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Doctor insights on: Anti Tissue Transglutaminase

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Does platelet rich plasma injections to ligaments cause scar tissue or new connective tissue?

Does platelet rich plasma injections to ligaments cause scar tissue or new connective tissue?

Both: Injecting platelet rich plasma is supposed to amplify the response of the repair cells by supplying growth factors to the area of injection. It's a good theory, but evidence of other than short term changes is lacking. ...Read more

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


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Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

No: In and of itself , seborrheic dermatitis does not cause any significant immunologic disorders although certain diseases do have an association with seborrheic dermatitis-like rashes such as zinc deficiency syndromes and parkinsonism, for instance. ...Read more

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Anti thryroglobulin anti level 14.9 ?anti microsomal ab level 77?

Anti thryroglobulin anti level 14.9 ?anti microsomal ab level 77?

Elevated: Hi. In the labs I know, those levels would be above normal, indicating an autoimmune process in the thyroid. They do not imply anything about thyroid function, and can be seen elevated in hyperthyroidism, hypothyroidism, and with normal thyroid function. If your thyroid function is abnormal, those antibodies would imply an autoimmune etiology. ...Read more

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What is the blood test tissue transglutaminase antibody?

What is the blood test tissue transglutaminase antibody?

Coeliac Disease.: This is a test for the autoantibody to the transglutaminase protein. These are found in coeliac disease. This is a sign, that there is a reaction to transglutaminase protein and its binding with gliadin, a wheat protein, as well as cross reaction with the small intestine. Thus, patients cannot get nutrition from foods containing gliadin, and need a gluten-free diet.. ...Read more

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Can mixed connective tissue disease be diagnosed with a positive ANA and positive rnp anitibodies?

Can mixed connective tissue disease be diagnosed with a positive ANA and positive rnp anitibodies?

NO.: You must have a compatible clinical picture first and the absence of another diffuse connective tissue disorder which could explain the symptoms and lab findings. A high titer ANA and anti-u1-rnp is a pretty good marker of mctd though. ...Read more

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My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

My serum test is negative for endomysial antibody  iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin  antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture. ...Read more

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Muscle Biopsy Results Meaning? rare chronic inflammatory cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

Muscle Biopsy Results Meaning? rare chronic inflammatory
cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

All lab test need ..: With data we need clinical context. That is why you are having trouble. There is not enough information to provide an interpretation. ...Read more

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Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more

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Is autoimmune hepatitis connective tissue disorder?

Is autoimmune hepatitis connective tissue disorder?

No: Autoimmune hepatitis is an inflammatory condition that effects the liver cells. Antibodies from a patient's own immune system attack the cells of the liver. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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What is fibrocollagenous tissue and adipose tissue?

Good question: Fibrocollagenous tissue is the connective tissue throughout our bodies that help maintain shape and function. Adipose tissue is fat. ...Read more

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Coexistence of hbsag and anti hbs?

Coexistence of hbsag and anti hbs?

It's possible.: When HBsAg and HBsAb are detected simultaneously, the first thing to do is to recheck the labs to be sure it is not in error. If it is confirmed, it is a rare instance of a mutation in the HBsAg region, and there is not good data about the response to conventional therapies. Be sure you were seeing an experienced hepatologist if this is present. Good luck. ...Read more

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What is a "connective tissue disease"? Had punch biopsy on rash, suggestive of early connective tissue disease. What is "connective tissue?"

What is a "connective tissue disease"? Had punch biopsy on rash, suggestive of early connective tissue disease. What is "connective tissue?"

Connective tissue: This is a constellation of disease affecting the supporting tissue throughout the body. It involves fat, cartilage,bone.there are different types with names such as Eleros Danlos , Marfans syndrome, Osteogensis imperfecta, they are all a result of gene dysfunction.ie are inheritable disorders. Most are fairly uncommon. The treatment varies depending on the specific areas involved ...Read more

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3.3cm soft tissue dens ant/sup mediastinum likely residual or reactive thymus tissue? Does ur need biopsy?

3.3cm soft tissue dens ant/sup mediastinum likely residual or reactive thymus tissue? Does ur need biopsy?

Could be either: The thymus tends to involute in adults and often is just a small vestige of an organ. It can however become active under certain circumstances. The most concerning issue would be a thymoma or tumor of the thymus gland. That is often seen in neurological conditions like myasthenia gravis. I would be curious to know how/why this was found. ...Read more

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Anti microsomal antibody is -191 and anti thyroglobulin antibody is-236.1 iu/ml what does it mean , suggest medicines?

Anti microsomal antibody is -191 and anti thyroglobulin antibody is-236.1 iu/ml what does it mean , suggest medicines?

Autoimmune: These antibody titers point to the presence of an autoimmune process which makes you at a higher risk of getting thyroid disease. Need to know what your thyroid function is and what kinds of symptoms you have before any suggestion on treatment can be made. Shouldn't you be talking to the doctor who ordered these tests? ...Read more

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What do my celiac disease tissue transglutaminase iga/igg results mean?

What do my celiac disease tissue transglutaminase iga/igg results mean?

Anti-transglutaminas: Antibodies that bind to transglutaminase could indicate the presence of celiac disease. This is a sugggestive test only. Negative testing does not definitively rule-out celiac dz and positive testing does not confirm the diagnosis. An intestinal biopsy would be the most helpful test. ...Read more

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Developed anca positive vasculitis with antihistone ab 1.4 and ESR 80. Can Losartan inhibit angiogenesis and make vasculitis or inflammation worse?

Developed anca positive vasculitis with antihistone ab 1.4 and ESR 80.  Can Losartan inhibit angiogenesis and make vasculitis or inflammation worse?

Rheumatology: Studies show that losartan can be associated with a drug induced ANCA positive Henoch-Schonlein purpura which is a form of vasculitis. Antinuclear antibody test looking to rule out not rule in drug induced systemic lupus erethematosus may have been performed. If you had another ANCA associated vasculitis and you are on losartan rheumatologist will instruct you if you should be taking it, call them ...Read more

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