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Doctor insights on: Anti Smooth Muscle Antibody

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Smooth Muscle (Definition)

Smooth muscle is an involuntary non-striated muscle. It is divided into two sub-groups; the single-unit (unitary) and multiunit smooth muscle. Smooth muscle is found within the walls of blood vessels. Smooth muscle is also found in lymphatic vessels, the urinary bladder, uterus, male and female reproductive tracts, gastrointestinal tract, respiratory tract, arrector pili of ...Read more


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What is smooth muscle antibody?

What is smooth muscle antibody?

Autoimmune hepatitis: This is an antibody marker often present in patients with the diagnosis of autoimmune hepatitis. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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What is the definition or description of: smooth muscle?

What is the definition or description of: smooth muscle?

See below: Smooth muscle is an involuntary non-striated muscle. It is divided into two sub-groups; the single-unit (unitary) and multiunit smooth muscle. Smooth muscle is found within the walls of blood vessels. Smooth muscle is also found in lymphatic vessels, the urinary bladder, uterus, male and female reproductive tracts, gastrointestinal tract, respiratory tract, arrector pili of skin, and other places. ...Read more

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What would happen if theres too much smooth muscle in bronchi?

What would happen if theres too much smooth muscle in bronchi?

Asthma: This is a common finding in asthma and probably is part of the reason that the airways squeeze shut too readily. ...Read more

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Does smooth muscle still work if we have a head injury?

Does smooth muscle still work if we have a head injury?

Yes: Smooth muscle is he rally not under voluntary control and should not be affected. ...Read more

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What conditions cause contraction of bronchiole smooth muscle?

What conditions cause contraction of bronchiole smooth muscle?

Asthma: Asthma is the prototypical disease whereby reversible bronchiolar smooth muscle constriction leads to tight airways and obstructive lung symptoms. Copd, or chronic obstructive pulmonary disease, also has a component of smooth muscle constriction. ...Read more

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What are bronchial smooth muscle contractions?

For breathing: Your breathing tubes, the bronchi, have smooth muscle around them to help you to breath. They can contract. ...Read more

Muscle (Definition)

It is a body tissue that has the ability to contract. It shortens and generates force. It relaxes and returns to its original length. Muscles move joints, stabilize the body, move air and food through the organs, act as valves for bladder, bowel and other organs. They control movement of the eyes. They help us express ourselves by changing the shape of our ...Read more


Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more