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Doctor insights on: Anti Tissue Transglutaminase Iga

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My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

My serum test is negative for endomysial antibody  iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin  antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture. ...Read more

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


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Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

No: In and of itself , seborrheic dermatitis does not cause any significant immunologic disorders although certain diseases do have an association with seborrheic dermatitis-like rashes such as zinc deficiency syndromes and parkinsonism, for instance. ...Read more

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Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

TTG: I woul recommend having a ttg IgA antibody and possible duodenal bx , in doing so a diagnosis of celiac disease can be made. If if asymptomatic, there may be benefit from a gluten free diet especially if small bowel inflammation noted. ...Read more

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What is the blood test tissue transglutaminase antibody?

What is the blood test tissue transglutaminase antibody?

Coeliac Disease.: This is a test for the autoantibody to the transglutaminase protein. These are found in coeliac disease. This is a sign, that there is a reaction to transglutaminase protein and its binding with gliadin, a wheat protein, as well as cross reaction with the small intestine. Thus, patients cannot get nutrition from foods containing gliadin, and need a gluten-free diet.. ...Read more

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Iga test results "insufficient". No levels recorded. Gliadin igiga an "not indicated". Tis.Transglut.Ab IgA "not indicated". Means?

Iga test results "insufficient". No levels recorded. Gliadin igiga an "not indicated". Tis.Transglut.Ab IgA "not indicated". Means?

Ok: If you have undetectable iga, any test involving IgA would be meaningless and negative regardless of the disease condition. You will need alternate testing and even intestinal biopsy to document your illness if gluten intolerance is suspected. Make sure to check the other classes of immunoglobulin to make sure you don't have an immune defect. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more

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What do my celiac disease tissue transglutaminase iga/igg results mean?

What do my celiac disease tissue transglutaminase iga/igg results mean?

Anti-transglutaminas: Antibodies that bind to transglutaminase could indicate the presence of celiac disease. This is a sugggestive test only. Negative testing does not definitively rule-out celiac dz and positive testing does not confirm the diagnosis. An intestinal biopsy would be the most helpful test. ...Read more

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What specific immunoglobulins are found in bovine colostrum? Iga, igg, igm...Etc.?

Bovine Colostrum: Bovine colostrum from pasture-fed cows contains immunoglobulins specific to many human pathogens, including escherichia coli, cryptosporidium parvum, shigella flexneri, salmonella, staphylococcus, [28] and rotavirus (which causes diarrhea in infants). Likely igm, igg, and IgA although I am not specific about this. ...Read more

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Muscle Biopsy Results Meaning? rare chronic inflammatory cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

Muscle Biopsy Results Meaning? rare chronic inflammatory
cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

All lab test need ..: With data we need clinical context. That is why you are having trouble. There is not enough information to provide an interpretation. ...Read more

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Anti thryroglobulin anti level 14.9 ?anti microsomal ab level 77?

Anti thryroglobulin anti level 14.9 ?anti microsomal ab level 77?

Elevated: Hi. In the labs I know, those levels would be above normal, indicating an autoimmune process in the thyroid. They do not imply anything about thyroid function, and can be seen elevated in hyperthyroidism, hypothyroidism, and with normal thyroid function. If your thyroid function is abnormal, those antibodies would imply an autoimmune etiology. ...Read more

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Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

See details: The urine protein is within normal limits. How strongly positive is the igm cardiolipin. Only high levels of positivity have any clinical significance. Why were the tests ordered in the first place? ...Read more

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Can malabsorption from small bowel Crohn's decrease sensitivity of IBD blood panel? Wouldn't low serum globulin = fewer antibodies for test 2 detect?

Can malabsorption from small bowel Crohn's decrease sensitivity of IBD blood panel? Wouldn't low serum globulin = fewer antibodies for test 2 detect?

>100,000 proteins: Globulin = total proteins less albumen, the most abundant protein. While globulins includes antibodies, it also includes many other proteins. Within the 5 antibody subclasses (IgM, IgG, IgA, IgE & IgD), with >100,000 specific binding activities for just IgG, the whole point is the ratio of relative targeting specifics, competing physiologic controls & responses. Globulin can be ? & targeting also ? ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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Can mixed connective tissue disease be diagnosed with a positive ANA and positive rnp anitibodies?

