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Doctor insights on: Antibody Vs Protein

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What is IgA kappa monoclonal protein?

What is IgA kappa monoclonal protein?

IgA paraprotein: An IgA kappa monoclonal protein represents a single clone of bone marrow cells that have reproduced in an aberrant fashion. If this is what is found on immunofixation then a hematologist should be consulted for further workup. ...Read more

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Protein (Definition)

Proteins are large molecules made up of a smaller class of molecules called amino acids. Proteins play an enormous role in the function of our bodies including enzymes, messengers, replicating dna, ...Read more


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Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?

Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?

?? Chronic Infection: M spike of polyclonal IgG (kappa & lambda) globulin mostly suggest chronic infectious or inflammatory process & rarely hematologic malignancies. You need a complete work up for ch. liver disease, hepatitis B/C, ch.bacterial, viral & fungal infection, HIV, autoimmune diseases & if negative then evaluate for hematological disorder. CHECK FOR Ch. INFECTION & HEPATITIS. Update me with your result. ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?

No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more

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What is an IgG lambda paraproteins?

Released immune cell: It is a single band shown on a special test of aprotein plasma cells or white cells called lymphocytes. It sometimes causes symtpoms and is usually nothing to worry about. But i presume your dr. Did this..So speak to him/her about whether any other tests are needed..Or followup with a specialist. ...Read more

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Whey protein or soy protein, what is better?

Whey protein or soy protein, what is better?

Depends: Use of soy protein might increase the chance for male to develop breasts or gynecomastia. Soy protein might help with to lessen the effects of menopause. I guess it depends on wether you are male or female. ...Read more

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Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?

Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?

No: Can't interpret random blood test results without context. Talk to the doctor that ordered the tests. Most medical tests (x-rays, blood tests, etc., ) are better at telling us what you don't have rather than diagnosing what (if anything) you do have wrong with you. ...Read more

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Gold standard whey protein isolate vs. Natural, which is better?

They= the same. ...: However u ingest ur protein is a matter of choice. They r both metabolized in the same way. Broken down in the digestive process ; put 2 use in the same way. ...Read more

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What does high IgG kappa monoclonal protein in blood mean?

What does high IgG kappa monoclonal protein in blood mean?

See a specialist: You don't tell me how you were found to have that high level. If you have no symptoms to go with that finding and other laboratory blood tests are normal, you probably have what is called monoclonal gammopathy. If you have symptoms or tests are affected, there are several possible diagnosis. For proper evaluation, see an immunologist or hematologist. ...Read more

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Whats a monoclonal antibody?

Whats a monoclonal antibody?

Antibody to one site: Monoclonal antibodies (mab or moab) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a special parent cell. Monoclonal antibodies have monovalent affinity. That is, they bind to the same epitope/site. These can be used in treating cancer, autoimmune diseases, like rheumatoid arthritis, and in diagnostic tests, like western blot. ...Read more

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Is a IgG quantitative test same as the serum protein electrophoresis test?

Is a IgG quantitative test same as the serum protein electrophoresis test?

Blood tests: They are two different separate blood tests, spep serum protein electrophoresis test is a screening test for plasma cell disorders like mgus, smoldering or full blown myeloma and quantitative igg is a blood test to quantify the amount of igg in blood. Usually more than 3 grams is significant in blood. ...Read more

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What is difference between casein protein and whey protein ?

What is difference between casein protein and whey protein ?

Different substances: 80% of protein in milk is casein, 20% whey. They have different balances of amino acids, whey is absorbed more quickly and they have different effects. See http://www.bodybuilding.com/fun/satternorton.htm and http://www.bodybuilding.com/fun/casein_vs_whey_protein.htm and https://www.t-nation.com/supplements/whey-vs-casein-the-real-story for more details. ...Read more

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Tested for anti cardiolipin IgM is negative(0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?

Tested for anti cardiolipin IgM is negative(0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?

Not sure: I am not sure I understand the question. I suspect you are being evaluated for a blood clotting disorder and you have an elevated anticardiolipin IgG. One test however does not make the diagnosis of anti-phospholipid syndrome. ...Read more

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Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

See details: The urine protein is within normal limits. How strongly positive is the igm cardiolipin. Only high levels of positivity have any clinical significance. Why were the tests ordered in the first place? ...Read more

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

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What is h.pylori blood antigen IGG and IGM meant ? IGG 17.95 and IGM 8.50

What is h.pylori blood antigen IGG and IGM meant ? IGG 17.95 and IGM 8.50

Not Diagnostic of: These tests do not indicate a recent infection.IGM has to be above. 40 and IGG is positive which suggest you might have been infected in the past. Only tests to confirm acute infection are stool for H Pylori Antigen and/ or Urea Bresth Test.Or CLOE test during endoscopy . Discuss your case with your Doctor or Gastroenterologist ...Read more

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Describe polyclonal and monoclonal antibody production?

Describe polyclonal and monoclonal antibody production?

Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context : The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more