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Doctor insights on: Antibody Interaction

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Does complement affect IgG and IgM reactions with antigens?

Does complement affect IgG and IgM reactions with antigens?

Complement: Complement is a serum protein that works with IgM and some igg subtypes to destroy foreign invaders. Persons with complement deficiency can have an increased frequency of infections. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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HBV test results: Hepatitis B Surface Antigen: Nonreactive; Hepatitis B Core Antibodies: Reactive; HBV PCR: Negative. Need any medication or vaccine?

HBV test results: Hepatitis B Surface Antigen: Nonreactive; Hepatitis B Core Antibodies: Reactive; HBV PCR: Negative.  Need any medication or vaccine?

Excellent question: and your story stumps many a doctor, often! :) a lot of the recommendations depend on - are you someone with risk factors for HBV? is this the first time that it has been checked? are your liver enzymes normal? are you about to undergo any procedures/ treatments that could put you at risk for HBV? If you have no sig risk factors, yes, I'd vaccinate you if there's potential for exposure. ...Read more

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Ebvab VCA IgM <36 (range 0-35.9), ebvearly antigenab IgG 37 (0-8.9), ebvab VCA IgG >600 (0-17.9), EBV nuclearantigenab IgG 409 (0-17.9) mono? No mono?

Ebvab VCA IgM <36 (range 0-35.9), ebvearly antigenab IgG 37 (0-8.9), ebvab VCA IgG >600 (0-17.9), EBV nuclearantigenab IgG 409 (0-17.9) mono? No mono?

You had mono...: Your mono-like symptoms likely prompted the testing- i hope you are starting to feel a little better. Testing for different antibodies (igm and igg) against ebv, requires careful interpretation. In early phases of infection, the igm level peaks first followed by a decline; levels of igg peak afterwards, and may remain elevated for quite a while. ...Read more

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My ELISA anti rubella IgG negative(0.13 ul/ml) and ELISA anti rubella IgM positive(>400). Is it safe to pregnancy. ?

My ELISA anti rubella IgG negative(0.13 ul/ml) and ELISA anti rubella IgM positive(>400). Is it safe to pregnancy. ?

No: Igm rubella indicates recent exposure and body response to it. It does not refer immunity. Hence baby at risk for congenital rubella. ...Read more

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Hiv RNA qualitative test negative; but absolute CD4 helper-879;% CD4 pos. Lymph-31.4;abs.Cd8 suppressor-1204;% cd8 pos lymph-43.0;cd4:cd8 ratio-0.73?

Hiv RNA qualitative test negative; but absolute CD4 helper-879;% CD4 pos. Lymph-31.4;abs.Cd8 suppressor-1204;% cd8 pos lymph-43.0;cd4:cd8 ratio-0.73?

I wouldn't worry: Cd4 normally runs around 500-1000. Cd8 usually runs 150-1000 or so, but these ranges are set so that several percent of healthies fall outside. I'm not worried; you can repeat the RNA if you mistrust the lab. In healthy folks, the values vary chaotically. I had burning mouth for weeks after coxsackie herpangina and a viral infection may have through your cells out of kilter briefly. ...Read more

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Is a core positive antibody for hepetitis b is dangerous. Igm antibody negetive. Surface antigen negetive with surface antibody positive. Explain?

Is a core positive antibody for hepetitis b is dangerous. Igm antibody negetive. Surface antigen negetive with surface antibody positive. Explain?

Past infection: The results you described are consistent with a past infection with hepatitis b from which you have recovered. You body made antibodies to the constituents of the virus. These results are not a cause for concern. ...Read more

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Is antithyroglobulin antibody test the same as thyroglobulin antibody test?

Is antithyroglobulin antibody test the same as thyroglobulin antibody test?

Yes: Both address presence of antibody to the rhyroglobulin molecule made by thyroid gland. See this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/003557.htm. ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Andrographis paniculata safety, contraindications, interactions -- liver, blood clotting/bruising, constipation/diarrhea?

Andrographis paniculata safety, contraindications, interactions -- liver, blood clotting/bruising, constipation/diarrhea?

Side effects: This herb can cause intestinal and liver irritation as wellas diarrhea and other minor side effects. Consult your doctor before use. ...Read more

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

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Hiv ab,1/2, eia with relx result repeatedly reactive. HIV 1/2ab differentiation w/refl hiv1 antibody negative hiv2 antibody negative. pos or neg hiv?

Hiv ab,1/2, eia with relx result repeatedly reactive. HIV 1/2ab differentiation w/refl hiv1 antibody negative hiv2 antibody negative. pos or neg hiv?

It depends: In a situation like this you have one positive test and one negative test. The lab should run a tie-breaker test (HIV RNA) to give you a real answer. Also, the first test may be an older test 2nd or 3rd generation) instead of the latest 4th generation) test. It also depends on if you have flu-Like symptoms. Seek help from a specialist in HIV who can help you understand. ...Read more

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Hsv type1 IgG antibdy=0.41, HSV type2 IgG antibdy= 0.41 is this means negative? Helicobactef pylori =3.91, is this transmitted disease too?

Hsv type1 IgG antibdy=0.41, HSV type2 IgG antibdy= 0.41 is this means negative? Helicobactef pylori =3.91, is this transmitted disease too?

Serologies: Am not familiar with the lab values that you are using. Each laboratory may put out differing results depending upon the test they use. Almost everybody (>93%) has hsv in their body. H. Pylori, if you have it, can be easily treated and eliminated. ...Read more

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05/05/2016 Siemens Advia Centaur hep C antibody result positive.08/10/2016 Abbott Architect (cmia) hep C antibody result negative.Who is telling truth?

05/05/2016 Siemens Advia Centaur hep C antibody result positive.08/10/2016 Abbott Architect (cmia) hep C antibody result negative.Who is telling truth?

It's not really: a question of truth telling. No test is perfect: the proteins and reactants used in each test will respond to an individual's blood/biologic material, potentially, in a different way. Falsely positive or falsely negative results are not very unusual. You need to decide on a confirmatory strategy with your doctor. Retesting is necessary and an expert can help you weigh the evidence to decide result ...Read more

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Hi please help, hepb surface antigen positive, hep b surface antigen confirmatory negative, antibody negative and anti core negative.What does it mean?

Hi please help, hepb surface antigen positive, hep b surface antigen confirmatory negative, antibody negative and anti core negative.What does it mean?

Hepatitis B testing: You should have it rechecked. Hbsag or surface antigen tests are the same, not like in HIV which has screening and confirmatory test. Normally, in the window period after an acute infection, all test for surface antigen or its antibodies are negative except for antibody to core antigen. Hbsag or surface antigen appears right after infection or exposure and disappears in recovery. ...Read more