Doctor insights on:
Antibody Screen Interpretation
Blood type: There is no such thing as "should" in clinical laboratory medicine. "It is what it is." If you forward-type as O-, we expect you have antibodies against red cells bearing A-antigen and against red cells bearing B-antigen. If you're sensitized to D (the main Rh factor), you have anti-D. However, all these are subject to other factors. Your physician &/or the lab pathologist can explain anomalies. ...Read more
I assume Rh?:
If you are rh negative and your partner is rh positive then you are trying to make antibodies against your baby. This is somewhat dose dependent so if you had a prior child, abortion, or miscarrige you are sensitized. Normally, after delivery, get medication to kill any rh positive cells in your body.
So the major risk is if you had a prior pregnancy and did not get the medication. ...Read more
Simple blood test: Antibody screening during pregnancy is essential to identify blood group and antigen incompatibilities that might be exist between a mother and her developing child. The screen involves determining the mothers blood group type: a, b, ab, o and rh status (pos and neg). About 10 percent of caucasian women (much lower in non-caucasian ethnicities) are rh negative entering pregnancy. ...Read more
27wkspreg Rh negPositive antibody screen today was neg a month ago had a prev ectopic and chem but had shot after What does this mean for this preg?
Rh factors: If your "shot" after your ectopic pregnancy was Rh immune globulin, which in Rh negative women is protective against problems from Rh disease in future pregnancies, the chance of a problem with this pregnancy is minimal. If you have had other pregnancies prior to your ectopic without Rh immune globulin given, continued testing is appropriate. ...Read more
Rhogam shots: "Rhogam" is immune globulin given to Rh negative women after a pregnancy. The Rhogam shot is in fact Rh positive antibodies, and if the "antibody screen" is done soon after a Rhogam, a "positive antibody screen" will result. This does not mean the individual is in fact "Rh positive", and is only the result of the Rhogam shot. ...Read more
3 hep c antibody screen tests done. First low positive, 2nd two neg. Thoughts? Could the two negatives be false negatives?
What would cause my Lyme antibody screen to be positive (1.20) and 4/10 igg bands reactive? What could this mean What additional testing should I get?
I am an L&D RN. I have an Rh+ pt who has turned up with a + antibody screen, 1 day before her scheduled C-section. Her screen was - in June. What??
Some ideas: She may have become sensitized to one of Dad's antigens other than Rh-D which is the usual problem one. The lab may be using more sensitive sera. The situation is fairly common. ...Read more
I just had an HIV 1/2 eia antibody screen w/ reflexes. Can you explain how this test works? Are there any better tests?
Viral Testing: To test for many infections we look for antibodies (your body's reaction to something new or foreign). In the case of HIV infection these antibodies can take three to six months to be positive on a test. This old fashioned test is a reliable and common screening tool. But, it is not the best test if one is possibly exposed. We now send HIV genetic tests which can be positive by day 21 post expos. ...Read more
Lyme antibody positive and western blot negative. Where can I find a complete list of other id's associated with a positive igm/igm antibody screen?!
Probably have Lyme!: I don't know where to find such a list as I am not sure the causes of a false positive are known, but, esp. If the western blot did not include the 34 ; 39 bands I would not rely upon it; please do the igenex western blot, which is much more sensitive ; specific for lyme. Even if that is negative 20-30% with lyme can have a negative WB test. Other tests may be indicated. See http://bit. Ly/1aaqjgc. ...Read more
Recently I took a HIV DNA PCR test and results were detected and reference range not detected, my HIV antibody screen test came back neg I am worried?
Blood cell antibody: If your blood type is a negative, that means your red blood cells lack the rh antigen (protein), if you are exposed to rh positive cells in a blood transfusion or in pregnancy, the rh antigen is foreign to you and your cells attack it with antibodies. The screen looks for these and other antibodies that could be harmful to a developing fetus. ...Read more
Definitely elevated: If your blood type is a negative, that means your red blood cells lack the rh antigen (protein), if you are exposed to rh positive cells in a blood transfusion or in pregnancy, the rh antigen is foreign to you and your cells attack it with antibodies. The screen looks for these and other antibodies that could be harmful to a developing fetus. A 1:16 level is high enough to cause problems. ...Read more
I understand that an antibody screen can be used to detect a certain type of pneumonia, among other conditions. Can it also be used to identify various infections in the way that blood cultures can?