NO.: You must have a compatible clinical picture first and the absence of another diffuse connective tissue disorder which could explain the symptoms and lab findings. A high titer ANA and anti-u1-rnp is a pretty good marker of mctd though. ...Read more

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What is the definition or description of: tissue transglutaminase iga?

What is the definition or description of: tissue transglutaminase iga?

Celiac disease : Since 1997, tissue transglutaminase has been recognized to be the autoantigen pathophysiologically recognized by the immune system that leads to celiac disease. Testing IgA antibodies to ttg is a diagnostic marker that for diagnosing celiac disease that is pretty reliable and relatively inexpensive. There can be false pos and false neg, though. ...Read more

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My TISSUE TRANSGLUTAMINASE IGA is <1.23 U/mL, range is <=3.99 U/mL and my IGA is 114 mg/dL range is 70 - 400 mg/dL, what does this indicate ?

My TISSUE TRANSGLUTAMINASE IGA is <1.23 U/mL, range is  <=3.99 U/mL and my IGA is 114 mg/dL range is 70 - 400 mg/dL, what does this indicate ?

Celiac unlikely: Why were these tests done? Do you have any symptoms? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it is unlikely that you have Celiac disease/gluten intolerance. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Tissue transglutaminase IgA resulted in 2.26. Igg resulted in .47. Does that necessarily mean I have celiac disease?

Tissue transglutaminase IgA resulted in 2.26. Igg resulted in .47. Does that necessarily mean I have celiac disease?

Looked normal: Iga ttg below 19 u is considered normal. Unless you had an IgA deficiency, i wonder why igg ttg was ordered? If you indeed had an IgA deficiency, then even the slightly positive igg titer would warrant hla genetic testing. If the figures provided were in units, then you do not have celiac disease. ...Read more

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What do my celiac disease tissue transglutaminase iga/igg results mean?

Anti-transglutaminas: Antibodies that bind to transglutaminase could indicate the presence of celiac disease. This is a sugggestive test only. Negative testing does not definitively rule-out celiac dz and positive testing does not confirm the diagnosis. An intestinal biopsy would be the most helpful test. ...Read more

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Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

No: In and of itself , seborrheic dermatitis does not cause any significant immunologic disorders although certain diseases do have an association with seborrheic dermatitis-like rashes such as zinc deficiency syndromes and parkinsonism, for instance. ...Read more

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My 13y/o daughter has type 1 diabetes. She recently had blood work and her tissue transglutaminase antibody IgA came back high at 39, why is this?

My 13y/o daughter has type 1 diabetes. She recently had blood work and her tissue transglutaminase antibody IgA came back high at 39, why is this?

Celiac sprue screen: People with type i diabetes are at extra risk for some of the other autoimmune diseases including gluten enteropathy. What her physician will do this this information remains to be seen -- your daughter's old enough to talk and participate in any decisions such as a possible trial of a gluten-free diet. ...Read more

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What do my celiac disease tissue transglutaminase test results mean?

Depends...: If the test was performed to identify whether you have celiac disease, an unequivocally elevated ttg value is diagnostic for celiac disease. If you are IgA deficient, and the only ttg assayed was iga, you may miss a diagnosis of celiac disease due to a falsely negative result. If you have celiac disease, ttg can be used to assess how compliant you may be with strict dietary gluten avoidance. ...Read more

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What is the blood test tissue transglutaminase antibody?

Coeliac Disease.: This is a test for the autoantibody to the transglutaminase protein. These are found in coeliac disease. This is a sign, that there is a reaction to transglutaminase protein and its binding with gliadin, a wheat protein, as well as cross reaction with the small intestine. Thus, patients cannot get nutrition from foods containing gliadin, and need a gluten-free diet.. ...Read more

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Are elevated tissue transglutaminase antibodies a possible reason for sneddons syndrome because of their effect on thrombin and the endothelia lining?

