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Doctor insights on: Anti Smooth Muscle Antibody

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Smooth Muscle (Definition)

Smooth muscle is an involuntary non-striated muscle. It is divided into two sub-groups; the single-unit (unitary) and multiunit smooth muscle. Smooth muscle is found within the walls of blood vessels. Smooth muscle is also found in lymphatic vessels, the urinary bladder, uterus, male and female reproductive tracts, gastrointestinal tract, respiratory tract, arrector pili of ...Read more


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What is smooth muscle antibody?

What is smooth muscle antibody?

Autoimmune hepatitis: This is an antibody marker often present in patients with the diagnosis of autoimmune hepatitis. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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What is the definition or description of: smooth muscle?

What is the definition or description of: smooth muscle?

See below: Smooth muscle is an involuntary non-striated muscle. It is divided into two sub-groups; the single-unit (unitary) and multiunit smooth muscle. Smooth muscle is found within the walls of blood vessels. Smooth muscle is also found in lymphatic vessels, the urinary bladder, uterus, male and female reproductive tracts, gastrointestinal tract, respiratory tract, arrector pili of skin, and other places. ...Read more

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What would happen if theres too much smooth muscle in bronchi?

What would happen if theres too much smooth muscle in bronchi?

Asthma: This is a common finding in asthma and probably is part of the reason that the airways squeeze shut too readily. ...Read more

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Does smooth muscle still work if we have a head injury?

Does smooth muscle still work if we have a head injury?

Yes: Smooth muscle is he rally not under voluntary control and should not be affected. ...Read more

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What conditions cause contraction of bronchiole smooth muscle?

What conditions cause contraction of bronchiole smooth muscle?

Asthma: Asthma is the prototypical disease whereby reversible bronchiolar smooth muscle constriction leads to tight airways and obstructive lung symptoms. Copd, or chronic obstructive pulmonary disease, also has a component of smooth muscle constriction. ...Read more

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What are bronchial smooth muscle contractions?

For breathing: Your breathing tubes, the bronchi, have smooth muscle around them to help you to breath. They can contract. ...Read more

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Why is there a need for immunohistochemistry: smooth muscle actin after i got the diagnosis: cellular spindle cell lesion favor nodular fascitis?

Why is there a need for immunohistochemistry: smooth muscle actin after i got the diagnosis: cellular spindle cell lesion favor nodular fascitis?

To help diagnosis: Pathologists often use immunohistochemistry to help in arriving at a diagnosis. For softn tissue tumors immunohistochemistry can help better characterize the type of tumor...For example if is smooth muscle derived or a neural tumor etc. In terms of nodular fasciitis, it can morphologically appear similar to some smooth muscle tumors and some other fibroblastic tumors so ihc may be used. ...Read more

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1. What percentage of the time does cidp or gb present without significant associated muscle weakness. 2. How can cidp or gb effect smooth muscle. ?

1. What percentage of the time does cidp or gb present without significant associated muscle weakness.
2. How can cidp or gb effect smooth muscle. ?

See below: Commonly gbs starts with numbness and tingling that is bilateral and starting at the toes (variants of the disease differ in symptoms). Weakness has to be present for it to be gbs. Cidp is less predictable: weakness may not be present for a couple years. In these diseases peripheral nerves are stripped of myelin (the coating that allows for nerve transmission). Smooth muscle is not affected. ...Read more

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Is an orgasm an involuntary muscle contraction of the smooth muscle tissue?

Is an orgasm an involuntary muscle contraction of the smooth muscle tissue?

Sort of: Orgasm is a complex reaction that causes, among other things, certain smooth muscle fibers (vagina/uterus) to have rhythmic contractions. Not every smooth muscle contraction is due to an orgasm. ...Read more

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Is concerta less likely going to cause smooth muscle contraction than ritalin (methylphenidate)?

Is concerta less likely going to cause smooth muscle contraction than ritalin (methylphenidate)?

No: Concerta is methylphenidate, exactly the same molecule as ritalin. Concerta is formulated to be released into your bloodstream slowly so it lasts for 6 to 8 hours with a steady blood level, whereas Ritalin is absorbed rapidly and your blood level rises to a peak in about two hours and then declines, and is active for a total of about 4 hours. Same medication - same effects. ...Read more

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What is a smooth muscle ab blood test and a titer test for, and what does it mean if they're positive?

What is a smooth muscle ab blood test and a titer test for, and what does it mean if they're positive?

Ab vs smooth muscle.: This is a test for antibody to smooth muscle. These antibodies are usually associated with autoimmune hepatitis and can be directed against actin, troponin, and tropomyosin. ...Read more

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What causes smooth muscle contraction and possibly premature labor?

What causes smooth muscle contraction and possibly premature labor?

Three main reasons: 1.) Intrauterine infection 2) Incompetent cervix 3.)A premature drop in hormones causing labor initiation. Of course, there are many more reasons. ...Read more

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What is the best calcium blocker for intestine smooth muscle relaxation in achalasia?