Yes but: Usually an elevated IgM response to a particular organism indicates an acute infection. However doing IgM ab to a whole panel of bacteria is expensive and many of the tests are not available. The culture method is the default test but can be false-negative in many cases. In the future, I believe PCR analysis of bacterial DNA or a bacterial DNA microarray assays will likely be the way to go. ...Read more
I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9 and anachoice screen-positive...What lies ahead for me?
Diagnosis?: Connective tissue diseases can only be diagnosed if a person has symptoms and physical signs of a disease. Mctd cannot be diagnosed by blood test alone as a percent of the normal population has a positive rnp without any disease. It is not like checking your blood type (a positive, o negative, etc.). Ask your doctor how the diagnosis of mctd was made. ...Read more
ABO Type&Screen, does "negative" antibodies mean NO antibodies at all or no UNexpected antibodies for the reported blood type?
No unexpected ones: It means no antibodies against the red cells of the cross match. E.g., if you have type A blood, you would have anti-B antibodies as a matter of course. The potential donor blood is type A, but you also have no antibodies against any of the other antigens (outside of ABO system) which mY be found on red blood cells. ...Read more
I had the following test results- what do they mean? Rfactor -7, ANA choice screen - positive, rnp antibody- 2.0, DNA da antibody 5
Depends: In absence of clinical symptoms, probably nothing. Clinical evaluation should provide clarity. ...Read more
I miscarried twice. Doc advised me to do thrombophilia screen, anticardiopin antibody and lupus anticoagulant - what are they?
I was just diagnosd with mctd rnp antibody of 1.9 and anachoice screen-positive the only symptom is joint pain in my hand/wrist (i do have carpal tnl?
Positive Labs: Positive labs are meaningless unless you have symptoms. At this point, your doctor is aware of the positive results and will likely follow your symptoms. The positive simply means you are at a greater chance of developing symptoms though not everybody does. ...Read more
TSH, T3, (liothyronine) and T4 levels normal. Thyroglobulin antibody high (1.7 IU/mL). Small goiter with two <6mm nodules. 26y/o male. What to screen for?
US To Tell/More Info: I would want to know the true TSH (and T3/T4) as well prefer anti TPO Ab over Tg Ab. The worry of course is cancer. What you are describing is very low risk! You need an US (seems already done). 6 mm nodules are monitored unless there are suspicious finding on US, then bx suspicious nodules. If US OK, repeat in 6 mos. If TSH high nl with +Ab can also try course of thyroxine & nod may resolve. ...Read more
Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!
Lab numbers: These numbers don't show changes at joints and with most auto immune disorders, you may have periods of pain and increased lab numbers, usually related to stress in your life, and once treated medically or with stress reduction, pain/lab should improve. May want xray of one of involved joints just inflamed which can return to baseline. ...Read more
Could an immunoglobulin deficiency effectively mask an autoimmune disorder from auto-antibody screens such as AMA ANA etc. Or is it a separate thing?
No: When there is a total deficiency of the immunoglobulin, there can be no autoantibody formed from that particular class of immunoglobulin. Thus it is not a masking. However this does not rule out that other immune mechanisms may not be the cause for a certain illness. ...Read more
Is there anything else besides lupus and crest syndrome that could lead to high centromere anitbodies on a nuclear ab screen? Could it just be a fluke
5 to 7 days: The ability to detect the antibodies affects this answer. The early antibodies are those of the IgM class but there are 5 all together. The antibodies can be formed fast but until a certain level occurs they can not be detected. 5 to 7 days for the early IgM antibodies and longer for igg more permanent antibodies. ...Read more
Bind to site (s).: Antibodies (abs) are molecules made to bind to sites on infected cells, bacteria, viral particles, etc. To help the immune system fight disease. For example, monoclonal antibodies bind to the same epitope/site, while polyclonal abs bind to many sites. These can be used in treating cancer and hdnb, autoimmune diseases, like rheumatoid arthritis, and in diagnostic tests, like western blot. ...Read more