Bad fit: Glad you're interested in basic pathology. Not a bad conjecture. But if this were the case, sneddon's would run with gluten enteropathy. It doesn't. Under the microscope, sneddon's is a proliferative endarteritis with lymphocytes and macrophages, not what we see in antibody-antigen mediated vasculitis. ...Read more

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My 1year old, child has, normal anti transglutaminas IgA 9.4u/ml buy anti transglutaminase is, positive, 43.2u/ml what do you diagnose?

Antibodies to tissue: Antibodies to tissue transglutaminase are found in patients with several conditions, including coeliac disease, juvenile diabetes, inflammatory bowel disease, and various forms of arthritis. . Deposits of anti-ttg in the intestinal epithelium predict coeliac disease. The best thing you can do is to let the doctor evaluating your baby to work this out and discuss with you. ...Read more

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Ggt of 331 non drinker. Other lfts raised. Elevated iga?

This is serious: I trust you are not taking some other medication that is doing this to you. You'll be checked for autoimmune hepatitis, primary biliary cirrhosis, hepatitis b and c, sclerosing cholangitis (doubt), hemochromatosis, wilson's and antitrypsin deficiency. If all are negative, which is likely, suspect metabolic syndrome / fitness rx. I would not draw any additional conclusion from the elevated iga. ...Read more

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My age 25 years and my test result of anti transglutaminase-IgA = 3.00 U/ml and anti transglutaminase-IgG =5.07 U/ml what it means? ?

Means nothing: Without the clinical context. The doctor who ordered the test for yourself is the best to explain, those are tests done looking for a certain diagnosis on the basis of history and physical examination. At any rate, numbers aren't alarming ...Read more

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If I have an elevated transglutaminase iga, hypothyroidism, and a mother with celiac disease. Is the likelihood that I have celiac disease.?

If I have an elevated transglutaminase iga, hypothyroidism, and a mother with  celiac disease.  Is the likelihood that I have celiac disease.?

Yes, but ...: While your database is highly suggestive of a person at risk for celiac disease, the diagnosis still hinges on a diagnostic small bowel biopsy. Once the diagnosis is secure, a gluten-free diet should then result in a drop in tissue transglutaminase titer. ...Read more

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My daughter age 3y10m her weight is 8 kg and her test result of anti transglutaminase-IgA = 2.45 U/ml and anti transglutaminase-IgG =31.79 U/ml is she normal or not??

My daughter age 3y10m her weight is 8 kg and her test result of anti transglutaminase-IgA = 2.45 U/ml and anti transglutaminase-IgG  =31.79 U/ml             is she normal or not??

Should see your doc.: The tTG-IgA is in normal range, but IgG is elevated. This likely represents POSITIVE result SUGGESTING Celiac disease. However, a biopsy is needed to confirm the diagnosis. Because IgA is normal while IgG is high, this suggests possible IgA deficiency, which is more common in people with Celiac Disease. Either way, you should talk to your doc about the results as she may need further tests. ...Read more

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My doc sent me for the Celiac panel, Gliadin & Transglutaminase were normal but IGA serum was 424, doc said the norm is 90, what does this mean?

Nonspecific test: IgA is the bodies first line of defense for many infections at the mucosal surfaces. An elevated IgA is often associated with inflammation or infection. The test is very nonspecific alone and I'd advise you to continue to follow up with your physician as per their request for the work up of your symptoms. ...Read more

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My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture. ...Read more

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What does a low level of IgA mean?

What does a low level of IgA mean?

IgA deficiency is: the most common of all the "selective antibody deficiencies " occurring in 1:300-1:700 of the population. Levels vary greatly from person to person and in different age groups. Infants have the lowest range of normal and sometimes IgA is either extremely low or may be undetectable in the newborn period. Levels are typically checked if someone has recurring infections of the sinuses, ears or lung ...Read more

Dr. Mark Pack
5 doctors shared insights

Tissue Transglutaminase Iga (Definition)

Since 1997, tissue transglutaminase has been recognized to be the autoantigen pathophysiologically recognized by the immune system that leads to celiac disease. Testing IgA antibodies to ttg is a diagnostic marker that for diagnosing celiac disease that is pretty reliable and relatively inexpensive. There can be false pos ...Read more