What is the best calcium blocker for intestine  smooth muscle relaxation in achalasia?

Achalasia a name for: a behavior, not the reality of what is happening. Except for heart, no muscle cells in body contract without 0.001 sec nerve impulses to each muscle cell releasing neurotransmitter to trigger activation & contraction. Meds do not address, much less solve the real problems which are brain+neuromuscular. Since this is too complex for disease medicine, Docs focus only on aspects of end body behavior. ...Read more

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High res meno 1. Severe dysfunction of the smooth muscle esoph.2. No hiatal hernia, hypotensive les with normal relaxation.?Explain above cure?

High res meno  1. Severe dysfunction of the smooth muscle esoph.2. No hiatal hernia, hypotensive les with normal relaxation.?Explain above cure?

Complex: Could an entity known now as ineffective esophageal motility (iem). This is commonly associated with gerd. Dysmotility can also be due to diabetes and scleroderma. See a general surgeon or gastroenterologist with expertise in esophageal and foregut disorders for more info. ...Read more

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Is it safe to take oxycontin, 20mg ER tab twice a day, for my IBS with pain. For smooth muscle relaxant and pain with spasms. Could i go to 30mg.?

Is it safe to take oxycontin, 20mg ER tab twice a day, for my IBS with pain. For   smooth muscle relaxant and pain with  spasms. Could i go to 30mg.?

Ask your doc: All medication changes especially when dealing with a controlled substance should be discussed with your physician. Medication to medication interactions, medication side effects, and your specific medical conditions must all be taken into account in order to advise you properly. ...Read more

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Ct colonography report states diverticulosis particularly in the sigmoid with associated smooth muscle hypertrophy. What is smooth muscle hypertrophy?

Ct colonography report states diverticulosis particularly in the sigmoid with associated smooth muscle hypertrophy. What is smooth muscle hypertrophy?

Intestinal muscle is: The muscle in the intestinal wall is smooth muscle as distinguished from striated muscle such as the big muscles in your arms and legs. Often with diverticulosis, the muscle/wall of the bowel hypertrophies or thickens as part of the condition. ...Read more

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DoesPrazosin/other alpha blocks act on non-vascular smooth muscle e.g. the throat?If sudafed is alpha stim and contricts nasal,wouldnt it make sense?

DoesPrazosin/other alpha blocks act on non-vascular smooth muscle e.g. the throat?If sudafed is alpha stim and contricts nasal,wouldnt it make sense?

Good question: Alphablockers used to treat hypertension seem to be specific for their action on arteriolar musculature as far as I can tell clinically. Sudafed constricts smooth muscle in vessel walls, but can stimulate smooth muscle in the lower urinary tract and cause urinary retention at times. A pharmacologist would be best qualified to answer your question however. ...Read more

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Ertapenem antibiotic and muscle spasms, what to do?

Ertapenem antibiotic and muscle spasms, what to do?

Call the MD: Please call the doctor who prescribed the medication to you and discuss your side effect with them. You might need to be re-evaluated by them. ...Read more

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A antibiotic shot gave my left buttox a dent and it is smaller and less muscular does this mean the muscle is damaged and cannot be fixed w/ exercise ?

A antibiotic shot gave my left buttox a dent and it is smaller and less muscular does this mean the muscle is damaged and cannot be fixed w/ exercise ?

Likely fat tissue: deterioration. Was the area sore after the injection? You can smooth out the dent quite a bit by strengthening your gluteal muscles, causing them to enlarge as they strengthen--the Brazilian Butt Lift effect. The local fat degeneration may happen if the person who mixed up the shot added lidocaine with epinephrine rather than plain lidocaine! ...Read more

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My GI tract hasn't felt right after multiple antibiotic uses and Motrin (2 Uti's & a hurt neck muscle). What can I do to get it back to normal?

Stop antibiotics and: The more antibiotics you take the more you can alter your native biome. If you stay off of them for a while and take probiotics you will reconstitute your biome. Motrin is well known to cause gastric upset. If your stomach is upset avoid taking it. ...Read more

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Muscle pains in my left leg under the knee when i walk or even sit for the past one month. Dr gave antibiotic and pain killers. Only temporary relief.?

Muscle pains in my left leg under the knee when i walk or even sit for the past one month. Dr gave antibiotic and pain killers. Only temporary relief.?

See Ortho: That's probably your best bet to resolve this issue. Doesn't sound like an infectious process to me-more like a degenerative problem like arthritis or internal derangement of the knee(cartilage or meniscus injured). ...Read more

Muscle (Definition)

It is a body tissue that has the ability to contract. It shortens and generates force. It relaxes and returns to its original length. Muscles move joints, stabilize the body, move air and food through the organs, act as valves for bladder, bowel and other organs. They control movement of the eyes. They help us express ourselves by changing the shape of our ...Read more


Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more