Doctor insights on:
Should my identical twin sister be tested for DNA because I have inflammatory markers and postive ANA antibody test?
It's her call: It sounds like a search for lupus. If you do turn out to have lupus, it's way below even-money that your identical twin will ever be affected, there's little to be gained from early diagnosis, if she develops symptoms she has the heads-up. The antibodies do appear several years before the illness if she is very curious. ...Read moreSee 1 more doctor answer
Not sure,: there could be multiple answers to this (it seems like NS1 could be a common abbreviation). I do know that a structural protein associated with viruses (that cause diseases such as Dengue fever and Yellow fever) is used for diagnosis. ie, if you have antibody to this NS1 protein, then you have been exposed to that pathogen ...Read more
Used for diagnosis: of mixed connective tissue disease (generally scleroderma with lupus overlap and muscle inflammation) for which it is fairly specific (accurate). The action of the antibody is not well characterized and probably less important than its use for diagnostic purpose (we know it binds to a protein for RNA building). In patients with anti-centromere Ab+ scleroderma, it portends kidney complications. ...Read more
5 to 7 days: The ability to detect the antibodies affects this answer. The early antibodies are those of the IgM class but there are 5 all together. The antibodies can be formed fast but until a certain level occurs they can not be detected. 5 to 7 days for the early IgM antibodies and longer for igg more permanent antibodies. ...Read more
A warrior increase: Think of an antibody as a soldier to help you beat the enemy (infection) if you have increasing antibodies you have more warriors. The problem here is if the warriors decide to fight against your own body rather than infection. You then have an auto-immune disease like rheumatoid arthritis. ...Read more
Bind to site(s).: Antibodies (abs) are molecules made to bind to sites on infected cells, bacteria, viral particles, etc. To help the immune system fight disease. For example, monoclonal antibodies bind to the same epitope/site, while polyclonal abs bind to many sites. These can be used in treating cancer and hdnb, autoimmune diseases, like rheumatoid arthritis, and in diagnostic tests, like western blot. ...Read more