Doctor insights on:
Antibody Vs Protein
Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?
?? Chronic Infection: M spike of polyclonal IgG (kappa & lambda) globulin mostly suggest chronic infectious or inflammatory process & rarely hematologic malignancies. You need a complete work up for ch. liver disease, hepatitis B/C, ch.bacterial, viral & fungal infection, HIV, autoimmune diseases & if negative then evaluate for hematological disorder. CHECK FOR Ch. INFECTION & HEPATITIS. Update me with your result. ...Read more
Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?
Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more
Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?
No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more
Released immune cell: It is a single band shown on a special test of aprotein plasma cells or white cells called lymphocytes. It sometimes causes symtpoms and is usually nothing to worry about. But i presume your dr. Did this..So speak to him/her about whether any other tests are needed..Or followup with a specialist. ...Read more
Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?
No: Can't interpret random blood test results without context. Talk to the doctor that ordered the tests. Most medical tests (x-rays, blood tests, etc., ) are better at telling us what you don't have rather than diagnosing what (if anything) you do have wrong with you. ...Read more
See a specialist: You don't tell me how you were found to have that high level. If you have no symptoms to go with that finding and other laboratory blood tests are normal, you probably have what is called monoclonal gammopathy. If you have symptoms or tests are affected, there are several possible diagnosis. For proper evaluation, see an immunologist or hematologist. ...Read more
Antibody to one site: Monoclonal antibodies (mab or moab) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a special parent cell. Monoclonal antibodies have monovalent affinity. That is, they bind to the same epitope/site. These can be used in treating cancer, autoimmune diseases, like rheumatoid arthritis, and in diagnostic tests, like western blot. ...Read more
Blood tests: They are two different separate blood tests, spep serum protein electrophoresis test is a screening test for plasma cell disorders like mgus, smoldering or full blown myeloma and quantitative igg is a blood test to quantify the amount of igg in blood. Usually more than 3 grams is significant in blood. ...Read moreSee 1 more doctor answer
Different substances: 80% of protein in milk is casein, 20% whey. They have different balances of amino acids, whey is absorbed more quickly and they have different effects. See http://www.bodybuilding.com/fun/satternorton.htm and http://www.bodybuilding.com/fun/casein_vs_whey_protein.htm and https://www.t-nation.com/supplements/whey-vs-casein-the-real-story for more details. ...Read moreSee 1 more doctor answer
Tested for anti cardiolipin IgM is negative(0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?
High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC
Anti cyclic citrullinated peptide antibody value 0.58.. Sensitivity of method 68% and specificity 92% ... What does it indicate?
Not Diagnostic of: These tests do not indicate a recent infection.IGM has to be above. 40 and IGG is positive which suggest you might have been infected in the past. Only tests to confirm acute infection are stool for H Pylori Antigen and/ or Urea Bresth Test.Or CLOE test during endoscopy . Discuss your case with your Doctor or Gastroenterologist ...Read more
Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more
Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.
False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read moreSee 1 more doctor answer
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
Clinical context : The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read moreSee 1 more doctor answer