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Doctor insights on: Anti Smith Antibodies

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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I know positive ANAs are found in healthy people, but are pos anti-RNPs also found in healthy people? What about dsDNA and anti-smith?

I know positive ANAs are found in healthy people, but are pos anti-RNPs also found in healthy people? What about dsDNA and anti-smith?

More specific: Low-titer RNP's may be found in healthy folks, but anti-Sm and anti-dsDNA at titers above the lab's cutoffs are fairly specific for lupus. The diagnosis and decision to treat are ultimately based on the whole clinical picture. ...Read more

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Is it possible to have positive Ana 1:80 and anti smith 13 then both negative month later? What happens? Lupus or not?

Is it possible to have positive Ana 1:80 and anti smith 13 then both negative month later? What happens? Lupus or not?

Yes, possible.: Esp they were both only minimally elevated. It can be falsely elevated with few situation one been most common is acute infection and had your blood work done around that same time. You likely don't have lupus but you can repeat again in 6 to 12 months. ...Read more

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I have had RA, ANA w/reflex, CRP (cardiac), TSH reflex to T4F, sed rate, anti-dsDNA, anti-Smith, all normal. Can I be confident nothing is wrong?

Can anybody?: It seems like you were having an evaluation for arthritis or fatigue (you don't state the symptoms you're concerned about). The studies you got all being normal should be fairly consoling but unfortunately even if we order every imaginable test we can still have one that comes back normal when in fact you have that disease- a false negative. Keep track of your symptoms and get back to your MD ...Read more

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I had a positive ANA test and positive smith antibodies. Will they find ra?

I had a positive ANA test and positive smith antibodies. Will they find ra?

Lupus: A high-titer ANA and a positive anti-sm (smith) usually means systemic lupus rather than rheumatoid arthritis. This is much more manageable today than in the past. No lab means much in isolation, and your physician ordered these labs because he/she suspected lupus. If the diagnosis is established, you'll probably want to join a community group for people with sle. Good luck. ...Read more

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My dr said my blood work shows smith antibody, but rheumatologist don't think it's lupus, then what is it?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. One autoantibody is not sufficient to make a diagnosis of lupus. It would be prudent to follow the advice from the rheumatologist. ...Read more

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Got my test results online.Says ANA speckled is at 1250. And other antibodies are found like ssa, ssb, rnp, smith, but are low levels. This mean SLE?

Not necesarily: While these tests point to a probability of a collagen vascular disease, this could be lupus, mixed connective tissue disease, etc. The doctor ordering these tests knows your history and physical examination findings and should be the one interpreting these tests. Should be a Rheumatologist. ...Read more

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Positive ANA, Positive Smith antibodies, protein in urine 100, creatine in urine 186. Should I be worried?

Lupus: Anti Smith antibodies are very specific for SLE. They can be positive in other autoimmune diseases including mixed connective tissue disease and scleroderma. A positive ANA especially one with homogenous staining is also associated with SLE but can be positive in other diseases. SLE can be associated with kidney disease with protein in the urine. 100 is normal. No kidney disease. ...Read more