I am glad it was repeated and came down. With that said an evaluation from a hematologist would be a good next step, as there are many other things to consider that go far beyond the scope of this forum. ...Read more

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I have a swollen painful leg. I had a d-dimer 300, globulin 36 & neutrophil 6.44. Recent test anti-cardiolipin IgM was in 82u/ml pt 13.8 is it ok?

I have a swollen painful leg. I had a d-dimer 300, globulin 36 & neutrophil 6.44. Recent test anti-cardiolipin IgM was in 82u/ml pt 13.8 is it ok?

Cause of leg pain: Superficial phlebitis can cause this as well as non thrombotic problems such as cellulitis, infections, connective tissue problems etc. See a doc to separate out the confusion. There is always a reason for a painful leg. ...Read more

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In nov my anti-cardiolipin IgM 133u/ml in feb it was 82u/ml. My ANA and celiac screen has come back negative but IgA 4.86g/l CRP 12.86, mchc 310g/l.

In nov my anti-cardiolipin IgM 133u/ml in feb it was 82u/ml. My ANA and celiac screen has come back negative but IgA 4.86g/l CRP 12.86, mchc 310g/l.

See details: Anticardiolipin antibodies tend to rise and fall but both values are significantly elevated. The igg fraction is more likely to be associated with clotting issues. ...Read more

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Tested for anti cardiolipin IgM is negative (0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?

Tested for anti cardiolipin IgM is negative (0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?

Not sure: I am not sure I understand the question. I suspect you are being evaluated for a blood clotting disorder and you have an elevated anticardiolipin IgG. One test however does not make the diagnosis of anti-phospholipid syndrome. ...Read more

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What is hepatitis b core ab IgM test?

What is hepatitis b core ab IgM test?

See below: Presence of IgM hepatitis b core antibody indicates an acute (current) or recent hepatitis b infection. ...Read more

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Beta-2 glycoprotein I ab, IgM 48 high. What does this mean?

Beta-2 glycoprotein I ab, IgM 48 high. What does this mean?

Blood Clots too much: Beta-2 glycoprotein 1 antibody tests are used to help find the cause of unexplained blood clots (thrombotic episodes) or recurrent miscarriages. Also used to diagnose antiphospholipid syndrome (APS), or to detect the autoantibodies in someone with another autoimmune disorder. Sometimes may be ordered with cardiolipin antibody and lupus anticoagulant testing. IgG, IgM or IgA may be elevated. ...Read more

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What does this mean? My EBV AB VCA IGG is 239. my IGM is 36

What does this mean? My EBV AB VCA IGG is 239. my IGM is 36

Mono test: The EBV antibody viral capsid antigen IgG appears within 7 days after infection and last for life. The IGM antibody appears in 7 days, but lasts 3 months. Labs are various on tere actual levels, so you will need to talk to your provider about the levels in accordance with the labs norms. ...Read more

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On ceruplasmin test hep A AB Total reactive ref range U mean? Also Hep A AB (IGM) nonreactive ref range U mean? What am I testing positive for?

On ceruplasmin test hep A AB Total reactive ref range U mean? Also Hep A AB (IGM) nonreactive ref range U mean? What am I testing positive for?

Lab tests: You do not give a value for the ceruloplasm. If you have antibodies to Hepatitis A virus and the IgG is positive and the IgM negative it suggests that you were immunized for hepatitis A or had infection in the past. Why not discuss these values with the doctor who ordered them? ...Read more

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What does it mean to have a positive IgM p41 ab but IgM p39 ab. And IgM p23 ab. Are negative? What causes p41 to be present?

What does it mean to have a positive IgM p41 ab but IgM p39 ab. And IgM p23 ab. Are negative? What causes p41 to be present?

Unlikely lyme: P41 is not very specific for Lyme and 1.5 percent of general population may have it likely as protection against getting Lyme that is inherited rather than acquired. The other negative tests also confirm that u do not have it, but Lyme disease is a clinical diagnosis and all factors need to be considered. If you are still having symptoms, work with your doctor to get to the button of the problem ...Read more

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Core ab +be. Igm -ve. Surface antigen -ve. Surface ab +ve. E antigen -ve. E antibody +be. I was vaccinated for hepetitis b in 1996.Explain.

Core ab +be. Igm -ve. Surface antigen -ve. Surface ab +ve. E antigen -ve. E antibody +be. I was vaccinated for hepetitis b in 1996.Explain.

Sounds good: You'll do well to discuss with your personal health care provider, but it sounds to me like you recovered from an episode of hepatitis b, perhaps before you were immunized. ...Read more

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Age 49 healthy male. Oct 15 & Mar 16 EBV test comparisons. AB IGG >600 both AB IGM 52.4 74.4 EA IGG 23.4 29.2 NA IGG 51.3 40.5 Any advice, Tx?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your lab data indicates that you had EBV infection, like most adults have had. If you have no symptoms, there is nothing to be concerned about. ...Read more

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How long could the IgG in Lyme disease stay positive? Could it stay positive more than 5-10 years? I know the IgM ab convert to IgG just want an answer

Yes, positive 20+ yrs: Research suggests igg antibodies can persist at least 20 years after infection. While igm antibodies appear first, unlike other infections they often persist ; are a good indicator of persistent infection. One may have chronic lyme with or without persistence of igg antibodies. Chronic lyme is difficult to fully eradicate ; no current test proves that it is no longer present in your body! ...Read more

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Lyme IgG/IgM Ab result is <0.91."Reference interval:ISR 0.00-0.90, reference interval for neg is<0.91." Is test tesult neg with above 2 refer, interval

Lyme IgG/IgM Ab result is <0.91."Reference interval:ISR 0.00-0.90, reference interval for neg is<0.91." Is test tesult neg with above 2 refer, interval

Neg;might have Lyme: This is a negative result but does not mean you don't have Lyme. The type of test you had will be negative in at least half of those who have Lyme.
I advise you get a Western Blot from IgeneX but even that may be negative in 20% of those with Lyme.
See http://www. Betterhealthguy. Com/lyme/testing
for more info. ...Read more

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2 years ago I had lyme ab screen mildly elevevated but western blot all non reactive. Now im testing pos for igm 23 and igm 41. What does this mean?

2 years ago I had lyme ab screen mildly elevevated but western blot all non reactive. Now im testing pos for igm 23 and igm 41. What does this mean?

Interpret clinically: Lyme is known to be 'tricky'. The first set of tests I would ignore, since the Western blot was totally negative. In the second case, this could indicate an acute exposure since you've got 2 out of 3 IgM bands. You definitely need to talk to the doctor about these- since the lab work needs to be interpreted in the right clinical context. Sometimes lab tests come up as 'false positive'. See ID doc. ...Read more